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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
17/09/2018 |
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Data da última atualização: |
17/09/2018 |
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Autoria: |
PETERSON, D. W.; PENNY, R. H.; DAY, J. B.; MANTLE, P. G. |
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Título: |
A comparative study of sheep and pigs given the tremorgenic mycotoxins verruculogen and penitrem A. |
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Ano de publicação: |
1982 |
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Fonte/Imprenta: |
Research in Veterinary Science, v. 33, n. 2, p. 183-187, Sept. 1982. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The moulds Penicillium simplicissimum and P crustosum and the tremorgenic mycotoxins, verruculogen and penitrem A, isolated from them, were given to sheep and pigs to compare their potencies. Pigs were generally less susceptible and in both species penitrem A was less potent than verruculogen. Five-month-old lambs seemed more susceptible to mycelium containing verruculogen than were 15-month-old sheep given a similar oral dose relative to bodyweight. Repeated daily dosing of lambs and sheep for five days with P simplicissimum failed to enhance the effect, indicating that verruculogen toxicity was not cumulative. Long and short acting barbiturate anaesthesia blocked the effects of lethal doses of tremorgens. Sedation with diazepam diminished, but did not block, mycotoxin-induced tremors suggesting that there was no specific action of this anticonvulsant sedative on tremorgens. |
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Palavras-Chave: |
Chemically induced; Dose-Response Relationship; Tremor; Tremortin; Verruculogen. |
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Thesaurus Nal: |
Barbiturates; Diazepam; Drug antagonism; Indoles; Mycotoxins; Penicillium; Pharmacology; Sheep diseases; Swine diseases; Toxicity. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01814naa a2200337 a 4500
001 2095848
005 2018-09-17
008 1982 bl uuuu u00u1 u #d
100 1 $aPETERSON, D. W.
245 $aA comparative study of sheep and pigs given the tremorgenic mycotoxins verruculogen and penitrem A.
260 $c1982
520 $aAbstract: The moulds Penicillium simplicissimum and P crustosum and the tremorgenic mycotoxins, verruculogen and penitrem A, isolated from them, were given to sheep and pigs to compare their potencies. Pigs were generally less susceptible and in both species penitrem A was less potent than verruculogen. Five-month-old lambs seemed more susceptible to mycelium containing verruculogen than were 15-month-old sheep given a similar oral dose relative to bodyweight. Repeated daily dosing of lambs and sheep for five days with P simplicissimum failed to enhance the effect, indicating that verruculogen toxicity was not cumulative. Long and short acting barbiturate anaesthesia blocked the effects of lethal doses of tremorgens. Sedation with diazepam diminished, but did not block, mycotoxin-induced tremors suggesting that there was no specific action of this anticonvulsant sedative on tremorgens.
650 $aBarbiturates
650 $aDiazepam
650 $aDrug antagonism
650 $aIndoles
650 $aMycotoxins
650 $aPenicillium
650 $aPharmacology
650 $aSheep diseases
650 $aSwine diseases
650 $aToxicity
653 $aChemically induced
653 $aDose-Response Relationship
653 $aTremor
653 $aTremortin
653 $aVerruculogen
700 1 $aPENNY, R. H.
700 1 $aDAY, J. B.
700 1 $aMANTLE, P. G.
773 $tResearch in Veterinary Science$gv. 33, n. 2, p. 183-187, Sept. 1982.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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