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Biblioteca(s): |
Embrapa Meio Ambiente. |
Data corrente: |
15/01/2008 |
Data da última atualização: |
25/03/2014 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
CASTRO, V. L. S. S. de; MELLO, M. A. de; DINIZ, C. A. R.; MORITA, L. H. M.; ZUCCHI, T.; POLI, P. |
Afiliação: |
Vera Lúcia Scherholz Salgado de Castro, Embrapa Meio Ambiente; Michele A. de Melo, Departamento de Parasitologia-ICB-USP; Carlos Diniz, UFSCAR; Lia Morita, UFSCAR; Tânia Zucchi, Departamento de Parasitologia-ICB-USP; Paola Poli, Departamento de Parasitologia-ICB-USP. |
Título: |
Neurodevelopmental effects of perinatal fenarimol exposure on rats. |
Ano de publicação: |
2007 |
Fonte/Imprenta: |
Reproductive Toxicology, Elmsford, v. 23, n. 1, p. 98-105, 2007. |
Idioma: |
Inglês |
Conteúdo: |
Knowledge about the potential toxic effects of fenarimol, a widely used fungicide, is still limited. Fenarimol is an aromatase inhibitor and therefore can affect estrogen/androgen levels in vivo in rodents. In view of these facts, the aim of the present work was to study the effects of fenarimol maternal exposure during different critical phases in the development of central nervous system in rat pups, on early physical and neurobehavioral endpoints essential to their development. For that, the effects of the fungicide fenarimol (150 and 300 mg/kg) were examined at three different developmental stages in the rat: during the first 6 days of gestation, prenatal (15-21 days), or first 6 days of lactation. Three categories of the impact of fenarimol on neonatal growth and neurobehavioral development of offspring were assessed: (1) physical, (2) reflex and strength, and (3) motor coordination. Findings on the pups? physical development did not indicate any significant alterations of the postnatal age at which specific developmental milestones were observed (pinna detachment, development of the fur, eruption of the incisor teeth, opening of the ears and eyes and testes descent). However, there was a reduced rate of weight gain in pups of mothers treated during lactation related to the earlier testing time periods (1-23 days of life). The study of the functional state of the rat pup nervous systems at different stages of postnatal development revealed some neurodevelopmental delays in righting reflex, climbing and grip response and locomotion (20-90 days of life) in the treated groups. Taken together, findings of this study emphasize that, as a result of fenarimol maternal exposure, some neuromuscular and behavioral deficits in nursing pups may occur principally during the last gestational period and lactation. These results could be the basis for further studies on molecular actions of fenarimol in order to predict better the biological consequences of this fungicide. MenosKnowledge about the potential toxic effects of fenarimol, a widely used fungicide, is still limited. Fenarimol is an aromatase inhibitor and therefore can affect estrogen/androgen levels in vivo in rodents. In view of these facts, the aim of the present work was to study the effects of fenarimol maternal exposure during different critical phases in the development of central nervous system in rat pups, on early physical and neurobehavioral endpoints essential to their development. For that, the effects of the fungicide fenarimol (150 and 300 mg/kg) were examined at three different developmental stages in the rat: during the first 6 days of gestation, prenatal (15-21 days), or first 6 days of lactation. Three categories of the impact of fenarimol on neonatal growth and neurobehavioral development of offspring were assessed: (1) physical, (2) reflex and strength, and (3) motor coordination. Findings on the pups? physical development did not indicate any significant alterations of the postnatal age at which specific developmental milestones were observed (pinna detachment, development of the fur, eruption of the incisor teeth, opening of the ears and eyes and testes descent). However, there was a reduced rate of weight gain in pups of mothers treated during lactation related to the earlier testing time periods (1-23 days of life). The study of the functional state of the rat pup nervous systems at different stages of postnatal development revealed some neurodevelopmental delays... Mostrar Tudo |
