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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
08/11/2021 |
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Data da última atualização: |
25/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MALAFATTI, J. O. D.; RUELLAS, T. M. de O.; MEIRELLES, M. R.; THOMAZI, A. C.; RENDA, C. G.; PARIS, E. C. |
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Afiliação: |
ADRIANA COATRINI THOMAZI, CNPDIA; ELAINE CRISTINA PARIS, CNPDIA. |
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Título: |
Nanocarriers of Eu3+ doped silica nanoparticles modified by APTES for luminescent monitoring of cloxacillin. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
AIMS Materials Science, v. 8, n. 5. |
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Páginas: |
760?775 |
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ISSN: |
2372-0484 |
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DOI: |
10.3934/matersci.2021046 |
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Idioma: |
Inglês |
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Conteúdo: |
Drug nanocarriers have been continuously improved to promote satisfactory release control. In this sense, luminescent materials have become an alternative option in clinical trials due to their ability to monitor drug delivery. Among the nanocarriers, silica stands out for structural stability, dispersibility, and surface reactivity. When using ceramic nanocarriers, one of the challenges is their interaction and selectivity capability for organic molecules, such as drugs. In order to overcome such adversity, superficial modifications can be carried out to enable a higher affinity for the desired drug. Thus, the present study aimed to obtain silica nanoparticles (NPs) doped with low concentrations of europium (III) superficially modified by (3-aminopropyl)triethoxysilane (APTES) to assess their interaction with the model drug cloxacillin benzathine. This drug was chosen because it is part of the ampicillin family and is commonly used in several treatments. Nearspherical and homogeneous silica NPs were obtained via sol-gel synthesis, with particle sizes of approximately 21 nm. It was possible to verify the fluorescence capacity of the silica NPs when doped with europium (III) in a mole percent that varied from 0.5 to 3.0%. A 10% volume percent of APTES caused the silica nanoparticles to increase the degree of hydrophobicity, with a shift in the contact angle from 8° to 51°. After surface modification by APTES, the silica nanocarrier (10 gꞏL−1) achieved a satisfactory degree of CLOX incorporation (25 gꞏL−1), increasing the adsorptive capacity to values above 50%. Therefore, silica NPs doped with europium (III) in a low percent of 0.5% (mole) modified by APTES showed promising results as an alternative option for trials and clinical studies of drug incorporation. MenosDrug nanocarriers have been continuously improved to promote satisfactory release control. In this sense, luminescent materials have become an alternative option in clinical trials due to their ability to monitor drug delivery. Among the nanocarriers, silica stands out for structural stability, dispersibility, and surface reactivity. When using ceramic nanocarriers, one of the challenges is their interaction and selectivity capability for organic molecules, such as drugs. In order to overcome such adversity, superficial modifications can be carried out to enable a higher affinity for the desired drug. Thus, the present study aimed to obtain silica nanoparticles (NPs) doped with low concentrations of europium (III) superficially modified by (3-aminopropyl)triethoxysilane (APTES) to assess their interaction with the model drug cloxacillin benzathine. This drug was chosen because it is part of the ampicillin family and is commonly used in several treatments. Nearspherical and homogeneous silica NPs were obtained via sol-gel synthesis, with particle sizes of approximately 21 nm. It was possible to verify the fluorescence capacity of the silica NPs when doped with europium (III) in a mole percent that varied from 0.5 to 3.0%. A 10% volume percent of APTES caused the silica nanoparticles to increase the degree of hydrophobicity, with a shift in the contact angle from 8° to 51°. After surface modification by APTES, the silica nanocarrier (10 gꞏL−1) achieved a satisfactory degree of... Mostrar Tudo |
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Palavras-Chave: |
Luminescent materials; Surface modification. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02525naa a2200241 a 4500
001 2135885
005 2022-11-25
008 2021 bl uuuu u00u1 u #d
022 $a2372-0484
024 7 $a10.3934/matersci.2021046$2DOI
100 1 $aMALAFATTI, J. O. D.
245 $aNanocarriers of Eu3+ doped silica nanoparticles modified by APTES for luminescent monitoring of cloxacillin.$h[electronic resource]
260 $c2021
300 $a760?775
520 $aDrug nanocarriers have been continuously improved to promote satisfactory release control. In this sense, luminescent materials have become an alternative option in clinical trials due to their ability to monitor drug delivery. Among the nanocarriers, silica stands out for structural stability, dispersibility, and surface reactivity. When using ceramic nanocarriers, one of the challenges is their interaction and selectivity capability for organic molecules, such as drugs. In order to overcome such adversity, superficial modifications can be carried out to enable a higher affinity for the desired drug. Thus, the present study aimed to obtain silica nanoparticles (NPs) doped with low concentrations of europium (III) superficially modified by (3-aminopropyl)triethoxysilane (APTES) to assess their interaction with the model drug cloxacillin benzathine. This drug was chosen because it is part of the ampicillin family and is commonly used in several treatments. Nearspherical and homogeneous silica NPs were obtained via sol-gel synthesis, with particle sizes of approximately 21 nm. It was possible to verify the fluorescence capacity of the silica NPs when doped with europium (III) in a mole percent that varied from 0.5 to 3.0%. A 10% volume percent of APTES caused the silica nanoparticles to increase the degree of hydrophobicity, with a shift in the contact angle from 8° to 51°. After surface modification by APTES, the silica nanocarrier (10 gꞏL−1) achieved a satisfactory degree of CLOX incorporation (25 gꞏL−1), increasing the adsorptive capacity to values above 50%. Therefore, silica NPs doped with europium (III) in a low percent of 0.5% (mole) modified by APTES showed promising results as an alternative option for trials and clinical studies of drug incorporation.
