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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
22/12/2015 |
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Data da última atualização: |
21/01/2020 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
FULAZ, S. F.; CABRINI, F.; TASIC, L.; BORRO, L.; NESHICH, G. |
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Afiliação: |
STEPHANIE F. FULAZ; FLÁVIA CABRINI; LJUBICA TASIC; LUIZ BORRO; GORAN NESHICH, CNPTIA. |
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Título: |
Computational biology tools in design of an agrochemical against Xyllela fastidiosa. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
In: CONGRESSO DE INICIAÇÃO CIENTIFICA DA UNICAMP, 33., 2015, Campinas. [Proceedings...]. Campinas: Unicamp, 2015. |
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Descrição Física: |
1 pôster. |
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DOI: |
10.19146/pibic-2015-38174 |
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Idioma: |
Inglês |
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Conteúdo: |
Xylella fastidiosa is a Gram-negative, non-flagellated bacterium that causes CVC in citrus and Pierce?s disease in grapevines. The CVC affects 40% of the 200 million orange trees in São Paulo state. It colonizes the xylem vessels of the plants, blocking the water and nutrient flows. PilT protein is a part of the motility system and very important for Xyllela pathogenicity and our protein target for drug design. Computational biology tools were used to design the compound able to inhibit the formation of the PilT hexamer, leading to loss of Xyllela pathogenicity. This approach could be employed in the development of new inhibitors against different targets belonging to the same protein family of PilT. |
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Palavras-Chave: |
Bioinformática; Biology; Computational biology tools; Ferramentas de biologia computacional; PilT. |
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Thesagro: |
Xylella Fastidiosa. |
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Thesaurus Nal: |
Bioinformatics. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/136081/1/computational-Fulaz-pibic.pdf
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Marc: |
LEADER 01556nam a2200265 a 4500
001 2032282
005 2020-01-21
008 2015 bl uuuu u00u1 u #d
024 7 $a10.19146/pibic-2015-38174$2DOI
100 1 $aFULAZ, S. F.
245 $aComputational biology tools in design of an agrochemical against Xyllela fastidiosa.$h[electronic resource]
260 $aIn: CONGRESSO DE INICIAÇÃO CIENTIFICA DA UNICAMP, 33., 2015, Campinas. [Proceedings...]. Campinas: Unicamp$c2015
300 $c1 pôster.
520 $aXylella fastidiosa is a Gram-negative, non-flagellated bacterium that causes CVC in citrus and Pierce?s disease in grapevines. The CVC affects 40% of the 200 million orange trees in São Paulo state. It colonizes the xylem vessels of the plants, blocking the water and nutrient flows. PilT protein is a part of the motility system and very important for Xyllela pathogenicity and our protein target for drug design. Computational biology tools were used to design the compound able to inhibit the formation of the PilT hexamer, leading to loss of Xyllela pathogenicity. This approach could be employed in the development of new inhibitors against different targets belonging to the same protein family of PilT.
650 $aBioinformatics
650 $aXylella Fastidiosa
653 $aBioinformática
653 $aBiology
653 $aComputational biology tools
653 $aFerramentas de biologia computacional
653 $aPilT
700 1 $aCABRINI, F.
700 1 $aTASIC, L.
700 1 $aBORRO, L.
700 1 $aNESHICH, G.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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| Registros recuperados : 186 | |
| 41. |  | FULAZ, S. F.; CABRINI, F. M.; BORRO, L.; TASIC, L.; NESHICH, G. Computational Biology tools in design of an agrochemical against Xylella fastidiosa. In: CONGRESS OF THE INTERNATIONAL UNION FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 23.; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 44., 2015, Foz do Iguaçu. Biochemistry for a better world: abstracts book. [Foz do Iguaçu]: SBBq, 2015. p. 143. C.016.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
|    |
| 45. | | SCHULTZ, L. G.; VILLALTAROMERO, F.; BORRO, L.; JARDINE, J. G.; NESHICH, G.; TASIC, L. The host/guest interactions of the key protein for the bipolar disorder. In: ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 45., 2016, Natal. Livro de resumos... [Natal]: Sociedade Brasileira de Bioquímica e Biologia Molecular, 2016. Não paginado. Na publicação: José Jardine.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
|  |
| 46. | | PENA, I.; MANCINI, A. L.; MAZONI, I.; JARDINE, J. G.; NESHICH, G.; ORTEGA, J. M. Identification of philogenetic relationship between GDPD and SMaseD proteins based on active site amino acid physical chemical properties. In: INTERNATIONAL CONFERENCE OF BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 4., 2008, Salvador. Proceedings... Salvador: AB³C, 2008. Não paginado. X-Meeting 2008.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 47. | | MELO, R. C.; MAZONI, I.; NESHICH, G.; SANTORO, M. M.; MEIRA JÚNIOR, W. Contacts as the key elements for comparing two protein structures. In: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 14.; ANNUAL AB3C CONFERENCE, 2., 2006, Fortaleza. Conference Program... Fortaleza: ISCB, 2006. Não paginado. ISMB, X-MEETING 2006. Poster I-6.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 52. | | MELO, R. C.; MAZONI, I.; NESHICH, G.; SANTORO, M. M.; MEIRA JUNIOR, W. Protein structure topology comparison based on contact maps. In: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 14.; ANNUAL AB3C CONFERENCE, 2., 2006, Fortaleza. Conference Program... Fortaleza: ISCB, 2006. Não paginado. ISMB, X-MEETING 2006. Poster I-5.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 54. | | BORRO, L. C.; SALIM, J. A.; MAZONI, I.; YANO, I.; JARDINE, J. G.; NESHICH, G. Improving binding affinity prediction by using a rule-based model with physical-chemical and structural descriptors of the nano-environment for protein-ligand interactions. In: CONGRESS OF THE INTERNATIONAL UNION FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 23.; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 44., 2015, Foz do Iguaçu. Biochemistry for a better world: abstracts book. [Foz do Iguaçu]: SBBq, 2015. p. 153. C.047.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 57. | | MAZONI, I.; JARDINE, J. G.; BORRO, L. C.; ALVARENGA, D.; NESHICH, G. Electrostatic potential at the alpha carbon atoms along the alpha helices and beta strands. In: ANNUAL MEETING OF SBBQ, 37.; CONGRESS OF THE PAN-AMERICAN ASSOCIATION FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 11, 2008, Águas de Lindóia. Program and index... Águas de Lindóia, Program and index... Águas de Lindóia: SBBq, 2008. Não paginado. PABMB.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 58. | | SILVA, M. C. M. da; NESHICH, G.; CHRISPEELS, M.; HONIG, B.; SA, M. F. G. de. Molecular basis of the interactions between insect x-amylases and inhibitors. In: REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE BIOQUIMICA E BIOLOGIA MOLECULAR, 28., 1999, Caxambu, MG. Programa e resumos. Caxambu: Sociedade Brasileira de Bioquimica e Biologia Molecular, 1999. p.35E-63.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 59. | | MARCELLINO, L. H.; NESHICH, G.; GROSSI DE SA, M. F.; KREBBERS, E.; GANDER, E. S. Modified 2S albumins with improved tryptophan content are correctly expressed in transgenic tobacco plants. FEBS Letters, Amsterdam, v.385, n.3, p.154-158, 1996. p.154-158| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| Registros recuperados : 186 | |
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