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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sul. |
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Data corrente: |
07/12/2020 |
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Data da última atualização: |
07/12/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
JUNQUEIRA, V. S.; LOPES, P. S.; LOURENCO, D.; SILVA, F. F. e; CARDOSO, F. F. |
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Afiliação: |
Vinícius Silva Junqueira, UFV; Paulo Sávio Lopes, UFV; Daniela Lourenco, University of Georgia; Fabyano Fonseca e Silva, UFV; FERNANDO FLORES CARDOSO, CPPSUL. |
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Título: |
Applying the metafounders approach for genomic evaluation in a multibreed beef cattle population. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Frontiers in Genetics, v. 11, 556399, Dec. 2020. |
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Idioma: |
Inglês |
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Notas: |
Article 556399. |
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Conteúdo: |
Pedigree information is incomplete by nature and commonly not well-established because many of the genetic ties are not known a priori or can be wrong. The genomic era brought new opportunities to assess relationships between individuals. However, when pedigree and genomic information are used simultaneously, which is the case of single-step genomic BLUP (ssGBLUP), defining the genetic base is still a challenge. One alternative to overcome this challenge is to use metafounders, which are pseudo-individuals that describe the genetic relationship between the base population individuals. The purpose of this study was to evaluate the impact of metafounders on the estimation of breeding values for tick resistance under ssGBLUP for a multibreed population composed by Hereford, Braford, and Zebu animals. Three different scenarios were studied: pedigree-based model (BLUP), ssGBLUP, and ssGBLUP with metafounders (ssGBLUPm). In ssGBLUPm, a total of four different metafounders based on breed of origin (i.e., Hereford, Braford, Zebu, and unknown) were included for the animals with missing parents. The relationship coefficient between metafounders was in average 0.54 (ranging from 0.34 to 0.96) suggesting an overlap between ancestor populations. The estimates of metafounder relationships indicate that Hereford and Zebu breeds have a possible common ancestral relationship. Inbreeding coefficients calculated following the metafounder approach had less negative values, suggesting that ancestral populations were large enough and that gametes inherited from the historical population were not identical. Variance components were estimated based on ssGBLUPm, ssGBLUP, and BLUP, but the values from ssGBLUPm were scaled to provide a fair comparison with estimates from the other two models. In general, additive, residual, and phenotypic variance components in the Hereford population were smaller than in Braford across different models. The addition of genomic information increased heritability for Hereford, possibly because of improved genetic relationships. As expected, genomic models had greater predictive ability, with an additional gain for ssGBLUPm over ssGBLUP. The increase in predictive ability was greater for Herefords. Our results show the potential of using metafounders to increase accuracy of GEBV, and therefore, the rate of genetic gain in beef cattle populations with partial levels of missing pedigree information. Keywords: unknown parent group, founder, genomic selection, missing pedigree, breeding values MenosPedigree information is incomplete by nature and commonly not well-established because many of the genetic ties are not known a priori or can be wrong. The genomic era brought new opportunities to assess relationships between individuals. However, when pedigree and genomic information are used simultaneously, which is the case of single-step genomic BLUP (ssGBLUP), defining the genetic base is still a challenge. One alternative to overcome this challenge is to use metafounders, which are pseudo-individuals that describe the genetic relationship between the base population individuals. The purpose of this study was to evaluate the impact of metafounders on the estimation of breeding values for tick resistance under ssGBLUP for a multibreed population composed by Hereford, Braford, and Zebu animals. Three different scenarios were studied: pedigree-based model (BLUP), ssGBLUP, and ssGBLUP with metafounders (ssGBLUPm). In ssGBLUPm, a total of four different metafounders based on breed of origin (i.e., Hereford, Braford, Zebu, and unknown) were included for the animals with missing parents. The relationship coefficient between metafounders was in average 0.54 (ranging from 0.34 to 0.96) suggesting an overlap between ancestor populations. The estimates of metafounder relationships indicate that Hereford and Zebu breeds have a possible common ancestral relationship. Inbreeding coefficients calculated following the metafounder approach had less negative values, suggesting that ances... Mostrar Tudo |
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Thesagro: |
Bovino; Seleção Genótipa. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/218811/1/fgene.pdf
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Marc: |
LEADER 03145naa a2200205 a 4500
001 2127712
005 2020-12-07
008 2020 bl uuuu u00u1 u #d
100 1 $aJUNQUEIRA, V. S.
245 $aApplying the metafounders approach for genomic evaluation in a multibreed beef cattle population.$h[electronic resource]
260 $c2020
500 $aArticle 556399.
