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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agricultura Digital. Para informações adicionais entre em contato com cnptia.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
10/02/2014 |
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Data da última atualização: |
08/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MENDES, T. A. O.; LOBO, F. P.; RODRIGUES, T. S.; RODRIGUES-LUIZ, G. F.; ROCHA, W. D. da; FUJIWARA, R. T.; TEIXEIRA, S. M. R.; BARTHOLOMEU, D. C. |
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Afiliação: |
UFMG; FRANCISCO PEREIRA LOBO, CNPTIA; Centro Federal de Educação Tecnológica de Minas Gerais; UFMG; UFPR; UFMG; UFMG; UFMG. |
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Título: |
Repeat-enriched proteins are related to host cell invasion and immune evasion in parasitic protozoa. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Molecular Biology and Evolution, Chicago, v. 30, n. 4, p. 951-963, 2013. |
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DOI: |
10.1093/molbev/mst001 |
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Idioma: |
Inglês |
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Conteúdo: |
Proteins containing repetitive amino acid domains are widespread in all life forms. In parasitic organisms, proteins containing repeats play important roles such as cell adhesion and invasion and immune evasion. Therefore, extracellular and intracellular parasites are expected to be under different selective pressures regarding the repetitive content in their genomes. Here, we investigated whether there is a bias in the repetitive content found in the predicted proteomes of 6 exclusively extracellular and 17 obligate intracellular protozoan parasites, as well as 4 free-living protists. We also attempted to correlate the results with the distinct ecological niches they occupy and with distinct protein functions. We found that intracellular parasites have higher repetitive content in their proteomes than do extracellular parasites and free-living protists. In intracellular parasites, these repetitive proteins are located mainly at the parasite surface or are secreted and are enriched in amino acids known to be part of N- and O-glycosylation sites. Furthermore, in intracellular parasites, the developmental stages that are able to invade host cells express a higher proportion of proteins with perfect repeats relative to other life cycle stages, and these proteins have molecular functions associated with cell invasion. In contrast, in extracellular parasites, degenerate repetitive motifs are enriched in proteins that are likely to play roles in evading host immune response. Altogether, our results support the hypothesis that both the ability to invade host cells and to escape the host immune response may have shaped the expansion and maintenance of perfect and degenerate repeats in the genomes of intra- and extracellular parasites. MenosProteins containing repetitive amino acid domains are widespread in all life forms. In parasitic organisms, proteins containing repeats play important roles such as cell adhesion and invasion and immune evasion. Therefore, extracellular and intracellular parasites are expected to be under different selective pressures regarding the repetitive content in their genomes. Here, we investigated whether there is a bias in the repetitive content found in the predicted proteomes of 6 exclusively extracellular and 17 obligate intracellular protozoan parasites, as well as 4 free-living protists. We also attempted to correlate the results with the distinct ecological niches they occupy and with distinct protein functions. We found that intracellular parasites have higher repetitive content in their proteomes than do extracellular parasites and free-living protists. In intracellular parasites, these repetitive proteins are located mainly at the parasite surface or are secreted and are enriched in amino acids known to be part of N- and O-glycosylation sites. Furthermore, in intracellular parasites, the developmental stages that are able to invade host cells express a higher proportion of proteins with perfect repeats relative to other life cycle stages, and these proteins have molecular functions associated with cell invasion. In contrast, in extracellular parasites, degenerate repetitive motifs are enriched in proteins that are likely to play roles in evading host immune response. Altog... Mostrar Tudo |
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Palavras-Chave: |
Evasão imune; Evolução genômica; Invasão celular; Parasitas; Proteínas. |
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Thesaurus Nal: |
Cell invasion; Evolution; Immune evasion; Parasites; Proteins; Protozoa. |
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Categoria do assunto: |
S Ciências Biológicas |
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Marc: |
LEADER 02770naa a2200349 a 4500
001 1979314
005 2020-01-08
008 2013 bl uuuu u00u1 u #d
024 7 $a10.1093/molbev/mst001$2DOI
100 1 $aMENDES, T. A. O.
