| |
|
|
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Instrumentação. |
|
Data corrente: |
16/12/2021 |
|
Data da última atualização: |
16/12/2021 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
BRUNETTO, M. A.; RUBERTI, B.; HALFEN, D. P.; CARAGELASCO, D. S.; VENDRAMINI, T. H. A.; PEDRINELLI, V.; MACEDO, H. T.; JEREMIAS, J. T.; PONTIERI, C. F. F.; OCAMPOS, F. M. M.; COLNAGO, L. A.; KOGIKA, M. M. |
|
Afiliação: |
MARCIO ANTONIO BRUNETTO, USP; BRUNA RUBERTI, USP; DORIS PEREIRA HALFEN, USP; DOUGLAS SEGALLA CARAGELASCO, USP; THIAGO HENRIQUE ANNIBALE VENDRAMINI, USP; VIVIAN PEDRINELLI, USP; HENRIQUE TOBARO MACEDO, USP; JULIANA TOLOI JEREMIAS, GRANDFOOD INDUSTRIA E COMERCIO; CRISTIANA FONSECA FERREIRA PONTIERI, GRANDFOOD INDUSTRIA E COMERCIO; FERNANDA MARIA MARINS OCAMPOS, CNPDIA; LUIZ ALBERTO COLNAGO, CNPDIA; MARCIA MERY KOGIKA, USP. |
|
Título: |
Healthy and Chronic Kidney Disease (CKD) dogs have differences in serum metabolomics and renal diet may have slowed disease progression. |
|
Ano de publicação: |
2021 |
|
Fonte/Imprenta: |
Metabolites, v. 11, n. 782, p. 1-13, 2021. |
|
DOI: |
10.3390/metabo11110782 |
|
Idioma: |
Inglês |
|
Conteúdo: |
ABSTRACT: Chronic kidney disease (CKD) is highly prevalent in dogs, and metabolomics investigation has been recently introduced for a better understanding of the role of diet in CKD. This study aimed to compare the serum metabolomic profile of healthy dogs (CG) and dogs with CKD (CKD-T0 and CKD-T6) to evaluate whether the diet would affect metabolites. Six dogs (5 females; 1 male; 7.47 ± 2.31 years old) with CKD stage 3 or 4 (IRIS) were included. CG consisted of 10 healthy female dogs (5.89 ± 2.57 years old) fed a maintenance diet. Serum metabolites were analyzed by 1H nuclear magnetic resonance (1H NMR) spectra. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were performed to assess differences in metabolomic profiles between groups and before (CKD-T0) and after renal diet (CKD-T6). Data analysis was performed on SIMCA-P software. Dogs with CKD showed an altered metabolic profile with increased urea, creatinine, creatine, citrate, and lipids. Lactate, branched-chain amino acids (BCAAs), and glutamine were decreased in the CKD group. However, after 6 months of diet, the metabolite profiles of CKD-T0 and CKD-T6 were similar. Metabolomics profile may be useful to evaluate and recognize metabolic dysfunction and progression of CKD, and the diet may have helped maintain and retard the progression of CKD. |
|
Palavras-Chave: |
Metabolic profile; Renal dogs; Survival; Uremic toxins. |
|
Thesaurus Nal: |
Animal nutrition. |
|
Categoria do assunto: |
-- |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/229293/1/2021-metabolites-kidney.pdf
|
|
Marc: |
LEADER 02341naa a2200325 a 4500
001 2137959
005 2021-12-16
008 2021 bl uuuu u00u1 u #d
024 7 $a10.3390/metabo11110782$2DOI
100 1 $aBRUNETTO, M. A.
