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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria Tropical. Para informações adicionais entre em contato com cnpat.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios. |
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Data corrente: |
02/01/2023 |
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Data da última atualização: |
29/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LIMA, L. F. DE; ANDRADE-PINHEIRO, J. C.; FREITAS, M. A.; SILVA, A. I. DA; FONSECA, V. J. A.; SILVA, T. G. DA; SILVA, J. C. P. DA; LIMA, R. H. DE; SALES, D. L.; NEVES, R. P.; BRITO, E. S. de; RIBEIRO, P. R. V.; CANUTO, K. M.; COUTINHO, H. D. M.; SIYADATPANAH, A.; KIM, B.; MORAIS-BRAGA, M. F. B. |
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Afiliação: |
LUCIENE FERREIRA DE LIMA, University Regional of Cariri; JACQUELINE COSMO ANDRADE-PINHEIRO, University Regional of Cariri; MARIA AUDILENE FREITAS, University Federal of Pernambuco; ADRIELY IDALINA DA SILVA, University Federal of Pernambuco; VICTOR JUNO ALENCAR FONSECA, University Regional of Cariri; TAÍS GUSMÃO DA SILVA, University Regional of Cariri; JOSEFA CAROLAINE PEREIRA DA SILVA, University Regional of Cariri; ROSILAINE HONORATO DE LIMA, University Regional of Cariri; DÉBORA LIMA SALES, University Regional of Cariri; REJANE PEREIRA NEVES, University Federal of Pernambuco; EDY SOUSA DE BRITO, CNAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; KIRLEY MARQUES CANUTO, CNPAT; HENRIQUE DOUGLAS MELO COUTINHO, University Regional of Cariri; ABOLGHASEM SIYADATPANAH, Birjand University of Medical Sciences; BONGLEE KIM, Kyung Hee University; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, University Regional of Cariri. |
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Título: |
Anti-Candida properties of Gossypium hirsutum L.: enhancement of fungal growth, biofilm production and antifungal resistance. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Pharmaceutics, v. 14, n. 698, 2022. |
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Páginas: |
18 p. |
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DOI: |
https://doi.org/10.3390/pharmaceutics140406982022 |
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Idioma: |
Inglês |
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Conteúdo: |
(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition and anti-Candida effects of aqueous (AELG) and hydroethanolic (HELG) extracts obtained from the leaves of this plant. (2) Methods: The extracts were chemically characterized by UPLC-QTOF-MS/MS, and their anti-Candida activities were investigated by analyzing cell viability, biofilm production, morphological transition, and enhancement of antifungal resistance. (3) Results: The UPLC-QTOF-MS/MS analysis revealed the presence of twenty-one compounds in both AELG and HELG, highlighting the predominance of flavonoids. The combination of the extracts with fluconazole significantly reduced its IC50 values against Candida albicans INCQS 40006, Candida tropicalis INCQS 40042, and C. tropicalis URM 4262 strains, indicating enhanced antifungal activity. About biofilm production, significant inhibition was observed only for the AELG-treated C. tropicalis URM 4262 strain in comparison with the untreated control. Accordingly, this extract showed more significant inhibitory effects on the morphological transition of the INCQS 40006 and URM 4387 strains of C. albicans (4) Conclusions: Gossypium hirsutum L. presents promising antifungal effects, that may be potentially linked to the combined activity of chemical constituents identified in its extracts. Menos(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition and anti-Candida effects of aqueous (AELG) and hydroethanolic (HELG) extracts obtained from the leaves of this plant. (2) Methods: The extracts were chemically characterized by UPLC-QTOF-MS/MS, and their anti-Candida activities were investigated by analyzing cell viability, biofilm production, morphological transition, and enhancement of antifungal resistance. (3) Results: The UPLC-QTOF-MS/MS analysis revealed the presence of twenty-one compounds in both AELG and HELG, highlighting the predominance of flavonoids. The combination of the extracts with fluconazole significantly reduced its IC50 values against Candida albicans INCQS 40006, Candida tropicalis INCQS 40042, and C. tropicalis URM 4262 strains, indicating enhanced antifungal activity. About biofilm production, significant inhibition was observed only for the AELG-treated C. tropicalis URM 4262 strain in comparison with the untreated control. Accordingly, this extract showed more significant inhibitory effects on the morphological transition of the INCQS 40006 and URM 4387 strains of C. albicans (4) Conclusions: Gossypium hirsutum L. presents promising antifungal effects, that... Mostrar Tudo |
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Palavras-Chave: |
Antimicrobial resistance; Biofilm eradication; Erradicação do biofilme; Resistência antimicrobiana; UPLC-QTOF-MS/MS. |
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Thesagro: |
Gossypium Hirsutum; Malvaceae. |
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Categoria do assunto: |
--
W Química e Física |
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Marc: |
LEADER 02880naa a2200421 a 4500
001 2153889
005 2024-02-29
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3390/pharmaceutics140406982022$2DOI
100 1 $aLIMA, L. F. DE
245 $aAnti-Candida properties of Gossypium hirsutum L.$benhancement of fungal growth, biofilm production and antifungal resistance.$h[electronic resource]
260 $c2022
300 $a18 p.
520 $a(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition and anti-Candida effects of aqueous (AELG) and hydroethanolic (HELG) extracts obtained from the leaves of this plant. (2) Methods: The extracts were chemically characterized by UPLC-QTOF-MS/MS, and their anti-Candida activities were investigated by analyzing cell viability, biofilm production, morphological transition, and enhancement of antifungal resistance. (3) Results: The UPLC-QTOF-MS/MS analysis revealed the presence of twenty-one compounds in both AELG and HELG, highlighting the predominance of flavonoids. The combination of the extracts with fluconazole significantly reduced its IC50 values against Candida albicans INCQS 40006, Candida tropicalis INCQS 40042, and C. tropicalis URM 4262 strains, indicating enhanced antifungal activity. About biofilm production, significant inhibition was observed only for the AELG-treated C. tropicalis URM 4262 strain in comparison with the untreated control. Accordingly, this extract showed more significant inhibitory effects on the morphological transition of the INCQS 40006 and URM 4387 strains of C. albicans (4) Conclusions: Gossypium hirsutum L. presents promising antifungal effects, that may be potentially linked to the combined activity of chemical constituents identified in its extracts.
