|
|
Registro Completo |
Biblioteca(s): |
Embrapa Cerrados. |
Data corrente: |
20/02/2006 |
Data da última atualização: |
07/07/2017 |
Autoria: |
BARBOSA, V.; MAGNABOSCO, C. de U.; FARIA, C. U. de; CUNHA, F. A. R. da; MANICARDI, F.; BEZERRA, L. A. F.; LÔBO, R. B.; SAINZ, R. D. |
Título: |
Inferência bayesiana no estudo genético quantitativo de características de carcaça em novilhos da raça nelore utilizando a técnica de ultrasonografia. |
Ano de publicação: |
2005 |
Fonte/Imprenta: |
Planaltina, DF: Embrapa Cerrados, 2005. |
Descrição Física: |
1 folder. |
Idioma: |
Português |
Thesagro: |
Amostragem; Gado de Corte; Gado Nelore; Genética Animal; Melhoramento Genético Animal. |
Thesaurus Nal: |
animal breeding; beef cattle; genetics; sampling. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/CPAC-2009/26789/1/p2005_26.pdf
|
Marc: |
LEADER 00905nam a2200301 a 4500 001 1568950 005 2017-07-07 008 2005 bl uuuu u0uu1 u #d 100 1 $aBARBOSA, V. 245 $aInferência bayesiana no estudo genético quantitativo de características de carcaça em novilhos da raça nelore utilizando a técnica de ultrasonografia. 260 $aPlanaltina, DF: Embrapa Cerrados$c2005 300 $c1 folder. 650 $aanimal breeding 650 $abeef cattle 650 $agenetics 650 $asampling 650 $aAmostragem 650 $aGado de Corte 650 $aGado Nelore 650 $aGenética Animal 650 $aMelhoramento Genético Animal 700 1 $aMAGNABOSCO, C. de U. 700 1 $aFARIA, C. U. de 700 1 $aCUNHA, F. A. R. da 700 1 $aMANICARDI, F. 700 1 $aBEZERRA, L. A. F. 700 1 $aLÔBO, R. B. 700 1 $aSAINZ, R. D.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Cerrados (CPAC) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
Registro Completo
Biblioteca(s): |
Embrapa Pantanal. |
Data corrente: |
19/07/2023 |
Data da última atualização: |
19/07/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
NOGUEIRA, E.; TIRPÁK, F.; HAMILTON, L.; ZIGO, M.; KERNS, K.; SUTOVSKY, M.; KIM, J.; VOLKMANN, D.; JOVINE, L.; TAYLOR, J. F.; SCHNABEL, R. D.; SUTOVSKY, P. |
Afiliação: |
ERIKLIS NOGUEIRA, CPAP; FILIP TIRPÁK, Slovak University of Agriculture; LAUREN HAMILTON, UNIVERISTY OF MISSOURI; MICHAL ZIGO, UNIVERSITY OF MISSOURI; KARL KERNS, UNIVERSITY OF MISSOURI; MIRIAM SUTOVSKY, UNIVERSITY OF MISSOURI; JAEWOO KIM, UNIVERSITY OF MISSOURI; DIETRICH VOLKMANN, UNIVERSITY OF MISSOURI; LUCA JOVINE, KAROLINSKA INSTITUTET; JEREMY F. TAYLOR, UNIVERSITY OF MISSOURI; ROBERT D. SCHNABEL, UNIVERSITY OF MISSOURI; PETER SUTOVSKY, UNIVERSITY OF MISSOURI. |
Título: |
A Non-synonymous point mutation in a WD-40 domain repeat of EML5 leads to decreased bovine sperm quality and fertility. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Frontiers in Cell and Developmental Biology, v. 10, 872740, Apr. 2022. |
ISSN: |
2296-634X |
DOI: |
https://doi.org/10.3389/fcell.2022.872740 |
Idioma: |
Inglês |
Conteúdo: |
This study is part of a concerted effort to identify and phenotype rare, deleterious mutations that adversely affect sperm quality, or convey high developmental and fertility potential to embryos and ensuing progeny. A rare, homozygous mutation in EML5 (EML5R1654W), which encodes a microtubule-associated protein with high expression in testis and brain was identified in an Angus bull used extensively in artificial insemination (AI) for its outstanding progeny production traits. The bull?s fertility was low in cross-breeding timed AI (TAI) (Pregnancy/TAI = 25.2%; n = 222) and, in general, AI breeding to Nellore cows (41%; n = 822). A search of the 1,000 Bull Genomes Run9 database revealed an additional 74 heterozygous animals and 8 homozygous animals harboring this exact mutation across several different breeds (0.7% frequency within the 6,191 sequenced animals). Phenotypically, spermatozoa from the homozygous Angus bull displayed prominent piriform and tapered heads, and outwardly protruding knobbed acrosomes. Additionally, an increased retention of EML5 was also observed in the sperm head of both homozygous and heterozygous Angus bulls compared to wild-type animals. This non-synonymous point mutation is located within a WD40 signaling domain repeat of EML5 and is predicted to be detrimental to overall protein function by genomic single nucleotide polymorphism (SNP) analysis and protein modeling. Future work will examine how this rare mutation affects field AI fertility and will characterize the role of EML5 in