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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Oriental. Para informações adicionais entre em contato com cpatu.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
08/09/2017 |
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Data da última atualização: |
20/05/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
DUARTE JUNIOR, A. P.; TAVARES, E. J. M.; ALVES, T. V. G.; MOURA, M. R. de; COSTA, C. E. F. da; SILVA JÚNIOR, J. O. C.; COSTA, R. M. R. |
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Afiliação: |
Anivaldo Pereira Duarte Junior, UFPA; ERALDO JOSE MADUREIRA TAVARES, CPATU; Taís Vanessa Gabbay Alves, UFPA; Márcia Regina de Moura, UNESP; Carlos Emmerson Ferreira da Costa, UFPA; José Otávio Carréra Silva Júnior, UFPA; Roseane Maria Ribeiro Costa, UFPA. |
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Título: |
Chitosan nanoparticles as a modified diclofenac drug release system. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of Nanoparticle Research, v. 19, n. 8, article 274, 2017. |
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DOI: |
10.1007/s11051-017-3968-6 |
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Idioma: |
Inglês |
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Conteúdo: |
This study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% ( w/ v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50?100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% ( w/ v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% ( w/ v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and obeyed Korsmeyer-Peppas model, which was characterized mainly by Fickian diffusion transport. MenosThis study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% ( w/ v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50?100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% ( w/ v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% ( w/ v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and o... Mostrar Tudo |
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Palavras-Chave: |
Biopolímero; Nanopartícula; Nanotecnologia; Quitosana. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02347naa a2200253 a 4500
001 2075279
005 2022-05-20
008 2017 bl uuuu u00u1 u #d
024 7 $a10.1007/s11051-017-3968-6$2DOI
100 1 $aDUARTE JUNIOR, A. P.
245 $aChitosan nanoparticles as a modified diclofenac drug release system.$h[electronic resource]
260 $c2017
520 $aThis study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% ( w/ v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50?100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% ( w/ v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% ( w/ v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and obeyed Korsmeyer-Peppas model, which was characterized mainly by Fickian diffusion transport.
653 $aBiopolímero
653 $aNanopartícula
653 $aNanotecnologia
653 $aQuitosana
700 1 $aTAVARES, E. J. M.
700 1 $aALVES, T. V. G.
700 1 $aMOURA, M. R. de
700 1 $aCOSTA, C. E. F. da
700 1 $aSILVA JÚNIOR, J. O. C.
700 1 $aCOSTA, R. M. R.
773 $tJournal of Nanoparticle Research$gv. 19, n. 8, article 274, 2017.
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Embrapa Amazônia Oriental (CPATU) |
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| 8. |  | VIDAL, C. B. M.; DIAMANTINO, M. S. A. S.; HOHENFELD, C. S.; SANTOS, D. A.; OLIVEIRA, S. A. S. de. Seleção de genótipos de mandioca quanto à resistência à podridão radicular em ambiente controlado. In: JORNADA CIENTÍFICA EMBRAPA MANDIOCA E FRUTICULTURA, 15., 2021. Mulheres na ciência desafios, oportunidades e conquistas. Cruz das Almas, BA: Embrapa Mandioca e Fruticultura, 2021. PDF. 63.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| 11. | | MORAIS, D. V. de; CARVALHO, M. A. P. C. de; ARAÚJO, L. S.; DIAMANTINO, M. S. A. S. Desenvolvimento pós seminal dos genótipos de mamoneira IAC 2028 e BRS NORDESTINA sob estresse salino. In: CONGRESSO BRASILEIRO DE MAMONA, 5.; SIMPÓSIO INTERNACIONAL DE OLEAGINOSAS ENERGÉTICAS, 2.; FÓRUM CAPIXABA DE PINHÃO-MANSO, 1., 2012, Guarapari. Desafios e Oportunidades: anais. Campina Grande: Embrapa Algodão, 2012. p. 146| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Algodão. |
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| 12. | | MORAIS, D. V. de; CARVALHO, M. A. P. C. de; ARAUJO, L. S.; DIAMANTINO, M. S. A. S. Efeito do KCL no desenvolvimento inicial de cultivares de mamoneira. In: CONGRESSO BRASILEIRO DE MAMONA, 5.; SIMPÓSIO INTERNACIONAL DE OLEAGINOSAS ENERGÉTICAS, 2.; FÓRUM CAPIXABA DE PINHÃO-MANSO, 1., 2012, Guarapari. Desafios e Oportunidades: anais. Campina Grande: Embrapa Algodão, 2012. p. 156| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Algodão. |
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| 14. | | MORAIS, D. V. de; CARVALHO, M. A. P. C. de; ARAÚJO, L. S.; DIAMANTINO, M. S. A. S. Efeito da salinidade sob a germinação da cultivar de mamoneira IAC 226. In: CONGRESSO BRASILEIRO DE MAMONA, 5.; SIMPÓSIO INTERNACIONAL DE OLEAGINOSAS ENERGÉTICAS, 2.; FÓRUM CAPIXABA DE PINHÃO-MANSO, 1., 2012, Guarapari. Desafios e Oportunidades: anais. Campina Grande: Embrapa Algodão, 2012. p. 125| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Algodão. |
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| 18. | | NASCIMENTO, D. S.; OLIVEIRA, L. B. de; BARBOSA, A. C. O.; DIAMANTINO, M. S. A. S.; FERREIRA, C. F.; OLIVEIRA, S. A. S. de. Avaliação de marcadores RAPD para estudo de diversidade de bactérias associadas ao sintoma de requeima da mandioca In: JORNADA CIENTÍFICA EMBRAPA MANDIOCA E FRUTICULTURA, 17., 2017 Ciência e Empreendedorismo : resumos. Cruz das Almas, BA: Embrapa Mandioca e Fruticultura, 2017. 137p. 1p. Biotecnologia| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| Registros recuperados : 37 | |
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