Data/hora: 14/06/2024 19:06:16

Biblioteca(s): 	Embrapa Mandioca e Fruticultura.	
Data corrente: 	09/04/1996	
Data da última atualização: 	09/04/1996	
Autoria: 	MURAKAMI, A.; NAKAMURA, Y.; KOSHIMIZU, K.; OHIGASHI, H.	
Afiliação: 	Department of Science and Techonology, Faculty of Agriculture, Kyoto University, Kyoto 606-01. Japan.	
Título: 	Glyceroglycolipids from Citrus hystrix, a Traditional Herb in ThailandPotently Inhibit the Tumor-Promoting Activity of 12-0-Tetradecanoylphorbol 13-Acetate in Mouse Skin	
Ano de publicação: 	1995	
Fonte/Imprenta: 	J. Agric. \\Food Chem v. 43, 2779-2783, 1995.	
Idioma: 	Inglês	
Conteúdo: 	Two glyceroglycolipids were isolated from the leaves of Citrus hystrix (bitrter orange), a traditional herb in Thailand. They were identified as 1,2-di-0-a-linolenoyl-3-0-B-galactopyranosyl-sn-glycerol(DLGG,1) and a mixture of two compounds, 1-0-a-linolenoyl-2-0-palmitoyl-3-0-Bgalactopyranosyl-sn-glycerol (2a) and its couterpart (2b) (LPGG, 2). Both lipppds were potent inhibitors of tumor promoter-induced Epstein-Barr virus (EBV) activation. The IC50 values of 1 and 2 were strikingly lcancer preventive agents such as a-linolenic acid, B-carotene, or (-)-epigallocatechin gallate. In a two-stage carcinogenesis experiment on ICR mouse skin with dimethylbens[a]anthracene (DMBA) and 12-0-tetradecanoylphorbol 13-acetate (TPA), compound 1 exhibited anti-tumor-ppromoting activity even at a dose 10 times lower than that of a-linolenic acid. As some synthetic detergents or saponins were entirely inactive in the EBV activation inhibition test, detergency was suggested not to play a major role in the mode of inhibitory action in vivo. The inhibition of the arachidonic acid cascade may involved in anti-tumor promotion since 1 inhibited TPA-induced edema formation in the anti-inflammation test using ICR mouse ears.	
Palavras-Chave: 	Anti-tumor promoter; Cancer chemoprevention; Citrus ystrix; Controle; Doencas; EB virus; Glyceroglycolipid; Herb; Litoxidade; Prevencao; Raji cells; Spice.	
Thesagro: 	Vírus.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Mandioca e Fruticultura (CNPMF)	
Exemplares: 	CNPMF - (3662-1) - ADC - AP - -- - 630.51405 -  - 630.51405 - DIS