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Registro Completo |
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
30/04/2018 |
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Data da última atualização: |
30/04/2018 |
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Autoria: |
NOGUEIRA, S. S. S.; SOUSA, M. G.; GAVA, F. N.; ROSA, F. A.; MELO, G. D.; DITTRICH, G.; MACHADO, G. F.; CAMACHO, A. A. |
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Afiliação: |
Sheila S. S. Nogueira, Departamento de Clínica e Cirurgia Veterinária/Universidade Estadual Paulista - Unesp; Marlos G. Sousa, Departamento de Medicina Veterinária/Universidade Federal do Paraná - UFPR; Fabio N. Gava, Departamento de Clínica e Cirurgia Veterinária/Universidade Estadual Paulista - Unesp; Fernando A. Rosa, Departamento de Clínica e Cirurgia Veterinária/Universidade Estadual Paulista - Unesp; Guilherme D. Melo, Departamento de Clínica/Cirurgia e Reprodução Animal/Unesp; Gustavo Dittrich, Departamento de Medicina Veterinária/Universidade Federal do Paraná - UFPR; Gisele F. Machado, Departamento de Clínica/Cirurgia e Reprodução Animal/Unesp; Aparecido A. Camacho, Departamento de Clínica e Cirurgia Veterinária/Universidade Estadual Paulista - Unesp. |
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Título: |
Matrix metalloproteinases 2 and 9 in rabbits with doxorubicin-induced cardiomyopathy. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 38, n. 2, p. 320-327, fevereiro 2018 |
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Idioma: |
Inglês |
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Notas: |
Título em português: Metaloproteinases de matriz 2 e 9 em coelhos com cardiomiopatia induzida pela doxorrubicina. |
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Conteúdo: |
Some studies have shown the role played by matrix metalloproteinases and their inhibitors in doxorubicin cardiotoxicity. In this study, we sought to investigate how plasma and myocardial MMP 2 and 9 perform in rabbits with doxorubicin-induced cardiomyopathy, searching for a correlation between the activity of these collagenases and cardiac remodeling. Cardiomyopathy was induced by doxorubicin given intravenously twice a week for six consecutive weeks. Plasma MMP activity and the echocardiogram were assessed at baseline, and at 15 and 45 days after first injection of doxorubicin. The myocardial activity of these enzymes was solely evaluated in nine rabbits at 45 days, and results were compared with nine healthy controls. We only identified the full-length forms of both MMP 2 and 9 throughout the study. The plasma pro-MMP 2 reduced along the deterioration of cardiac function, while the pro-MMP 9 increased significantly at T45 as compared to baseline and T15. A negative significant correlation was found to exist between the plasma activity of pro-MMP 2 and mitral E-to-mitral septal annular early diastolic velocity ratio, which is an estimate of mean left atrial pressure and congestion. Only pro-MMP 2 was found in myocardial samples,and mean activity of such enzyme was statistically lower than that recorded for healthy controls. Although no active form was documented for either collagenase, the duration of the treatment with doxorubicin played a role in the alteration of plasma pro-forms activity. However, these changes could not be associated with most echocardiographic parameters that are supportive of cardiac remodeling. MenosSome studies have shown the role played by matrix metalloproteinases and their inhibitors in doxorubicin cardiotoxicity. In this study, we sought to investigate how plasma and myocardial MMP 2 and 9 perform in rabbits with doxorubicin-induced cardiomyopathy, searching for a correlation between the activity of these collagenases and cardiac remodeling. Cardiomyopathy was induced by doxorubicin given intravenously twice a week for six consecutive weeks. Plasma MMP activity and the echocardiogram were assessed at baseline, and at 15 and 45 days after first injection of doxorubicin. The myocardial activity of these enzymes was solely evaluated in nine rabbits at 45 days, and results were compared with nine healthy controls. We only identified the full-length forms of both MMP 2 and 9 throughout the study. The plasma pro-MMP 2 reduced along the deterioration of cardiac function, while the pro-MMP 9 increased significantly at T45 as compared to baseline and T15. A negative significant correlation was found to exist between the plasma activity of pro-MMP 2 and mitral E-to-mitral septal annular early diastolic velocity ratio, which is an estimate of mean left atrial pressure and congestion. Only pro-MMP 2 was found in myocardial samples,and mean activity of such enzyme was statistically lower than that recorded for healthy controls. Although no active form was documented for either collagenase, the duration of the treatment with doxorubicin played a role in the alteration of plasma ... Mostrar Tudo |
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Palavras-Chave: |
Cardiomiopatia; Doxorrubicina; Echocardiogram; Ecocardio; MetaloproteinaseS; Zimografia; Zymography. |
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Thesagro: |
Atividade Enzimática; Cardiopatia; Coelho. |
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Thesaurus Nal: |
Cardiomyopathy; Collagenase; Doxorubicin; Enzyme activity; Heart diseases; Metalloproteinases; Rabbits. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/176152/1/Matrix-metalloproteinases-2-and-9-in-rabbits.pdf
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Marc: |
LEADER 02913naa a2200421 a 4500
001 2091049
005 2018-04-30
008 2018 bl uuuu u00u1 u #d
100 1 $aNOGUEIRA, S. S. S.
