Data/hora: 05/06/2024 04:30:47

Biblioteca(s): | Embrapa Agricultura Digital.
Data corrente: | 26/03/2009
Data da última atualização: | 15/01/2020
Autoria: | MANCINI, A. L.; JARDINE, J. G.; MAZONI, I.; BORRO, L. C.; ALVARENGA, D.; CECILIO, P. L.; PELLIGRINELLI, T. V.; NESHICH, G.
Afiliação: | ADAUTO LUIZ MANCINI, CNPTIA; JOSE GILBERTO JARDINE, CNPTIA; IVAN MAZONI, CNPTIA; LUIZ CÉSAR BORRO; DANIEL ALVARENGA; PABLO LIRA CECÍLIO; THAÍS VITAL PELLIGRINELLI; GORAN NESHICH, CNPTIA.
Título: | Structure descriptors of chameleon sequences.
Ano de publicação: | 2008
Fonte/Imprenta: | In: RED IBEROAMERICANA DE BIOINFORMÁTICA CONGRESS, 5., 2008, Chile. Program and abstracts... Santiago: Pontificia Universidad Católica de Chile, 2008.
Páginas: | Não paginado.
Idioma: | Inglês
Notas: | RIB 2008.
Conteúdo: | It has been know since the early work by Sander and Kabsch in 1984 that some identical sequence motifs make completely different local (but extented) folds. In that work, Sander and Kabsch showed the existence of a number of pentapeptides, capable of nucleating both alpha helix and beta strand in different sequence and structure constellations. However, the authors had at that time a very limited universe on which to base their conclusions; namely, the size of the PDB at that time (1984) was only 154 protein structure available. In 2008 the number of available structure is 51,079 (May 27th), 47137containing proteins only. Consequenly, the database is 306 times larger and we took full advantage of this fact. In order to analyze chameleon sequences, we established very strict rules and considered only those ones that passed the test of consensus among HSSP and STRIDE definitions for the Secondary Structure Elements. This is a major difference in our approach versus that of Sander and Kabsch. We then created a data mart of sequences and respective structures with variable size and subjected them to analysis of structure descriptors stored in STING_RDB. Results are discussed in terms of the influence that a local 3D environment has on SSE necleation.
Palavras-Chave: | Bioinformática; Proteinas.
Thesaurus Nal: | Bioinformatics; Proteins.
Categoria do assunto: | X Pesquisa, Tecnologia e Engenharia
Registro original: | Embrapa Agricultura Digital (CNPTIA)

Exemplares:

CNPTIA - (12691-1) - UPC - RA - PP -  -  - 2009.00059 - DES
CNPTIA - (12691-2) - UPC - RA - DD -  -  -  - DIS