Data/hora: 12/06/2024 08:56:51

Biblioteca(s): 	Embrapa Amazônia Ocidental.	
Data corrente: 	13/07/2006	
Data da última atualização: 	06/01/2015	
Autoria: 	FUKUMASU, H.; SILVA, T. C. da; AVANZO, J. L.; LIMA, C. E. de; MACKOWIAK, I. I.; ATROCH, A.; SPINOSA, H. de S.; MORENO, F. S.; DAGLI, M. L. Z.	
Afiliação: 	Heidge Fukumasu, USP; Tereza Cristina da Silva, USP; José Luis Avanzo, USP; Cyntia Esteves de Lima, USP; Ivone Isabel Mackowiak, USP; André Atroch, CPAA; Helenice de Souza Spinosa, USP; Fernando Salvador Moreno, USP; Maria Lucia Zaidan Dagli, USP.	
Título: 	Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guarana, on mouse hepatocarcinogenesis.	
Ano de publicação: 	2006	
Fonte/Imprenta: 	Cancer Letters, v. 233, n. 1, p. 158-164, fev. 2006.	
Idioma: 	Inglês	
Conteúdo: 	Guarana (Paullinia cupana) is originally front Amazon, Brazil. Its effects on mouse hepatocarcinogenesis have been investigated in this study. Mice were treated with N-nitrosodiethylamine (DEN), received three different doses of P. cupana added to commercial food, and euthanized after 25 weeks. Gross lesions were quantified, and preneoplastic lesions (PNL) were histologically measured. Cellular proliferation was evaluated by immunobloting for the proliferating cell nuclear antigen (PCNA). The incidence and multiplicity of macroscopic lesions were reduced. The PNL number and PCNA expression were reduced in the highest P. cupana dose. According to these results, guarana presented inhibitory effects on DEN hepatocarcinogenesis in mice.	
Palavras-Chave: 	Prevenção.	
Thesagro: 	Cafeína; Câncer; Carcinôgeno; Fígado; Guaraná; Paullinia Cupana.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Amazônia Ocidental (CPAA)	
Exemplares: 	CPAA - (15002-1) - UPC - AP - PP - S8431 -  - S8431 - DIS