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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
02/01/2014 |
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Data da última atualização: |
02/01/2014 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
DIAS-LOPES, C.; NESHICH, I. A. P.; NESHICH, G.; ORTEGA, J. M.; GRANIER, C.; CHÁVEZ-OLORTEGUI, C.; MOLINA, F.; FELICORI, L. |
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Afiliação: |
CAMILA DIAS-LOPES, UFMG; IZABELLA A. P. NESHICH, Unicamp; GORAN NESHICH, CNPTIA; JOSÉ MIGUEL ORTEGA, UFMG; CLAUDE GRANIER, SysDiag UMR 3145 CNRS/BioRad; CARLOS CHÁVEZ-OLORTEGUI, UFMG; FRANCK MOLINA, SysDiag UMR 3145 CNRS/BioRad; LIZA FELICORI, UFMG. |
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Título: |
Identification of new Sphingomyelinases D in pathogenic fungi and other pathogenic organisms. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
PLoS ONE, San Francisco, v. 8, n. 11, p. 1-12, 2013. |
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ISBN: |
10.1371/journal.pone.0079240 |
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Idioma: |
Inglês |
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Conteúdo: |
Sphingomyelinases D (SMases D) or dermonecrotic toxins are well characterized in Loxosceles spider venoms and have been described in some strains of pathogenic microorganisms, such as Corynebacterium sp. After spider bites, the SMase D molecules cause skin necrosis and occasional severe systemic manifestations, such as acute renal failure. In this paper, we identified new SMase D amino acid sequences from various organisms belonging to 24 distinct genera, of which, 19 are new. These SMases D share a conserved active site and a C-terminal motif. We suggest that the C-terminal tail is responsible for stabilizing the entire internal structure of the SMase D Tim barrel and that it can be considered an SMase D hallmark in combination with the amino acid residues from the active site. Most of these enzyme sequences were discovered from fungi and the SMase D activity was experimentally confirmed in the fungus Aspergillus flavus. Because most of these novel SMases D are from organisms that are endowed with pathogenic properties similar to those evoked by these enzymes alone, they might be associated with their pathogenic mechanisms. |
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Palavras-Chave: |
Bioinformática; Enzimas; Esfingomielinas. |
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Thesaurus Nal: |
Bioinformatics; Enzymes; Sphingomyelins. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/94633/1/Sphingomyelinases-D.pdf
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Marc: |
LEADER 01923naa a2200277 a 4500
001 1974829
005 2014-01-02
008 2013 bl uuuu u00u1 u #d
100 1 $aDIAS-LOPES, C.
245 $aIdentification of new Sphingomyelinases D in pathogenic fungi and other pathogenic organisms.$h[electronic resource]
260 $c2013
520 $aSphingomyelinases D (SMases D) or dermonecrotic toxins are well characterized in Loxosceles spider venoms and have been described in some strains of pathogenic microorganisms, such as Corynebacterium sp. After spider bites, the SMase D molecules cause skin necrosis and occasional severe systemic manifestations, such as acute renal failure. In this paper, we identified new SMase D amino acid sequences from various organisms belonging to 24 distinct genera, of which, 19 are new. These SMases D share a conserved active site and a C-terminal motif. We suggest that the C-terminal tail is responsible for stabilizing the entire internal structure of the SMase D Tim barrel and that it can be considered an SMase D hallmark in combination with the amino acid residues from the active site. Most of these enzyme sequences were discovered from fungi and the SMase D activity was experimentally confirmed in the fungus Aspergillus flavus. Because most of these novel SMases D are from organisms that are endowed with pathogenic properties similar to those evoked by these enzymes alone, they might be associated with their pathogenic mechanisms.
650 $aBioinformatics
650 $aEnzymes
650 $aSphingomyelins
653 $aBioinformática
653 $aEnzimas
653 $aEsfingomielinas
700 1 $aNESHICH, I. A. P.
700 1 $aNESHICH, G.
700 1 $aORTEGA, J. M.
700 1 $aGRANIER, C.
700 1 $aCHÁVEZ-OLORTEGUI, C.
700 1 $aMOLINA, F.
700 1 $aFELICORI, L.
773 $tPLoS ONE, San Francisco$gv. 8, n. 11, p. 1-12, 2013.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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Registro Completo
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
09/05/2022 |
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Data da última atualização: |
09/05/2022 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
KUNZ, A.; AMARAL, A. C. do; TÁPPARO, D. C.; MEZZARI, M. P.; STEINMETZ, R. L. R. |
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Afiliação: |
AIRTON KUNZ, CNPSA; ANDRÉ CESTONARO DO AMARAL; DEISI CRISTINA TÁPPARO; MELISSA PAOLA MEZZARI; RICARDO LUIS RADIS STEINMETZ, CNPSA. |
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Título: |
Influence of organic loading rate on archea community concentration in a cstr reactor treating swine manure. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
In: INTERNATIONAL SYMPOSIUM ON AGRICULTURAL AND AGROINDUSTRIAL WASTE MANAGEMENT, 7., 2021, On-line. Proceedings... Concórdia, SC: Sbera; Embrapa Suínos e Aves, 2022. |
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Páginas: |
p. 95. |
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Idioma: |
Inglês |
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Palavras-Chave: |
Archea; CSTR. |
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Thesagro: |
Biogás; Dejeto; Suinocultura. |
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Thesaurus NAL: |
Pig manure. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1142784/1/final9927.pdf
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Marc: |
LEADER 00780nam a2200229 a 4500
001 2142784
005 2022-05-09
008 2022 bl uuuu u00u1 u #d
100 1 $aKUNZ, A.
245 $aInfluence of organic loading rate on archea community concentration in a cstr reactor treating swine manure.$h[electronic resource]
260 $aIn: INTERNATIONAL SYMPOSIUM ON AGRICULTURAL AND AGROINDUSTRIAL WASTE MANAGEMENT, 7., 2021, On-line. Proceedings... Concórdia, SC: Sbera; Embrapa Suínos e Aves$c2022
300 $ap. 95.
650 $aPig manure
650 $aBiogás
650 $aDejeto
650 $aSuinocultura
653 $aArchea
653 $aCSTR
700 1 $aAMARAL, A. C. do
700 1 $aTÁPPARO, D. C.
700 1 $aMEZZARI, M. P.
700 1 $aSTEINMETZ, R. L. R.
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Embrapa Suínos e Aves (CNPSA) |
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