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| 1. |  | LUCAS, D. D. P.; MALDANER, I. V.; TRENTIN, R.; HINNAH, F. D.; SILVA, J. R. da. Excedente hídrico em diferentes solos e épocas de semeadura do girassol no Rio Grande do Sul. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 50, n. 6, p. 431-440, jun. 2015. Título em inglês: Water excess in different soils and sowing times for sunflower in the state of Rio Grande do Sul, Brazil.| Biblioteca(s): Embrapa Unidades Centrais. |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
24/11/2014 |
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Data da última atualização: |
05/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
CARVALHO, W. A.; DOMINGUES, R.; PRATA, M. C. de A.; SILVA, M. V. G. B.; OLIVEIRA, G. C. de; GUIMARÃES, S. E. F.; MACHADO, M. A. |
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Afiliação: |
WANESSA ARAUJO CARVALHO, CNPGL; ROBERT DOMINGUES, CPPSUL; MARCIA CRISTINA DE AZEVEDO PRATA, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; GUILHERME CORRÊA DE OLIVEIRA, FIOCRUZ; SIMONE ELIZA FACIONI GUIMARÃES, UFV; MARCO ANTONIO MACHADO, CNPGL. |
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Título: |
Microarray analysis of tick-infested skin in resistant and susceptible cattle confirms the role of inflammatory pathways in immune activation and larval rejection. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Veterinary Parasitology, Amsterdam, v. 205, n. 1/2, p. 307-317, 2014. |
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DOI: |
10.1016/j.vetpar.2014.07.018 |
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Idioma: |
Inglês |
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Conteúdo: |
Tick bites promote activation of an inflammatory process that is influenced by bovine genetic composition and its history of previous exposure. Taurine and indicine breeds are known to differ on its immune response development against Rhipicephalus microplus. Nevertheless, further investigation about the complex molecular pathways involved in the development of immune response to tick infestation in cattle presenting the same genetic background is mandatory. The aim of this work was to access the early immune response triggered by R. microplus larvae attachment in previously selected resistant and susceptible animals in a bovine F2 population derived from Gyr (Bos indicus)×Holstein (Bos taurus) crosses. Microarray data analysis of RNA samples from tick infested skin was used to evaluate the gene expression at 0, 24 and 48h after R. microplus larvae attachment. Our experimental design allowed us to deeply explore the immune response related to R. microplus infestation avoiding the innate differences between these breeds. The differentially expressed genes found reveal networks and pathways that suggest a key role of lipid metabolism in inflammation control and impairment of tick infestation in resistant animals. Acute phase response also seems to be impaired in susceptible animals. These results provide new insights about early immune response against ticks and raise the possibility of using immunomodulation processes to improve and develop novel tools for tick control. |
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Palavras-Chave: |
Imunomodulação. |
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Thesagro: |
Bovino; Imunologia. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
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001 2000821
005 2024-02-05
008 2014 bl uuuu u00u1 u #d
024 7 $a10.1016/j.vetpar.2014.07.018$2DOI
100 1 $aCARVALHO, W. A.
245 $aMicroarray analysis of tick-infested skin in resistant and susceptible cattle confirms the role of inflammatory pathways in immune activation and larval rejection.$h[electronic resource]
260 $c2014
520 $aTick bites promote activation of an inflammatory process that is influenced by bovine genetic composition and its history of previous exposure. Taurine and indicine breeds are known to differ on its immune response development against Rhipicephalus microplus. Nevertheless, further investigation about the complex molecular pathways involved in the development of immune response to tick infestation in cattle presenting the same genetic background is mandatory. The aim of this work was to access the early immune response triggered by R. microplus larvae attachment in previously selected resistant and susceptible animals in a bovine F2 population derived from Gyr (Bos indicus)×Holstein (Bos taurus) crosses. Microarray data analysis of RNA samples from tick infested skin was used to evaluate the gene expression at 0, 24 and 48h after R. microplus larvae attachment. Our experimental design allowed us to deeply explore the immune response related to R. microplus infestation avoiding the innate differences between these breeds. The differentially expressed genes found reveal networks and pathways that suggest a key role of lipid metabolism in inflammation control and impairment of tick infestation in resistant animals. Acute phase response also seems to be impaired in susceptible animals. These results provide new insights about early immune response against ticks and raise the possibility of using immunomodulation processes to improve and develop novel tools for tick control.
650 $aBovino
650 $aImunologia
653 $aImunomodulação
700 1 $aDOMINGUES, R.
700 1 $aPRATA, M. C. de A.
700 1 $aSILVA, M. V. G. B.
700 1 $aOLIVEIRA, G. C. de
700 1 $aGUIMARÃES, S. E. F.
700 1 $aMACHADO, M. A.
773 $tVeterinary Parasitology, Amsterdam$gv. 205, n. 1/2, p. 307-317, 2014.
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