Palavras-Chave: |
Coordenação motora; Desenvolvimento neurocomportamental; Sistema nervoso central; Teste. |
Thesagro: |
Fungicida; Toxicologia; Toxidez. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02738naa a2200265 a 4500 001 1015999 005 2014-03-25 008 2007 bl uuuu u00u1 u #d 100 1 $aCASTRO, V. L. S. S. de 245 $aNeurodevelopmental effects of perinatal fenarimol exposure on rats. 260 $c2007 520 $aKnowledge about the potential toxic effects of fenarimol, a widely used fungicide, is still limited. Fenarimol is an aromatase inhibitor and therefore can affect estrogen/androgen levels in vivo in rodents. In view of these facts, the aim of the present work was to study the effects of fenarimol maternal exposure during different critical phases in the development of central nervous system in rat pups, on early physical and neurobehavioral endpoints essential to their development. For that, the effects of the fungicide fenarimol (150 and 300 mg/kg) were examined at three different developmental stages in the rat: during the first 6 days of gestation, prenatal (15-21 days), or first 6 days of lactation. Three categories of the impact of fenarimol on neonatal growth and neurobehavioral development of offspring were assessed: (1) physical, (2) reflex and strength, and (3) motor coordination. Findings on the pups? physical development did not indicate any significant alterations of the postnatal age at which specific developmental milestones were observed (pinna detachment, development of the fur, eruption of the incisor teeth, opening of the ears and eyes and testes descent). However, there was a reduced rate of weight gain in pups of mothers treated during lactation related to the earlier testing time periods (1-23 days of life). The study of the functional state of the rat pup nervous systems at different stages of postnatal development revealed some neurodevelopmental delays in righting reflex, climbing and grip response and locomotion (20-90 days of life) in the treated groups. Taken together, findings of this study emphasize that, as a result of fenarimol maternal exposure, some neuromuscular and behavioral deficits in nursing pups may occur principally during the last gestational period and lactation. These results could be the basis for further studies on molecular actions of fenarimol in order to predict better the biological consequences of this fungicide. 650 $aFungicida 650 $aToxicologia 650 $aToxidez 653 $aCoordenação motora 653 $aDesenvolvimento neurocomportamental 653 $aSistema nervoso central 653 $aTeste 700 1 $aMELLO, M. A. de 700 1 $aDINIZ, C. A. R. 700 1 $aMORITA, L. H. M. 700 1 $aZUCCHI, T. 700 1 $aPOLI, P. 773 $tReproductive Toxicology, Elmsford$gv. 23, n. 1, p. 98-105, 2007.
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Embrapa Meio Ambiente (CNPMA) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria de Alimentos. Para informações adicionais entre em contato com ctaa.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
Data corrente: |
25/11/2002 |
Data da última atualização: |
25/11/2002 |
Autoria: |
LIMA, F. H.; WILBERG, V. C.; MATSUURA, F.; ALMEIDA, D. L.; STEPHAN, M. P. |
Título: |
Avaliacao comparativa do potencial de utilizacao de folhas de hortalicas tuberosas para obtencao de isolados proteicos. |
Ano de publicação: |
1998 |
Fonte/Imprenta: |
In: CONGRESSO BRASILEIRO DE CIENCIA E TECNOLOGIA DE ALIMENTOS, 16., 1998, Rio de Janeiro, RJ. Anais... Rio de Janeiro: SBCTA, 1998. v.3, p.1073-1076. |
Idioma: |
Português |
Palavras-Chave: |
Alimento funcional; Folhas; Hortalicas tuberosas. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00691naa a2200193 a 4500 001 1413623 005 2002-11-25 008 1998 bl --- 0-- u #d 100 1 $aLIMA, F. H. 245 $aAvaliacao comparativa do potencial de utilizacao de folhas de hortalicas tuberosas para obtencao de isolados proteicos. 260 $c1998 653 $aAlimento funcional 653 $aFolhas 653 $aHortalicas tuberosas 700 1 $aWILBERG, V. C. 700 1 $aMATSUURA, F. 700 1 $aALMEIDA, D. L. 700 1 $aSTEPHAN, M. P. 773 $tIn: CONGRESSO BRASILEIRO DE CIENCIA E TECNOLOGIA DE ALIMENTOS, 16., 1998, Rio de Janeiro, RJ. Anais... Rio de Janeiro: SBCTA, 1998.$gv.3, p.1073-1076.
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