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Registro Completo |
Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
Data corrente: |
27/01/2021 |
Data da última atualização: |
15/06/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
FRAUCHES, N. S.; MONTENEGRO, J.; AMARAL, T.; ABREU, J. P.; LAIBER, G.; JORGE JUNIOR; BORGUINI, R. G.; SANTIAGO, M. C. P. de A.; PACHECO, S.; NAKAJIMA, V. M.; GODOY, R. L. de O.; TEODORO, A. J. |
Afiliação: |
Nayara Simas Frauches, UNIRIO; Júlia Montenegro, UNIRIO; Thuane Amaral, UNIRIO; Joel Pimentel Abreu, UNIRIO; Gabriela Laiber, UNIRIO; Jorge Junior, UFRJ; RENATA GALHARDO BORGUINI, CTAA; MANUELA CRISTINA P DE A SANTIAGO, CTAA; SIDNEY PACHECO, CTAA; Vania Mayumi Nakajima, UFF; RONOEL LUIZ DE OLIVEIRA GODOY, CTAA; Anderson Junger Teodoro, UNIRIO. |
Título: |
Antiproliferative Activity on Human Colon Adenocarcinoma Cells and In Vitro Antioxidant Effect of Anthocyanin-Rich Extracts from Peels of Species of the Myrtaceae Family. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Molecules, v. 26, n. 564 , 2021. p. 1-16. |
DOI: |
https://doi.org/10.3390/molecules26030564 |
Idioma: |
Inglês |
Conteúdo: |
There is a significant indication of the beneficial health effects of fruit rich diets. Fruitsof native plant species have noticeably different phytochemicals and bioactive effects. The aim ofthis work was to characterize and compare the constituents of jabuticaba (Myrciaria jaboticaba, MJ),jamun-berry (Syzygium cumini, SC), and malay-apple (Syzygium malaccense, SM) extracts and theirinfluence on antioxidant activityin vitroand antiproliferative effects on human colon adenocarci-noma cells. According to the results, dried peel powders (DP) have a high anthocyanin content,phenolic compounds, and antioxidant activity when compared to freeze dried extracts (FD).M.jaboticabadried peel powder extract had a higher total anthocyanin and phenolic compounds content(802.90±1.93 and 2152.92±43.95 mg/100 g, respectively). A reduction in cell viability of HT-29cells after treatment withM. jaboticabaextracts (DP-MJ and FD-MJ) was observed via MTT assay.Flow cytometry showed that the treatment with the anthocyanin-rich extracts from MJ, SC, and SMhad an inhibitory impact on cell development due to G2/M arrest and caused a rise in apoptotic cellsin relation to the control group. The findings of this study highlight the potential of peel powdersfromMyrtaceaefruits as an important source of natural antioxidants and a protective effect againstcolon adenocarcinoma |
Palavras-Chave: |
Colon cancer; Jamun-berry; Malay-apple; Myrtaceae fruits. |
Thesagro: |
Jabuticaba. |
Thesaurus Nal: |
Bioactive compounds. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/220691/1/molecules-26-00564.pdf
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Marc: |
LEADER 02414naa a2200337 a 4500 001 2129588 005 2021-06-15 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.3390/molecules26030564$2DOI 100 1 $aFRAUCHES, N. S. 245 $aAntiproliferative Activity on Human Colon Adenocarcinoma Cells and In Vitro Antioxidant Effect of Anthocyanin-Rich Extracts from Peels of Species of the Myrtaceae Family.$h[electronic resource] 260 $c2021 520 $aThere is a significant indication of the beneficial health effects of fruit rich diets. Fruitsof native plant species have noticeably different phytochemicals and bioactive effects. The aim ofthis work was to characterize and compare the constituents of jabuticaba (Myrciaria jaboticaba, MJ),jamun-berry (Syzygium cumini, SC), and malay-apple (Syzygium malaccense, SM) extracts and theirinfluence on antioxidant activityin vitroand antiproliferative effects on human colon adenocarci-noma cells. According to the results, dried peel powders (DP) have a high anthocyanin content,phenolic compounds, and antioxidant activity when compared to freeze dried extracts (FD).M.jaboticabadried peel powder extract had a higher total anthocyanin and phenolic compounds content(802.90±1.93 and 2152.92±43.95 mg/100 g, respectively). A reduction in cell viability of HT-29cells after treatment withM. jaboticabaextracts (DP-MJ and FD-MJ) was observed via MTT assay.Flow cytometry showed that the treatment with the anthocyanin-rich extracts from MJ, SC, and SMhad an inhibitory impact on cell development due to G2/M arrest and caused a rise in apoptotic cellsin relation to the control group. The findings of this study highlight the potential of peel powdersfromMyrtaceaefruits as an important source of natural antioxidants and a protective effect againstcolon adenocarcinoma 650 $aBioactive compounds 650 $aJabuticaba 653 $aColon cancer 653 $aJamun-berry 653 $aMalay-apple 653 $aMyrtaceae fruits 700 1 $aMONTENEGRO, J. 700 1 $aAMARAL, T. 700 1 $aABREU, J. P. 700 1 $aLAIBER, G. 700 1 $aJORGE JUNIOR 700 1 $aBORGUINI, R. G. 700 1 $aSANTIAGO, M. C. P. de A. 700 1 $aPACHECO, S. 700 1 $aNAKAJIMA, V. M. 700 1 $aGODOY, R. L. de O. 700 1 $aTEODORO, A. J. 773 $tMolecules$gv. 26, n. 564 , 2021. p. 1-16.
