Data/hora: 05/06/2024 16:10:06

Biblioteca(s): | Embrapa Agricultura Digital.
Data corrente: | 15/04/2010
Data da última atualização: | 29/09/2016
Autoria: | GOMIDE, J.; MELO-MINARDI, R.; SANTOS, M. A. dos; NESHICH, G.; MEIRA JUNIOR, W.; LOPES, J. C.; SANTORO, M.
Afiliação: | JANAÍNA GOMIDE, UFMG; RAQUEL MELO-MINARDI, UFMG; MARCOS AUGUSTO DOS SANTOS, UFMG; GORAN NESHICH, CNPTIA; WAGNER MEIRA JUNIOR, UFMG; JÚLIO CÉSAR LOPES, UFMG; MARCELO SANTORO, UFMG.
Título: | Using linear algebra for protein structural comparison and classification.
Ano de publicação: | 2009
Fonte/Imprenta: | Genetics and Molecular Biology, v. 32, n. 3, p. 645-651, 2009.
DOI: | http://dx.doi.org/10.1590/S1415-47572009000300032
Idioma: | Inglês
Conteúdo: | In this article, we describe a novel methodology to extract semantic characteristics from protein structures using linear algebra in order to compose structural signature vectors which may be used efficiently to compare and classify protein structures into fold families. These signatures are built from the pattern of hydrophobic intrachain interactions using Singular Value Decomposition (SVD) and Latent Semantic Indexing (LSI) techniques. Considering proteins as documents and contacts as terms, we have built a retrieval system which is able to find conserved contacts in samples of myoglobin fold family and to retrieve these proteins among proteins of varied folds with precision of up to 80%. The classifier is a web tool available at our laboratory website. Users can search for similar chains from a specific PDB, view and compare their contact maps and browse their structures using a JMol plug-in.
Palavras-Chave: | Contact maps; Latent semantic indexing; Linear algebra; Protein classification; Singular value decomposition.
Thesagro: | Biologia molecular.
Thesaurus Nal: | Molecular biology.
Categoria do assunto: | X Pesquisa, Tecnologia e Engenharia
URL: | http://ainfo.cnptia.embrapa.br/digital/bitstream/item/147910/1/AP-UsingLinearAlgebra-Gomide-2009.pdf
Registro original: | Embrapa Agricultura Digital (CNPTIA)

Exemplares:

CNPTIA - (14810-1) - UPC - AP - PP -  -  - 2010.00052 - DES
CNPTIA - (14810-2) - UPC - AP - DD -  -  -  - DIS