Data/hora: 02/06/2024 00:06:51

Biblioteca(s): | Embrapa Caprinos e Ovinos.
Data corrente: | 12/11/2002
Data da última atualização: | 12/11/2002
Autoria: | JÓZWIK, M.; TENG, C.; MESCHIA, G.; BATTAGLIA, F. C.
Título: | Contribution of branched-chain amino acids to uteroplacental ammonia production in sheep.
Ano de publicação: | 1999
Fonte/Imprenta: | Biology of Reproduction, v. 61, n. 3, p. 792-796, 1999.
Idioma: | Inglês
Conteúdo: | The uteroplacental tissues are a principal site of ammonia (production for lhe conceptus. The goal of this study was to examine the effect of the composition of maternal amino acid (AA) infusate on uteroplacental ammonia production. Seven pregnant ewes (126 +- 1.4 days gestation) were infused through the maternal femoral vein (duration 3.5 h, rate 240 ml per hour) with  three solutions of AAs. The first infusate was comparable to commercial parenteral nutrition preparations, the second infusate contained the same solution without branched-chain AAs (BCAAs), and the third infusate contained only BCAAs. Blood samples were simultaneously collected from lhe maternal artery, uterine vein, fetal artery, and umbilical vein to determine plasma 1 AA concentrations and whole blood ammonia concentrations, before (control) and 2 h after (experimental) the start of infusion. Uterine and umbilical blood flows were measured using the ethanol steady-state diffusion method. Results showed that fetal arterial and venous ammonia concentrations increased significantly after infusions with all AAs or only BCAAs, but not without BCAAs. Uteroplacental ammonia production increased in response to each of the three infusates. However, this increase was much greater when lhe BCAAs were present in infusates. We conclude that there is a significant contribution of BCAAs to the uteroplacental ammonia production. Maternal AA infusions containing BCAAs can result in increased fetal blood ammonia concentrations.
Thesagro: | Aminoácido; Amônia; Ovino; Reprodução Animal.
Categoria do assunto: | --
Registro original: | Embrapa Caprinos e Ovinos (CNPC)
Exemplares: | CNPC - (15115-1) - ADC - AP - -- -  -  - v. 61, n.3 - DIS