245 $aHealthy and Chronic Kidney Disease (CKD) dogs have differences in serum metabolomics and renal diet may have slowed disease progression.$h[electronic resource]
260 $c2021
520 $aABSTRACT: Chronic kidney disease (CKD) is highly prevalent in dogs, and metabolomics investigation has been recently introduced for a better understanding of the role of diet in CKD. This study aimed to compare the serum metabolomic profile of healthy dogs (CG) and dogs with CKD (CKD-T0 and CKD-T6) to evaluate whether the diet would affect metabolites. Six dogs (5 females; 1 male; 7.47 ± 2.31 years old) with CKD stage 3 or 4 (IRIS) were included. CG consisted of 10 healthy female dogs (5.89 ± 2.57 years old) fed a maintenance diet. Serum metabolites were analyzed by 1H nuclear magnetic resonance (1H NMR) spectra. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were performed to assess differences in metabolomic profiles between groups and before (CKD-T0) and after renal diet (CKD-T6). Data analysis was performed on SIMCA-P software. Dogs with CKD showed an altered metabolic profile with increased urea, creatinine, creatine, citrate, and lipids. Lactate, branched-chain amino acids (BCAAs), and glutamine were decreased in the CKD group. However, after 6 months of diet, the metabolite profiles of CKD-T0 and CKD-T6 were similar. Metabolomics profile may be useful to evaluate and recognize metabolic dysfunction and progression of CKD, and the diet may have helped maintain and retard the progression of CKD.
650 $aAnimal nutrition
653 $aMetabolic profile
653 $aRenal dogs
653 $aSurvival
653 $aUremic toxins
700 1 $aRUBERTI, B.
700 1 $aHALFEN, D. P.
700 1 $aCARAGELASCO, D. S.
700 1 $aVENDRAMINI, T. H. A.
700 1 $aPEDRINELLI, V.
700 1 $aMACEDO, H. T.
700 1 $aJEREMIAS, J. T.
700 1 $aPONTIERI, C. F. F.
700 1 $aOCAMPOS, F. M. M.
700 1 $aCOLNAGO, L. A.
700 1 $aKOGIKA, M. M.
773 $tMetabolites$gv. 11, n. 782, p. 1-13, 2021.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Instrumentação (CNPDIA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
Registro Completo
|
Biblioteca(s): |
Embrapa Algodão. |
|
Data corrente: |
29/01/2009 |
|
Data da última atualização: |
29/01/2009 |
|
Tipo da produção científica: |
Artigo em Anais de Congresso / Nota Técnica |
|
Autoria: |
FREIRE, M. A. de O.; SAMPAIO, L. R.; ALBUQUERQUE, W. G. de; OLIVEIRA, M. I. P. de; SEVERINO, L. S.; BELTRÃO, N. E. de M. |
|
Afiliação: |
Maria Aline de Oliveira Freire, UVA; Ligia RodriguesSampaio, UFCG; Walker Gomes de Albuquerque; Maria Isaura Pereira de Oliveira; Liv Soares Severino, Embrapa Algodão; Napoleão Esberard de Macêdo Beltrão, Embrapa Algodão. |
|
Título: |
Avaliação do efeito do resíduo de sete espécies de leguminosas, sobre a emergência e crescimento inicial da mamoneira. |
|
Ano de publicação: |
2008 |
|
Fonte/Imprenta: |
In: CONGRESSO BRASILEIRO DE MAMONA, 3., 2008, Salvador. Energia e ricinoquímica: anais. Salvador: SEAGRI: Embrapa Algodão, 2008. |
|
Descrição Física: |
1 CD-ROM |
|
Idioma: |
Português |
|
Notas: |
Produção Científica. Novembro2008. |
|
Thesagro: |
Adubação Verde; Germinação; Ricinus Communis. |
|
Categoria do assunto: |
-- |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/CNPA-2009-09/21971/1/MC-01.pdf
|
|
Marc: |
LEADER 00795nam a2200217 a 4500
001 1277948
005 2009-01-29
008 2008 bl uuuu u00u1 u #d
100 1 $aFREIRE, M. A. de O.
245 $aAvaliação do efeito do resíduo de sete espécies de leguminosas, sobre a emergência e crescimento inicial da mamoneira.
260 $aIn: CONGRESSO BRASILEIRO DE MAMONA, 3., 2008, Salvador. Energia e ricinoquímica: anais. Salvador: SEAGRI: Embrapa Algodão$c2008
300 $c1 CD-ROM
500 $aProdução Científica. Novembro2008.
650 $aAdubação Verde
650 $aGerminação
650 $aRicinus Communis
700 1 $aSAMPAIO, L. R.
700 1 $aALBUQUERQUE, W. G. de
700 1 $aOLIVEIRA, M. I. P. de
700 1 $aSEVERINO, L. S.
700 1 $aBELTRÃO, N. E. de M.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Algodão (CNPA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Expressão de busca inválida. Verifique!!! |
|
|