245 $aMatrix metalloproteinases 2 and 9 in rabbits with doxorubicin-induced cardiomyopathy.$h[electronic resource]
260 $c2018
500 $aTítulo em português: Metaloproteinases de matriz 2 e 9 em coelhos com cardiomiopatia induzida pela doxorrubicina.
520 $aSome studies have shown the role played by matrix metalloproteinases and their inhibitors in doxorubicin cardiotoxicity. In this study, we sought to investigate how plasma and myocardial MMP 2 and 9 perform in rabbits with doxorubicin-induced cardiomyopathy, searching for a correlation between the activity of these collagenases and cardiac remodeling. Cardiomyopathy was induced by doxorubicin given intravenously twice a week for six consecutive weeks. Plasma MMP activity and the echocardiogram were assessed at baseline, and at 15 and 45 days after first injection of doxorubicin. The myocardial activity of these enzymes was solely evaluated in nine rabbits at 45 days, and results were compared with nine healthy controls. We only identified the full-length forms of both MMP 2 and 9 throughout the study. The plasma pro-MMP 2 reduced along the deterioration of cardiac function, while the pro-MMP 9 increased significantly at T45 as compared to baseline and T15. A negative significant correlation was found to exist between the plasma activity of pro-MMP 2 and mitral E-to-mitral septal annular early diastolic velocity ratio, which is an estimate of mean left atrial pressure and congestion. Only pro-MMP 2 was found in myocardial samples,and mean activity of such enzyme was statistically lower than that recorded for healthy controls. Although no active form was documented for either collagenase, the duration of the treatment with doxorubicin played a role in the alteration of plasma pro-forms activity. However, these changes could not be associated with most echocardiographic parameters that are supportive of cardiac remodeling.
650 $aCardiomyopathy
650 $aCollagenase
650 $aDoxorubicin
650 $aEnzyme activity
650 $aHeart diseases
650 $aMetalloproteinases
650 $aRabbits
650 $aAtividade Enzimática
650 $aCardiopatia
650 $aCoelho
653 $aCardiomiopatia
653 $aDoxorrubicina
653 $aEchocardiogram
653 $aEcocardio
653 $aMetaloproteinaseS
653 $aZimografia
653 $aZymography
700 1 $aSOUSA, M. G.
700 1 $aGAVA, F. N.
700 1 $aROSA, F. A.
700 1 $aMELO, G. D.
700 1 $aDITTRICH, G.
700 1 $aMACHADO, G. F.
700 1 $aCAMACHO, A. A.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 38, n. 2, p. 320-327, fevereiro 2018
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Embrapa Unidades Centrais (AI-SEDE) |
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| Registros recuperados : 3 | |
| 1. |  | SOUSA, M. G.; LIMA, A. B. G.; ARAÚJO, C. R. A.; SILVA, V. B. C.; RAMOS, A. T.; MACHADO, G. F.; MELO, G. D.; CARARETO, R. Blood pressure and renal injury in dogs with visceral leishmaniasis. Pesquisa Veterinária Brasileira, Brasília, DF, v. 39, n. 9, p. 857-863, set. 2016.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 2. | | DUARTE, R. P.; ROCHA, P. R. D. A.; NAKAMURA, A. A.; CIPRIANO, R. S.; VIOL, M. A.; MELO, G. D.; MEIRELES, M. V.; MACHADO, G. F. Detection of natural occurrence of Tritrichomonas foetus in cats in Araçatuba, São Paulo, Brazil. Pesquisa Veterinária Brasileira, Rio de Janeiro, V. 3, n. 2, p. 309-314, fevereiro 2018. Título em português: Detecção da ocorrência natural de Tritrichomonas foetus em gatos em Araçatuba, São Paulo.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 3. | | NOGUEIRA, S. S. S.; SOUSA, M. G.; GAVA, F. N.; ROSA, F. A.; MELO, G. D.; DITTRICH, G.; MACHADO, G. F.; CAMACHO, A. A. Matrix metalloproteinases 2 and 9 in rabbits with doxorubicin-induced cardiomyopathy. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 38, n. 2, p. 320-327, fevereiro 2018 Título em português: Metaloproteinases de matriz 2 e 9 em coelhos com cardiomiopatia induzida pela doxorrubicina.| Biblioteca(s): Embrapa Unidades Centrais. |
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| Registros recuperados : 3 | |
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