Data/hora: 01/06/2024 22:11:06

Biblioteca(s): | Ebooks.
Data corrente: | 01/02/2013
Data da última atualização: | 01/02/2013
Autoria: | MÜLLER, M.
Afiliação: | Markus Müller.
Título: | Clinical Pharmacology: Current Topics and Case Studies.
Ano de publicação: | 2010
Fonte/Imprenta: | Springer eBooks.
Páginas: | XXIV, 430 p.
Descrição Física: | digital.
ISBN: | 9783709101445
DOI: | 10.1007/978-3-7091-0144-5
Idioma: | Inglês
Conteúdo: | Section 1: Introduction -- Chapter 1: The discipline of Clinical Pharmacology -- Chapter 2: Current issue in drug development -- Chapter 3: Current issue in drug regulation -- Chapter 4: Current issue in drug reimbursement -- Section 2: Clinical Trials -- Chapter 5: Ethics in clinical research -- Chapter 6: Good Clinical Practice (GCP) and scientific misconduct -- Chapter 7: Phase-I studies and first-in-human trials -- Chapter 8: Clinical trials - interventional studies -- Chapter 9: Observational studies -- Chapter 10: Pharmacokinetics I: PK-PD approaches - antibiotic drug development -- Chapter 11: Pharmacokinetics II: 14C-labelled microdosing in assessing drug pharmacokinetics at Phase-0 -- Chapter 12: Epidemiology and bio statistics -- Chapter 13: Placebo effects and placebo control in clinical trials -- Section 3: Tools in Clincal Pharmacology -- Chapter 14: Tools in clinical pharmacology - imaging techniques -- Chapter 15: Current concepts of pharmacogenetics, pharmacogenomics, and the "druggable" genome -- Chapter 16: Biomarkers -- Chapter 17: Molecular tools in drug research - translational medicine -- Section 4: Topics in Clinical Pharmacology -- Chapter 18: Pharmaceutical drug safety -- Chapter 19: Drug interactions -- Chapter 20: "Non-chemical" drugs: biological, protein therapeutics, vaccines and antisense therapeutics -- Chapter 21: Development of Advanced Therapy Medicinal Products - a case for early scientific advice -- Chapter 22: Individualized medicine -- Chapter 23: Generics, biosimilars, enantiomers and me-toos -- Chapter 24: Special situation, market fragmentation I: orphan drugs for rare diseases -- Chapter 25: Special situations, market fragmentation II: sex differences -- Chapter 26: Special situations III: Medicines for Children.<P> Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP. <P>
Palavras-Chave: | Biomedicine; Pharmacology/Toxicology; Pharmacy.
Thesaurus Nal: | medicine; toxicology.
Categoria do assunto: | --
URL: | http://dx.doi.org/10.1007/978-3-7091-0144-5
Registro original: | Ebooks (Ebooks)