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Embrapa Agroindústria de Alimentos (CTAA) |
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Registro Completo
Biblioteca(s): |
Embrapa Instrumentação. |
Data corrente: |
22/12/1999 |
Data da última atualização: |
12/03/2010 |
Autoria: |
COLNAGO, L. A.; OPELLA, S. J. |
Afiliação: |
EMBRAPA-CNPDIA; University of Pennsylvania. |
Título: |
Structure and dynamics of filamentous bacteriophages by solid state NMR. |
Ano de publicação: |
1993 |
Fonte/Imprenta: |
In: REUNIAO ANUAL DE FISICA DA MATERIA CONDENSADA, 22., maio 1993, Caxambu, MG. Programa e resumos... Sao Paulo: Sociedade Brasileira de Bioquimica e Biologia Molecular, 1993. |
Páginas: |
p.9. |
Idioma: |
Inglês |
Conteúdo: |
High resolution multinuclear and multidimensional solution NMR is an alternative to X-ray diffraction to solve the structure of proteins up to 30KDa. For large structures, solid state NMR has been used in several cases. The structural information obtained from solid state NMR spectroscopy is due to the angular dependence of the dipolar and quadrupolar interactions and chemical shift anisotropy. Solid state NMR was used to solve the strucuture and dynamics of filamentous bacteriophages class 1(M13, fd and f1) and class 2(pF1). The viruses are very usefull in molecular biology, as vectors. A new application of these bacteriophages resides in a fusion of peptides or proteins to theirs coat proteins, to create epitope libraries, vaccines, etc. We have been using N15, multidimensional solid state NMR to solve the structure of these fused peptides in the coat protein of gene VIII. Preliminary results show that only part of the fused peptides are structured in the virus. |
Palavras-Chave: |
Bacteriophage; Filamentous; NMR; Solid state; Structure. |
Thesaurus NAL: |
dynamics. |
Categoria do assunto: |
-- |
Marc: |
LEADER 01658naa a2200217 a 4500 001 1026764 005 2010-03-12 008 1993 bl --- 0-- u #d 100 1 $aCOLNAGO, L. A. 245 $aStructure and dynamics of filamentous bacteriophages by solid state NMR. 260 $c1993 300 $ap.9. 520 $aHigh resolution multinuclear and multidimensional solution NMR is an alternative to X-ray diffraction to solve the structure of proteins up to 30KDa. For large structures, solid state NMR has been used in several cases. The structural information obtained from solid state NMR spectroscopy is due to the angular dependence of the dipolar and quadrupolar interactions and chemical shift anisotropy. Solid state NMR was used to solve the strucuture and dynamics of filamentous bacteriophages class 1(M13, fd and f1) and class 2(pF1). The viruses are very usefull in molecular biology, as vectors. A new application of these bacteriophages resides in a fusion of peptides or proteins to theirs coat proteins, to create epitope libraries, vaccines, etc. We have been using N15, multidimensional solid state NMR to solve the structure of these fused peptides in the coat protein of gene VIII. Preliminary results show that only part of the fused peptides are structured in the virus. 650 $adynamics 653 $aBacteriophage 653 $aFilamentous 653 $aNMR 653 $aSolid state 653 $aStructure 700 1 $aOPELLA, S. J. 773 $tIn: REUNIAO ANUAL DE FISICA DA MATERIA CONDENSADA, 22., maio 1993, Caxambu, MG. Programa e resumos... Sao Paulo: Sociedade Brasileira de Bioquimica e Biologia Molecular, 1993.
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