245 $aRepeat-enriched proteins are related to host cell invasion and immune evasion in parasitic protozoa.$h[electronic resource]
260 $c2013
520 $aProteins containing repetitive amino acid domains are widespread in all life forms. In parasitic organisms, proteins containing repeats play important roles such as cell adhesion and invasion and immune evasion. Therefore, extracellular and intracellular parasites are expected to be under different selective pressures regarding the repetitive content in their genomes. Here, we investigated whether there is a bias in the repetitive content found in the predicted proteomes of 6 exclusively extracellular and 17 obligate intracellular protozoan parasites, as well as 4 free-living protists. We also attempted to correlate the results with the distinct ecological niches they occupy and with distinct protein functions. We found that intracellular parasites have higher repetitive content in their proteomes than do extracellular parasites and free-living protists. In intracellular parasites, these repetitive proteins are located mainly at the parasite surface or are secreted and are enriched in amino acids known to be part of N- and O-glycosylation sites. Furthermore, in intracellular parasites, the developmental stages that are able to invade host cells express a higher proportion of proteins with perfect repeats relative to other life cycle stages, and these proteins have molecular functions associated with cell invasion. In contrast, in extracellular parasites, degenerate repetitive motifs are enriched in proteins that are likely to play roles in evading host immune response. Altogether, our results support the hypothesis that both the ability to invade host cells and to escape the host immune response may have shaped the expansion and maintenance of perfect and degenerate repeats in the genomes of intra- and extracellular parasites.
650 $aCell invasion
650 $aEvolution
650 $aImmune evasion
650 $aParasites
650 $aProteins
650 $aProtozoa
653 $aEvasão imune
653 $aEvolução genômica
653 $aInvasão celular
653 $aParasitas
653 $aProteínas
700 1 $aLOBO, F. P.
700 1 $aRODRIGUES, T. S.
700 1 $aRODRIGUES-LUIZ, G. F.
700 1 $aROCHA, W. D. da
700 1 $aFUJIWARA, R. T.
700 1 $aTEIXEIRA, S. M. R.
700 1 $aBARTHOLOMEU, D. C.
773 $tMolecular Biology and Evolution, Chicago$gv. 30, n. 4, p. 951-963, 2013.
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Embrapa Agricultura Digital (CNPTIA) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Solos. Para informações adicionais entre em contato com cnps.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Solos. |
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Data corrente: |
22/11/2002 |
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Data da última atualização: |
22/11/2002 |
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Autoria: |
NUNES, R. A.; HERNANDEZ TABARES, R.; CARVALHO, I. M. de; BUNKIN, A.; PERSHIN, S.; SILVA, F. C. da; PALMIERI, F.; MILIOLI, V. S.; RAMALHO, A. L. |
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Título: |
Caracterizacao in situ de solos por espectroscopia de fluorescencia induzida por lazer. |
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Ano de publicação: |
1997 |
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Fonte/Imprenta: |
In: CONGRESSO BRASILEIRO DE CIENCIA DO SOLO, 26., 1997. Rio de Janeiro, RJ. Resumos... Rio de Janeiro: Sociedade Brasileira de Ciencia do Solo, 1997. p.421. |
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Idioma: |
Português |
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Conteúdo: |
Sao apresentados os resultados de uma experiencia conjunta, realizada pela EMBRAPA/CNPS e DCMM/PUC - Rio, para a caracterizacao, de solos, atraves de espectroscopia de fluorescencia induzida por laser. Sao tambem apresentados os fundamentos desta tecnica bem como uma descricao do sistema utilizado. O equipamento se apresenta como ferramente que podera se tornar util no estudo de solos. Seu peso relativamente baixo e sua montagem compacta permite que o mesmo possa ser facilmente transportado para o campo com vista a realizacao de medidas de sensoriamento remoto. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01284naa a2200217 a 4500
001 1331461
005 2002-11-22
008 1997 bl uuuu u00u1 u #d
100 1 $aNUNES, R. A.
245 $aCaracterizacao in situ de solos por espectroscopia de fluorescencia induzida por lazer.
260 $c1997
520 $aSao apresentados os resultados de uma experiencia conjunta, realizada pela EMBRAPA/CNPS e DCMM/PUC - Rio, para a caracterizacao, de solos, atraves de espectroscopia de fluorescencia induzida por laser. Sao tambem apresentados os fundamentos desta tecnica bem como uma descricao do sistema utilizado. O equipamento se apresenta como ferramente que podera se tornar util no estudo de solos. Seu peso relativamente baixo e sua montagem compacta permite que o mesmo possa ser facilmente transportado para o campo com vista a realizacao de medidas de sensoriamento remoto.
700 1 $aHERNANDEZ TABARES, R.
700 1 $aCARVALHO, I. M. de
700 1 $aBUNKIN, A.
700 1 $aPERSHIN, S.
700 1 $aSILVA, F. C. da
700 1 $aPALMIERI, F.
700 1 $aMILIOLI, V. S.
700 1 $aRAMALHO, A. L.
773 $tIn: CONGRESSO BRASILEIRO DE CIENCIA DO SOLO, 26., 1997. Rio de Janeiro, RJ. Resumos... Rio de Janeiro: Sociedade Brasileira de Ciencia do Solo, 1997. p.421.
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