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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
11/10/1996 |
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Data da última atualização: |
11/10/1996 |
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Autoria: |
PEREZ, J.; GARCIA MARIN, J. F.; BADIOLA, J. J. |
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Título: |
Description and classification of different types of lesion associated with natural paratuberculosis infection in sheep. |
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Ano de publicação: |
1996 |
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Fonte/Imprenta: |
Journal of Comparative Pathology, v.114, n.2, p.107-122, 1996. |
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Idioma: |
Inglês |
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Conteúdo: |
Paratuberculosis lesions in naturally infected sheep were classified histo- logicaIly. Adult sheep (n=166) culled for various reasons, from four flocks in which clinicat cases of the disease had occurred, were studied. Eight-two sheep (49.4%) showed lesions that could be divided into three main categories. Type 1 lesions, found in 24.1% of the se animaIs, consisted of small granulomata formed by macrophages and were located exclusively in the ileocaecal Peyer's patch. ln type 2 lesions, round in 4.8% of the sheep, granulomata were also observed in the mucosa associated with Peyer's patches. Type 3 les ions were characterized by granulomata in areas of the mucosa associated with, and also distinct from, the Peyer's patches. Three subtypes of type 3 lesions were recognized. ln subtype 3a, round in 4.2% of the sheep, multifocal granulomata appeared in different areas of the lamina propria; they were not apparently associated with lymphoid tissue, and neither did they modify the morphology of the affected areas. Subtype 3b, found in 13.9% of animaIs, consisted of large numbers of macrophages, widespread in the lamina propria; in subtype 3c (2-4% of sheep) lymphocytes were the main inflammatory ceIl, with Saille macrophages scattered amongst them. ln subtypes 3a and b, villi were distended and the mucosa appeared thickened. Mycobacteria could be demonstrated in tissue sections from ail the samples with subtype 3b lesions and in almost ail of those with type 2 and 3a lesions; these organisms were absent or sparse, however, in type 1 and 3c lesions. Macroscopical lesions were clearly visible only in sheep with type 3b and 3c lesions. Mycobacterium paratuberculosis was cultured from ail the animaIs with type 3 lesions, from 87.5% of those with type 2 lesions, and from 47.5% of those with type 1. Type 3b lesions resembled the "borderline-lepromatous" form of myco- bacterial lesions, whereas type 3c lesions resembled the "borderline-tuber-culoid" form. The relationship between intestinal lymphoid tissue and paratuberculosis lesions is discussed, and the diagnostic importance of histological examination of the ileocaecal valve emphasized. MenosParatuberculosis lesions in naturally infected sheep were classified histo- logicaIly. Adult sheep (n=166) culled for various reasons, from four flocks in which clinicat cases of the disease had occurred, were studied. Eight-two sheep (49.4%) showed lesions that could be divided into three main categories. Type 1 lesions, found in 24.1% of the se animaIs, consisted of small granulomata formed by macrophages and were located exclusively in the ileocaecal Peyer's patch. ln type 2 lesions, round in 4.8% of the sheep, granulomata were also observed in the mucosa associated with Peyer's patches. Type 3 les ions were characterized by granulomata in areas of the mucosa associated with, and also distinct from, the Peyer's patches. Three subtypes of type 3 lesions were recognized. ln subtype 3a, round in 4.2% of the sheep, multifocal granulomata appeared in different areas of the lamina propria; they were not apparently associated with lymphoid tissue, and neither did they modify the morphology of the affected areas. Subtype 3b, found in 13.9% of animaIs, consisted of large numbers of macrophages, widespread in the lamina propria; in subtype 3c (2-4% of sheep) lymphocytes were the main inflammatory ceIl, with Saille macrophages scattered amongst them. ln subtypes 3a and b, villi were distended and the mucosa appeared thickened. Mycobacteria could be demonstrated in tissue sections from ail the samples with subtype 3b lesions and in almost ail of those with type 2 and 3a lesions; thes... Mostrar Tudo |
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Thesagro: |
Doença; Ovino; Salmonelose. |
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Thesaurus Nal: |
paratuberculosis. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02741naa a2200193 a 4500
001 1516561
005 1996-10-11
008 1996 bl uuuu u00u1 u #d
100 1 $aPEREZ, J.
245 $aDescription and classification of different types of lesion associated with natural paratuberculosis infection in sheep.
260 $c1996
520 $aParatuberculosis lesions in naturally infected sheep were classified histo- logicaIly. Adult sheep (n=166) culled for various reasons, from four flocks in which clinicat cases of the disease had occurred, were studied. Eight-two sheep (49.4%) showed lesions that could be divided into three main categories. Type 1 lesions, found in 24.1% of the se animaIs, consisted of small granulomata formed by macrophages and were located exclusively in the ileocaecal Peyer's patch. ln type 2 lesions, round in 4.8% of the sheep, granulomata were also observed in the mucosa associated with Peyer's patches. Type 3 les ions were characterized by granulomata in areas of the mucosa associated with, and also distinct from, the Peyer's patches. Three subtypes of type 3 lesions were recognized. ln subtype 3a, round in 4.2% of the sheep, multifocal granulomata appeared in different areas of the lamina propria; they were not apparently associated with lymphoid tissue, and neither did they modify the morphology of the affected areas. Subtype 3b, found in 13.9% of animaIs, consisted of large numbers of macrophages, widespread in the lamina propria; in subtype 3c (2-4% of sheep) lymphocytes were the main inflammatory ceIl, with Saille macrophages scattered amongst them. ln subtypes 3a and b, villi were distended and the mucosa appeared thickened. Mycobacteria could be demonstrated in tissue sections from ail the samples with subtype 3b lesions and in almost ail of those with type 2 and 3a lesions; these organisms were absent or sparse, however, in type 1 and 3c lesions. Macroscopical lesions were clearly visible only in sheep with type 3b and 3c lesions. Mycobacterium paratuberculosis was cultured from ail the animaIs with type 3 lesions, from 87.5% of those with type 2 lesions, and from 47.5% of those with type 1. Type 3b lesions resembled the "borderline-lepromatous" form of myco- bacterial lesions, whereas type 3c lesions resembled the "borderline-tuber-culoid" form. The relationship between intestinal lymphoid tissue and paratuberculosis lesions is discussed, and the diagnostic importance of histological examination of the ileocaecal valve emphasized.
650 $aparatuberculosis
650 $aDoença
650 $aOvino
650 $aSalmonelose
700 1 $aGARCIA MARIN, J. F.
700 1 $aBADIOLA, J. J.
773 $tJournal of Comparative Pathology$gv.114, n.2, p.107-122, 1996.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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