spermatogenesis. MenosThis study is part of a concerted effort to identify and phenotype rare, deleterious mutations that adversely affect sperm quality, or convey high developmental and fertility potential to embryos and ensuing progeny. A rare, homozygous mutation in EML5 (EML5R1654W), which encodes a microtubule-associated protein with high expression in testis and brain was identified in an Angus bull used extensively in artificial insemination (AI) for its outstanding progeny production traits. The bull?s fertility was low in cross-breeding timed AI (TAI) (Pregnancy/TAI = 25.2%; n = 222) and, in general, AI breeding to Nellore cows (41%; n = 822). A search of the 1,000 Bull Genomes Run9 database revealed an additional 74 heterozygous animals and 8 homozygous animals harboring this exact mutation across several different breeds (0.7% frequency within the 6,191 sequenced animals). Phenotypically, spermatozoa from the homozygous Angus bull displayed prominent piriform and tapered heads, and outwardly protruding knobbed acrosomes. Additionally, an increased retention of EML5 was also observed in the sperm head of both homozygous and heterozygous Angus bulls compared to wild-type animals. This non-synonymous point mutation is located within a WD40 signaling domain repeat of EML5 and is predicted to be detrimental to overall protein function by genomic single nucleotide polymorphism (SNP) analysis and protein modeling. Future work will examine how this rare mutation affects field AI fertility and ... Mostrar Tudo |
Thesagro: |
Espermatozóide; Fertilidade Animal. |
Thesaurus NAL: |
Acrosome; Animal fertility; Biogenesis; Fertilization (reproduction); Spermatozoa; Spermiogenesis. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1155065/1/fcell-2022.pdf
|
Marc: |
LEADER 02641naa a2200373 a 4500 001 2155065 005 2023-07-19 008 2022 bl uuuu u00u1 u #d 022 $a2296-634X 024 7 $ahttps://doi.org/10.3389/fcell.2022.872740$2DOI 100 1 $aNOGUEIRA, E. 245 $aA Non-synonymous point mutation in a WD-40 domain repeat of EML5 leads to decreased bovine sperm quality and fertility.$h[electronic resource] 260 $c2022 520 $aThis study is part of a concerted effort to identify and phenotype rare, deleterious mutations that adversely affect sperm quality, or convey high developmental and fertility potential to embryos and ensuing progeny. A rare, homozygous mutation in EML5 (EML5R1654W), which encodes a microtubule-associated protein with high expression in testis and brain was identified in an Angus bull used extensively in artificial insemination (AI) for its outstanding progeny production traits. The bull?s fertility was low in cross-breeding timed AI (TAI) (Pregnancy/TAI = 25.2%; n = 222) and, in general, AI breeding to Nellore cows (41%; n = 822). A search of the 1,000 Bull Genomes Run9 database revealed an additional 74 heterozygous animals and 8 homozygous animals harboring this exact mutation across several different breeds (0.7% frequency within the 6,191 sequenced animals). Phenotypically, spermatozoa from the homozygous Angus bull displayed prominent piriform and tapered heads, and outwardly protruding knobbed acrosomes. Additionally, an increased retention of EML5 was also observed in the sperm head of both homozygous and heterozygous Angus bulls compared to wild-type animals. This non-synonymous point mutation is located within a WD40 signaling domain repeat of EML5 and is predicted to be detrimental to overall protein function by genomic single nucleotide polymorphism (SNP) analysis and protein modeling. Future work will examine how this rare mutation affects field AI fertility and will characterize the role of EML5 in spermatogenesis. 650 $aAcrosome 650 $aAnimal fertility 650 $aBiogenesis 650 $aFertilization (reproduction) 650 $aSpermatozoa 650 $aSpermiogenesis 650 $aEspermatozóide 650 $aFertilidade Animal 700 1 $aTIRPÁK, F. 700 1 $aHAMILTON, L. 700 1 $aZIGO, M. 700 1 $aKERNS, K. 700 1 $aSUTOVSKY, M. 700 1 $aKIM, J. 700 1 $aVOLKMANN, D. 700 1 $aJOVINE, L. 700 1 $aTAYLOR, J. F. 700 1 $aSCHNABEL, R. D. 700 1 $aSUTOVSKY, P. 773 $tFrontiers in Cell and Developmental Biology$gv. 10, 872740, Apr. 2022.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Pantanal (CPAP) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
Nenhum registro encontrado para a expressão de busca informada. |
|
|