Data/hora: 04/06/2024 18:13:25

Biblioteca(s): | Embrapa Gado de Leite.
Data corrente: | 20/04/2010
Data da última atualização: | 16/02/2024
Autoria: | ALVES, C. C. de S.; AZEVEDO, A. L. S.; RODRIGUES, M. F.; MACHADO, R. P.; SOUZA, M. A.; MACHADO, M. A.; TEIXEIRA, H. C.; FERREIRA, A. P.
Afiliação: | CAIO CÉSAR DE SOUZA ALVES, UFJF; ANA LUISA SOUSA AZEVEDO, CNPGL; MICHELE F. RODRIGUES, UFJF; RACHEL P. MACHADO, UFJF; SUPREMA; MARIA A. SOUZA, UFJF; MARCO ANTONIO MACHADO, CNPGL; HENRIQUE C. TEIXEIRA, UFJF; ANA P. FERREIRA, UFJF.
Título: | Cellular and humoral immune responses during intrathoracic paracoccidioidomycosis in BALB/c mice.
Ano de publicação: | 2009
Fonte/Imprenta: | Comparative Immunology, Microbiology and Infectious Discases, v. 32, n. 6, p. 513-525, 2009.
DOI: | https://doi.org/10.1016/j.cimid.2008.07.006
Idioma: | Inglês
Conteúdo: | Paracoccidioidomycosis is a chronic infection that primarily affects the lungs. Here we investigated cellular and humoral immune responses after intrathoracic Paracoccidioidesbrasiliensis infection in BALB/c mice. P. brasiliensis-colony-forming units (CFUs), fungal DNA and granulomas in lungs increased progressively, peaking at day 90 postinfection (p.i.). IFN-γ production was highest on day 15 p.i., declining thereafter. The kinetics of the NO production was similar to that described for IFN-γ. In contrast, IL-10 increased from day 45 p.i. reaching a peak at day 90. Levels of serum IgG1 were higher than IgG2a between days 30 and 90 p.i. 30% of mice died by day 90 p.i. These data indicate that infection with P. brasiliensis by the intrathoracic route shows high IFN-γ and NO production at day 15 p.i., unable to control multiplication of fungi, which appears to be associated with a progressive increase in IL-10 and in the number and complexity of granulomas.
Palavras-Chave: | Antibody response; IFN-y; IL-10; Intrathoracic route.
Thesaurus Nal: | Paracoccidioides brasiliensis.
Categoria do assunto: | H Saúde e Patologia
URL: | http://ainfo.cnptia.embrapa.br/digital/bitstream/doc/697051/1/Cellular-and-humoral-immune-responses-during-intrathoracic-paracoccidioidomycosis.pdf
Registro original: | Embrapa Gado de Leite (CNPGL)
Exemplares: | CNPGL - (16947-1) - UPC - AP - DD -  -  -  - DIS