Data/hora: 07/06/2024 12:20:10

Biblioteca(s): | Embrapa Pantanal.
Data corrente: | 20/08/2003
Data da última atualização: | 27/03/2017
Autoria: | FOURNIER, D.; BRIDE, J. M.; HOFFMANN, F.; KARCH, F.
Afiliação: | Centre de Recherche d'Antibes, Laboratoire de Biologie des Invertebres, Antibes, France; Department of Zoology and Animal Bioloogy, University of Geneva, Cheone-Bougeries, Geneva, Swirtzerland.
Título: | Acetylcholinesterase two types of modifications confer resistance to insecticide.
Ano de publicação: | 1992
Fonte/Imprenta: | Journal of Biological Chemistry, v.267, n.20, p.14270-14274, 1992.
Idioma: | Inglês
Conteúdo: | Quantitative and qualitative changes in acetylcholinesterase confer resistance to insecticides. We have constructed several Drosophila melanogaster strains producing various amounts of enzyme by P-mediated transformation. Toxicological analysis of these strains demonstrates that resistance to organophosphorus insecticides is correlated with the amount of acetylcholinesterase in the central nervous system. Resistance may also be qualitatively determined. Comparison of the Drosophila acetylcholinesterase gene between a resistant strain caught in the wild and a wild type susceptible strain only revealed one nucleotide transition resulting in the replacement of a phenylalanine by a tyrosine. Flies mutant for acetylcholinesterase and rescued with a minigene mutagenised for this same transition produced an altered enzyme which renders flies resistant to pesticides.
Palavras-Chave: | Fly; Insectecide; Insetecida; Resistance.
Thesagro: | Drosophila Melanogaster; Mosca; Resistência.
Categoria do assunto: | --
Registro original: | Embrapa Pantanal (CPAP)
Exemplares: | CPAP - (53573-1) - ADC - SP - PP - SP16495 -  - 16495 - DIS