| |
|
|
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Meio Ambiente. |
|
Data corrente: |
04/10/2006 |
|
Data da última atualização: |
20/09/2017 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
POLI, P.; MELLO, M. A. de; BUSCHINI, A.; CASTRO, V. L. S. S. de; RESTIVO, F. M.; ROSSI, C.; ZUCCHI, T. M. A. D. |
|
Afiliação: |
P. POLI, Dipartimento di Genetica Antropologia Evoluzione, Università degli Studi di Parma, Italia; M. A. de MELLO, Depto. de Parasitologia, Instituto de Ciˆencias Biomédicas, USP; A. BUSCHINI, Dipartimento di Genetica Antropologia Evoluzione, Università degli Studi di Parma, Italia; VERA LUCIA SCHERHOLZ S DE CASTRO, CNPMA; F. M. RESTIVO, Dipartimento di Genetica Antropologia Evoluzione, Università degli Studi di Parma, Italia; C. ROSSI, Dipartimento di Genetica Antropologia Evoluzione, Università degli Studi di Parma, Italia; T. M. A. D. ZUCCHI, Depto de Parasitologia, Instituto de Ci?encias Biomédicas, USP. |
|
Título: |
Evaluation of the genotoxicity induced by the fungicide fenarimol in mammalian and plant cells by use of the single-cell gel electrophoresis assay. |
|
Ano de publicação: |
2003 |
|
Fonte/Imprenta: |
Mutation Research, Amsterdam, v. 540, p. 57-66, 2003. |
|
Idioma: |
Inglês |
|
Conteúdo: |
Fenarimol, a systemic pyrimidine carbinol fungicide, is considered to be not genotoxic or weakly genotoxic, although the available toxicological data are controversial and incomplete. Our results obtained in vitro with leukocytes of two different rodent species (rat and mouse) show that fenarimol affects DNA, as detected by the single-cell gel electrophoresis (SCGE, Comet) assay. This fungicide is able to induce DNA damage in a dose-related manner, with significant effectiveness at 36 nM, but without significant interspecies differences. Simultaneous exposure of rat leukocytes to fenarimol (36-290nM) and a model genotoxic compound (50 ?g/ml bleomycin) produced a supra-additive cytotoxic and genotoxic effect. This supports previous findings suggesting possible co-toxic, co-mutagenic, cancer-promoting and co-carcinogenic potential of fenarimol, and modification of the effects of other xenobiotics found to be influenced by this agrotoxic chemical, with consequent different toxicological events. The potential for DNA strand breaks to act as a biomarker of genetic toxicity in plants in vivo was also considered, in view of the fact that higher plants represent reliable sensors in an ecosystem. Significant DNA breakage was observed in the nuclei of Impatiens balsamina leaves after in vivo treatment with fenarimol (145 nM, 1 h). More than 50% of the cells showed such DNA damage. |
|
Thesagro: |
Análise química; Eletroforese; Fungicida; Toxidez. |
|
Categoria do assunto: |
W Química e Física |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/163846/1/Poli-Evaluation-6441.pdf
|
|
Marc: |
LEADER 02141naa a2200241 a 4500
001 1015095
005 2017-09-20
008 2003 bl uuuu u00u1 u #d
100 1 $aPOLI, P.
245 $aEvaluation of the genotoxicity induced by the fungicide fenarimol in mammalian and plant cells by use of the single-cell gel electrophoresis assay.$h[electronic resource]
260 $c2003
520 $aFenarimol, a systemic pyrimidine carbinol fungicide, is considered to be not genotoxic or weakly genotoxic, although the available toxicological data are controversial and incomplete. Our results obtained in vitro with leukocytes of two different rodent species (rat and mouse) show that fenarimol affects DNA, as detected by the single-cell gel electrophoresis (SCGE, Comet) assay. This fungicide is able to induce DNA damage in a dose-related manner, with significant effectiveness at 36 nM, but without significant interspecies differences. Simultaneous exposure of rat leukocytes to fenarimol (36-290nM) and a model genotoxic compound (50 ?g/ml bleomycin) produced a supra-additive cytotoxic and genotoxic effect. This supports previous findings suggesting possible co-toxic, co-mutagenic, cancer-promoting and co-carcinogenic potential of fenarimol, and modification of the effects of other xenobiotics found to be influenced by this agrotoxic chemical, with consequent different toxicological events. The potential for DNA strand breaks to act as a biomarker of genetic toxicity in plants in vivo was also considered, in view of the fact that higher plants represent reliable sensors in an ecosystem. Significant DNA breakage was observed in the nuclei of Impatiens balsamina leaves after in vivo treatment with fenarimol (145 nM, 1 h). More than 50% of the cells showed such DNA damage.
650 $aAnálise química
650 $aEletroforese
650 $aFungicida
650 $aToxidez
700 1 $aMELLO, M. A. de
700 1 $aBUSCHINI, A.
700 1 $aCASTRO, V. L. S. S. de
700 1 $aRESTIVO, F. M.
700 1 $aROSSI, C.
700 1 $aZUCCHI, T. M. A. D.
773 $tMutation Research, Amsterdam$gv. 540, p. 57-66, 2003.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Meio Ambiente (CNPMA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio-Norte. Para informações adicionais entre em contato com cpamn.biblioteca@embrapa.br. |
Registro Completo
|
Biblioteca(s): |
Embrapa Meio-Norte. |
|
Data corrente: |
10/10/1996 |
|
Data da última atualização: |
16/01/2024 |
|
Autoria: |
ARAUJO, A. G. de. |
|
Afiliação: |
EMBRAPA-UEPAE de Teresina. |
|
Título: |
Avaliacao de sistemas de cultivares para a microrregiao do Medio Parnaiba piauiense. |
|
Ano de publicação: |
1983 |
|
Fonte/Imprenta: |
In: REUNIAO SOBRE CULTURAS CONSORCIADAS NO NORDESTE, 1., 1983, Teresina. Anais. Teresina: EMBRAPA-UEPAE de Teresina, 1983. p. 53. |
|
Idioma: |
Português |
|
Palavras-Chave: |
Brasil; Consorcio; Cultivo; Cultura alimentar; Medio Parnaiba; Piaui; Sistema. |
|
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
|
Marc: |
LEADER 00607naa a2200193 a 4500
001 1049532
005 2024-01-16
008 1983 bl uuuu u00u1 u #d
100 1 $aARAUJO, A. G. de
245 $aAvaliacao de sistemas de cultivares para a microrregiao do Medio Parnaiba piauiense.
260 $c1983
653 $aBrasil
653 $aConsorcio
653 $aCultivo
653 $aCultura alimentar
653 $aMedio Parnaiba
653 $aPiaui
653 $aSistema
773 $tIn: REUNIAO SOBRE CULTURAS CONSORCIADAS NO NORDESTE, 1., 1983, Teresina. Anais. Teresina: EMBRAPA-UEPAE de Teresina, 1983. p. 53.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Meio-Norte (CPAMN) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