650 $aGossypium Hirsutum
650 $aMalvaceae
653 $aAntimicrobial resistance
653 $aBiofilm eradication
653 $aErradicação do biofilme
653 $aResistência antimicrobiana
653 $aUPLC-QTOF-MS/MS
700 1 $aANDRADE-PINHEIRO, J. C.
700 1 $aFREITAS, M. A.
700 1 $aSILVA, A. I. DA
700 1 $aFONSECA, V. J. A.
700 1 $aSILVA, T. G. DA
700 1 $aSILVA, J. C. P. DA
700 1 $aLIMA, R. H. DE
700 1 $aSALES, D. L.
700 1 $aNEVES, R. P.
700 1 $aBRITO, E. S. de
700 1 $aRIBEIRO, P. R. V.
700 1 $aCANUTO, K. M.
700 1 $aCOUTINHO, H. D. M.
700 1 $aSIYADATPANAH, A.
700 1 $aKIM, B.
700 1 $aMORAIS-BRAGA, M. F. B.
773 $tPharmaceutics$gv. 14, n. 698, 2022.
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Registro original: |
Embrapa Alimentos e Territórios (CNAT) |
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Biblioteca |
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| Registros recuperados : 39 | |
| 9. |  | LIMA, L. F.; ROMEIRO, A. R.; ABREU, L. S. de; MANGABEIRA, J. A. de C. Construção de uma tipologia para a produção orgânica no Brasil. In: CONGRESSO DA SOCIEDADE BRASILEIRA DE ECONOMIA, ADMINISTRAÇÃO E SOCIOLOGIA RURAL, 59.; ENCONTRO BRASILEIRO DE PESQUISADORES EM COOPERATIVISMO, 6., 2021, Brasília, DF. Anais... Brasília, DF: UnB, 2021. 19 p. Sober 2021, EBPC 2021. Evento online. 20 p. 20 p.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Meio Ambiente; Embrapa Territorial. |
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| 10. | | SIGNOR, D.; MORAES, S. A. de; OLIVEIRA, R. G.; DEON, M. D.; LIMA, L. F. Gliricidia sepium seedlings development due to biochar and manure application. In: WORLD CONGRESS ON INTEGRATED CROP-LIVESTOCK-FOREST SYSTEMS; INTERNATIONAL SYMPOSIUM ON INTEGRATED CROP-LIVESTOCK SYSTEMS, 3., 2015, Brasília, DF. Towards sustainable intensification: proceedings. Brasília, DF: Embrapa, 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Semiárido. |
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| 15. | | ARAÚJO, C. S. de; LIMA, L. F.; SALES, F. de; CARNEIRO, J. C.; LUNZ, A. M. P. Biometria de clones de cafeeiro (Coffea canephora) no município de Rio Branco-AC. In: CONGRESSO REGIONAL DE PESQUISA DO ESTADO DO ACRE, 2.; SEMINÁRIO DE INICIAÇÃO CIENTÍFICA DA UFAC, 25., 2016, Rio Branco/Cruzeiro do Sul. Inovação: sustentabilidade e desenvolvimento regional: anais. Rio Branco, AC: Edufac, 2016. p. 63.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Acre. |
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| 16. | | LIMA, L. F.; TORTURELLA, R. D.; SARTORI, R.; SILVA, T. A. S. N.; CAMPOS, G. M.; NEVES, J. P. Coleta de sêmen em ovinos em estação ou decúbito lateral utilizando-se diferentes eletroejaculadores. In: CONGRESSO BRASILEIRO DE REPRODUÇÃO ANIMAL, 17., 2007, Curitiba. Anais... Belo Horizonte: CBRA, 2007. p. 216.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 17. | | FORERO-PEÑUELA, L. Y.; DESCHAMPS, C.; DE ASSIS, A. L. A.; DE LIMA, L. F.; BIZZO, H.; ROSA, G. M. Caracterización química del aceite esencial de Lippia alba quimiotipo linalol, en el municipio de Pinhais, Paraná, Brasil. In: SIMPÓSIO IBEROAMERICANO DE PLANTAS MEDICINAIS, 5., 2010, Itajaí. Posters... Itajaí: Univali, 2010.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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| 18. | | NEVES, J. P.; LIMA, L. F.; MOURA, P.; PASSOS, P. I. B.; LEAL, D. R.; RUMPF, R. Influência de sistemas de refrigeração sobre a qualidade do sêmen ovino criopreservado em palhetas. Acta Scientiae Veterinariae, v. 36, supl. 2, p. S554, 2008. Edição dos resumos da 22. Reunião Anual da Sociedade Brasileira de Tecnologia de Embriões, Guarujá, SP, 2008.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 20. | | RODRIGUES, M. C. S. F.; FREIRE FILHO, F. R.; SILVA, R. C. da; LIMA, L. F. de. Seleção de genótipos de feijão-de-metro (feijão-verde) [Vigna unguiculata (L.) Walp], cv-gr. Sesquipedalis para composição do ensaio de valor de cultivo e uso (VCU). In: SEMINÁRIO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA AMAZÔNIA ORIENTAL, 21., 2017, Belém, PA. Anais. Belém, PA: Embrapa Amazônia Oriental, 2017.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| Registros recuperados : 39 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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