653 $aLuminescent materials
653 $aSurface modification
700 1 $aRUELLAS, T. M. de O.
700 1 $aMEIRELLES, M. R.
700 1 $aTHOMAZI, A. C.
700 1 $aRENDA, C. G.
700 1 $aPARIS, E. C.
773 $tAIMS Materials Science$gv. 8, n. 5.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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| Registros recuperados : 52 | |
| 41. |  | PARIS, E. C.; MALAFATTI, J. O. D.; SCIENA, C. R.; NEVES JUNIOR, L. F.; ZENATTI, A.; ESCOTE, M. T.; MOREIRA, A. J.; FRESCHI, G. P. G. Nb2O5 nanoparticles decorated with magnetic ferrites for wastewater photocatalytic remediation. Environmental Science and Pollution Research,v. 28, n. 19, 2021. p. 23731-23741| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 42. | | BRITO, S. C.; MALAFATTI, J. O. D.; BRASIL, E. M.; BRESOLIN, J. D.; SIVIERI, K.; PARIS, E. C.; FERREIRA, M. D. A Comprehensive Approach to the SiO2/Ag Nanoparticles? Interaction on Polyvinyl Chloride Films and the Effects of Antimicrobial Activity. Brazilian Journal of Physics, v. 53,111, 2023. 1 - 9| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 3 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 44. | | BRITO, S. C.; MALAFATTI, J. O. D.; ARAB, F. E.; BRESOLIN, J. D.; PARIS, E. C.; SOUZA, C. W. O. de; FERREIRA, M. D. One-pot synthesis of CuO, ZnO, and Ag nanoparticles: structural, morphological, and bactericidal evaluation. Inorganic and Nano-Metal Chemistry, v. 52, 2022. 12 p.| Tipo: Artigo em Periódico Indexado |
| Biblioteca(s): Embrapa Instrumentação. |
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| 46. | | MOREIRA, A. J.; MALAFATTI, J. O. D.; GIRALDI, T. R.; PARIS, E. C.; PEREIRA, E. C.; MENDONÇA, V. R.; MASTELARO, V. R.; FRESCHI, G. P. G. Prozac® photodegradation mediated by Mn-doped TiO2 nanoparticles: Evaluation of by-products and mechanisms proposal. Journal of Environmental Chemical Engineering, v. 8, 104543, 2020. 1 - 13| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 47. | | MALAFATTI, J. O. D.; MOREIRA, A. J.; SCIENA, C. R.; SILVA, T. E. M.; FRESCHI, G. P. G.; PEREIRA, E. C.; PARIS, E. C. Prozac® removal promoted by HAP:Nb2O5 nanoparticles system: by products, mechanism, and cytotoxicity assessment. Journal of Environmental Chemical Engineering, v. 9, e104820, 2021. 1-11| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 48. | | MALAFATTI, J. O. D.; RUELLAS, T. M. O.; SCHILDT, L. F. L.; DOMINGUES, M. A.; MARINHO, B. S.; MEIRELLES, M. R.; PARIS, E. C. Propriedades mecânicas de filmes de amido termoplástico na presença de ureia. In: ARENARE, E. C. C. (org.). A Geração de Novos Conhecimentos na Química 2. Ponta Grossa, PR: Atena, 2021. 356 p.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Instrumentação. |
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| 49. | | RENDA, C. G.; RUELLAS, T. M. O.; MALAFATTI, J. O. D.; ARAÚJO, C. S. S.; SILVA, G. L. da; FIGUEIRA, B. A. M.; QUARANTE, S.; PARIS, E. C. A Zero-Cost Adsorbing Hydroxyapatite-Based Material from Amazon Fishery Waste for Water Remediation and Nutrient Release for Agriculture. Physchem, v. 3, 2023. 60 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 50. | | RUELLAS, T. M. O.; PEÇANHA, L. O. O.; DOMINGOS, G. H. S.; SCIENA, C. R.; MALAFATTI, J. O. D.; PARIS, E. C.; MAESTRELLI, S. C.; GIRALDI, T. R. Zinc oxide pieces obtained by pressing and slip casting: physical, structural and photocatalytic properties. Environmental Technology, 2019. 1-23 Published online: 07 Nov 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 51. | | SCIENA, C. R.; MALAFATTI, J. O. D.; NEVES JUNIOR, L. F.; CARRA, M. A. S.; SANTOS, L. C.; CORREA, D. S.; MARCONCINI, J. M.; OLIVEIRA, C. R. de; PARIS, E. C. Biodegradable sachets composed by starch: pectin for controlling/slow release of phosphorus ions from hydroxyapatite nanoparticles. In: BRAZILIAN MRS MEETING - SBPMAT, 14, 2015, Rio de Janeiro. Program book... Rio de Janeiro: SBPMat, 2015. não paginado. Entrada de autor padronizada: RIBEIRO, C.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 52. | | OLIVEIRA FILHO, J. G. de; BERTOLO, M. R. V.; BRITO, S. C.; MALAFATTI, J. O. D.; BERTAZZO, G. B.; COLACIQUE, M. N.; PARIS, E. C.; BOGUSZ JUNIOR, S.; FERREIRA, M. D. Recent advances in the application of nanotechnology to reduce fruit and vegetable losses during post-harvest. Brazilian Journal of Physics, v. 52, 126, 2022. 11 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Instrumentação. |
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| Registros recuperados : 52 | |
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