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Registro Completo |
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
27/06/2017 |
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Data da última atualização: |
29/12/2017 |
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Autoria: |
ZILIOTTO, L.; LUNA, S. P. L.; A. FILHO, D. A.; RESENDE, L. O.; AUN, A. G.; BRAZ, M. G. |
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Afiliação: |
Liane Ziliotto, Clínica Cirúrgica de Pequenos Animais, Departamento de Medicina Veterinária, Universidade Estadual do Centro-Oeste; Stelio P. L. Luna, Departamento de Cirurgia e Anestesiologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista; Daniel A.A. Filho, Departamento de Anestesiologia, Faculdade de Medicina de Botucatu, Unesp; Ludimila O. Resende, Departamento de Anestesiologia, Faculdade de Medicina de Botucatu, Unesp; Aline G. Aun, Departamento de Anestesiologia, Faculdade de Medicina de Botucatu, Unesp; Mariana G. Braz, Departamento de Anestesiologia, Faculdade de Medicina de Botucatu, Unesp. |
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Título: |
Genotoxicity assessment of fipronil (frontline plus®) in Canis familiaris. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 3, p. 257-260, março 2017 |
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Idioma: |
Inglês |
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Notas: |
Título em português: Avaliação de genotoxicidade do fipronil (frontline plus®) in cães. |
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Conteúdo: |
Fipronil is a pesticide widely used for controlling fleas and ticks in domestic animals, and its short-term exposure can lead to serious effects on animals. However, the possible genotoxic effect of this compound has not been investigated in target animals. Based on the hypothesis that fipronil can induce genotoxicity, this study evaluated the effect of fipronil on DNA damage in peripheral blood cells. For that purpose, ten dogs of both sexes were used in the study. The product (6.7mg/kg) was applied on the dorsal neck region of each animal. Peripheral blood samples were collected immediately prior to application of the product, and at 3, 8 and 24 hours after the application. Samples were processed for comet assay. No statistically significant differences were found among the four time points. The current study suggests for the first time that a single exposure to this pesticide does not induce systemic genotoxic effect in dogs. |
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Palavras-Chave: |
Comet assay; Dano ao DNA; Ensaio cometa; Frontline plus®; Pesticide. |
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Thesagro: |
Cão; Pesticida. |
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Thesaurus Nal: |
DNA damage; Dogs; Fipronil. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/161100/1/Genotoxicity-assessment.pdf
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Marc: |
LEADER 01873naa a2200313 a 4500
001 2071564
005 2017-12-29
008 2017 bl uuuu u00u1 u #d
100 1 $aZILIOTTO, L.
245 $aGenotoxicity assessment of fipronil (frontline plus®) in Canis familiaris.$h[electronic resource]
260 $c2017
500 $aTítulo em português: Avaliação de genotoxicidade do fipronil (frontline plus®) in cães.
520 $aFipronil is a pesticide widely used for controlling fleas and ticks in domestic animals, and its short-term exposure can lead to serious effects on animals. However, the possible genotoxic effect of this compound has not been investigated in target animals. Based on the hypothesis that fipronil can induce genotoxicity, this study evaluated the effect of fipronil on DNA damage in peripheral blood cells. For that purpose, ten dogs of both sexes were used in the study. The product (6.7mg/kg) was applied on the dorsal neck region of each animal. Peripheral blood samples were collected immediately prior to application of the product, and at 3, 8 and 24 hours after the application. Samples were processed for comet assay. No statistically significant differences were found among the four time points. The current study suggests for the first time that a single exposure to this pesticide does not induce systemic genotoxic effect in dogs.
650 $aDNA damage
650 $aDogs
650 $aFipronil
650 $aCão
650 $aPesticida
653 $aComet assay
653 $aDano ao DNA
653 $aEnsaio cometa
653 $aFrontline plus®
653 $aPesticide
700 1 $aLUNA, S. P. L.
700 1 $aA. FILHO, D. A.
700 1 $aRESENDE, L. O.
700 1 $aAUN, A. G.
700 1 $aBRAZ, M. G.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 37, n. 3, p. 257-260, março 2017
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Embrapa Unidades Centrais (AI-SEDE) |
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| 1. |  | ZILIOTTO, L.; LUNA, S. P. L.; A. FILHO, D. A.; RESENDE, L. O.; AUN, A. G.; BRAZ, M. G. Genotoxicity assessment of fipronil (frontline plus®) in Canis familiaris. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 3, p. 257-260, março 2017 Título em português: Avaliação de genotoxicidade do fipronil (frontline plus®) in cães.| Biblioteca(s): Embrapa Unidades Centrais. |
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