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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
18/05/2020 |
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Data da última atualização: |
18/05/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ALVARENGA, M. O. P.; BITTENCOURT, L. O.; MENDES, P. F. S.; RIBEIRA, J. T.; LAMEIRA, O. A.; MONTEIRO, M. C.; BARBOZA, C. A. G.; MARTINS, M. D.; LIMA, R. R. |
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Afiliação: |
María Olimpia Paz Alvarenga, UFPA; Leonardo Oliveira Bittencourt, UFPA; Paulo Fernando Santos Mendes, UFPA; Julia Turra Ribeiro, UFRGS; OSMAR ALVES LAMEIRA, CPATU; Marta Chagas Monteiro, UFPA; Carlos Augusto Galvão Barboza, UFRGS; Manoela Domingues Martins, UFRGS; Rafael Rodrigues Lima, UFPA. |
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Título: |
Safety and effectiveness of Copaiba Oleoresin (C. reticulata Ducke) on inflammation and tissue repair of oral wounds in rats. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
International Journal of Molecular Science, v. 21, n. 10, article 3568, 2020. |
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DOI: |
https://doi.org/10.3390/ijms21103568 |
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Idioma: |
Inglês |
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Conteúdo: |
In traditional communities of the Brazilian Amazon, the copaiba oleoresin (C. reticulata Ducke) is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Our study aimed to evaluate these effects in oral lesions and the safety of the dosage proposed. A punch biopsy wound was induced on the ventral surface of the tongue of forty-five male Wistar rats under anesthesia. Animals were randomly allocated to one of three groups based on the treatment: control, corticoid and copaiba. A daily dose of each treatment and vehicle was administrated by oral gavage for three consecutive days. Sample collections took place on the third, seventh and 15th days post-wounding for clinical and histopathological analyses. Blood was collected on the third and seventh days for kidneys and liver function tests. Semi-quantitative analyses were performed based on scores of inflammation and reepithelization. Tissue collagen deposition was detected by PicroSirius red staining. Copaiba-treated wounds revealed a smaller wound area, decreased of acute inflammatory reaction and enhanced reepithelization. The levels of kidney and liver function tests did not reveal presence of damage post-treatments. Our findings suggest that copaiba oleoresin is a safe and effective alternative therapy for inflammation and tissue repair of oral wounds in this animal model. |
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Thesagro: |
Antiinflamatório; Cicatrização; Copaíba; Oleorresina; Terapia. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/213059/1/ijms-21-03568.pdf
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Marc: |
LEADER 02303naa a2200289 a 4500
001 2122369
005 2020-05-18
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3390/ijms21103568$2DOI
100 1 $aALVARENGA, M. O. P.
245 $aSafety and effectiveness of Copaiba Oleoresin (C. reticulata Ducke) on inflammation and tissue repair of oral wounds in rats.$h[electronic resource]
260 $c2020
520 $aIn traditional communities of the Brazilian Amazon, the copaiba oleoresin (C. reticulata Ducke) is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Our study aimed to evaluate these effects in oral lesions and the safety of the dosage proposed. A punch biopsy wound was induced on the ventral surface of the tongue of forty-five male Wistar rats under anesthesia. Animals were randomly allocated to one of three groups based on the treatment: control, corticoid and copaiba. A daily dose of each treatment and vehicle was administrated by oral gavage for three consecutive days. Sample collections took place on the third, seventh and 15th days post-wounding for clinical and histopathological analyses. Blood was collected on the third and seventh days for kidneys and liver function tests. Semi-quantitative analyses were performed based on scores of inflammation and reepithelization. Tissue collagen deposition was detected by PicroSirius red staining. Copaiba-treated wounds revealed a smaller wound area, decreased of acute inflammatory reaction and enhanced reepithelization. The levels of kidney and liver function tests did not reveal presence of damage post-treatments. Our findings suggest that copaiba oleoresin is a safe and effective alternative therapy for inflammation and tissue repair of oral wounds in this animal model.
650 $aAntiinflamatório
650 $aCicatrização
650 $aCopaíba
650 $aOleorresina
650 $aTerapia
700 1 $aBITTENCOURT, L. O.
700 1 $aMENDES, P. F. S.
700 1 $aRIBEIRA, J. T.
700 1 $aLAMEIRA, O. A.
700 1 $aMONTEIRO, M. C.
700 1 $aBARBOZA, C. A. G.
700 1 $aMARTINS, M. D.
700 1 $aLIMA, R. R.
773 $tInternational Journal of Molecular Science$gv. 21, n. 10, article 3568, 2020.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Uva e Vinho. Para informações adicionais entre em contato com cnpuv.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Uva e Vinho. |
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Data corrente: |
14/01/2008 |
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Data da última atualização: |
13/01/2010 |
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Tipo da produção científica: |
Artigo de Divulgação na Mídia |
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Autoria: |
PROTAS, J. F. da S. |
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Afiliação: |
José Fernando da Silva Protas, Embrapa Uva e Vinho. |
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Título: |
Vitis Brasil: vinícolas da Serra Gaúcha contam com a mais avançada tecnologia de produção, idêntica à utilizada nos principais países vinícolas da Europa. |
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Ano de publicação: |
2007 |
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Fonte/Imprenta: |
In: ANUÁRIO Brasileiro da Uva e do Vinho. Santa Cruz do Sul: Gazeta, 2007. |
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Volume: |
v. 4 |
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Páginas: |
p. 106-111. |
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Idioma: |
Português |
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Palavras-Chave: |
Brasil; Concorrência; Região da Serra Gaúcha. |
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Thesagro: |
Enologia; Mercado; Produção; Qualidade; Uva; Venda; Vinho; Viticultura. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 00793naa a2200265 a 4500
001 1542286
005 2010-01-13
008 2007 bl uuuu u00u1 u #d
100 1 $aPROTAS, J. F. da S.
245 $aVitis Brasil$bvinícolas da Serra Gaúcha contam com a mais avançada tecnologia de produção, idêntica à utilizada nos principais países vinícolas da Europa.
260 $c2007
300 $ap. 106-111. v. 4
490 $vv. 4
650 $aEnologia
650 $aMercado
650 $aProdução
650 $aQualidade
650 $aUva
650 $aVenda
650 $aVinho
650 $aViticultura
653 $aBrasil
653 $aConcorrência
653 $aRegião da Serra Gaúcha
773 $tIn: ANUÁRIO Brasileiro da Uva e do Vinho. Santa Cruz do Sul: Gazeta, 2007.
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Embrapa Uva e Vinho (CNPUV) |
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