520 $aPedigree information is incomplete by nature and commonly not well-established because many of the genetic ties are not known a priori or can be wrong. The genomic era brought new opportunities to assess relationships between individuals. However, when pedigree and genomic information are used simultaneously, which is the case of single-step genomic BLUP (ssGBLUP), defining the genetic base is still a challenge. One alternative to overcome this challenge is to use metafounders, which are pseudo-individuals that describe the genetic relationship between the base population individuals. The purpose of this study was to evaluate the impact of metafounders on the estimation of breeding values for tick resistance under ssGBLUP for a multibreed population composed by Hereford, Braford, and Zebu animals. Three different scenarios were studied: pedigree-based model (BLUP), ssGBLUP, and ssGBLUP with metafounders (ssGBLUPm). In ssGBLUPm, a total of four different metafounders based on breed of origin (i.e., Hereford, Braford, Zebu, and unknown) were included for the animals with missing parents. The relationship coefficient between metafounders was in average 0.54 (ranging from 0.34 to 0.96) suggesting an overlap between ancestor populations. The estimates of metafounder relationships indicate that Hereford and Zebu breeds have a possible common ancestral relationship. Inbreeding coefficients calculated following the metafounder approach had less negative values, suggesting that ancestral populations were large enough and that gametes inherited from the historical population were not identical. Variance components were estimated based on ssGBLUPm, ssGBLUP, and BLUP, but the values from ssGBLUPm were scaled to provide a fair comparison with estimates from the other two models. In general, additive, residual, and phenotypic variance components in the Hereford population were smaller than in Braford across different models. The addition of genomic information increased heritability for Hereford, possibly because of improved genetic relationships. As expected, genomic models had greater predictive ability, with an additional gain for ssGBLUPm over ssGBLUP. The increase in predictive ability was greater for Herefords. Our results show the potential of using metafounders to increase accuracy of GEBV, and therefore, the rate of genetic gain in beef cattle populations with partial levels of missing pedigree information. Keywords: unknown parent group, founder, genomic selection, missing pedigree, breeding values
650 $aBovino
650 $aSeleção Genótipa
700 1 $aLOPES, P. S.
700 1 $aLOURENCO, D.
700 1 $aSILVA, F. F. e
700 1 $aCARDOSO, F. F.
773 $tFrontiers in Genetics$gv. 11, 556399, Dec. 2020.
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Registro original: |
Embrapa Pecuária Sul (CPPSUL) |
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Registro Completo
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
18/09/2017 |
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Data da última atualização: |
29/12/2017 |
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Autoria: |
GUILHERME, R. F.; AZEVEDO, S. S.; HIGINO, S. S. S.; ALVES, F. S. F.; SANTIAGO, L. B.; LIMA, A. M. C.; PINHEIRO, R. R.; ALVES, C. J. |
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Afiliação: |
Ricardo F. Guilherme, Programa de Pós-Graduação em Medicina Veterinária/Universidade Federal de Campina Grande - UFCG; Sérgio S. Azevedo, Programa de Pós-Graduação em Medicina Veterinária/Universidade Federal de Campina Grande - UFCG; Severino S. S. Higino, Programa de Pós-Graduação em Medicina Veterinária/Universidade Federal de Campina Grande - UFCG; FRANCISCO SELMO FERNANDES ALVES, CNPC; LAUANA BORGES SANTIAGO FERNANDES, CNPC; Ana M. C. Lima, CNPC; RAYMUNDO RIZALDO PINHEIRO, CNPC; Clebert J. Alves, Programa de Pós-Graduação em Medicina Veterinária/Universidade Federal de Campina Grande - UFCG. |
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Título: |
Caracterização epidemiológica e fatores de risco associados à infecção por lentivírus de pequenos ruminantes na região do semiárido paraibano, Nordeste do Brasil. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 6, p. 544-548, jun. 2017. |
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Idioma: |
Português |
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Notas: |
Título em inglês: Epidemiological characterization and risk factors associated with lentivirus infection in small ruminants in the semiarid of Paraíba State, Northeastern Brazil. |
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Conteúdo: |
O objetivo deste estudo foi determinar a soroprevalência de lentivírus de pequenos ruminantes (LVPR) e identificar os fatores de risco para a ocorrência de caprinos e ovinos soropositivos no semiárido do Estado da Paraíba. Foram utilizados 1.733 animais, sendo 1.274 caprinos procedentes de 62 Unidades de Produção (UPs) e 459 ovinos provenientes de 32 UPs. Para o diagnóstico sorológico da infecção por lentivírus foi utilizado o teste de imunodifusão em gel de ágar (IDGA). Dos 1.274 caprinos analisados 15 (1,18%) foram soropositivos, enquanto que todos os 459 ovinos foram soronegativos. Das 62 propriedades caprinas analisadas oito (12,9%) apresentaram pelo menos um animal soropositivo. Os fatores de risco para a ocorrência de caprinos soropositivos foram área da propriedade (odds ratio = 3,28; p = 0,044), ausência de capacitação dos produtores (odds ratio = 8,29; p = 0,042) e uso de monta natural não controlada (odds ratio = 6,78; p = 0,012). Conclui-se que a infecção por lentivírus de pequenos ruminantes, demonstrada pela detecção de anticorpos, está disseminada em rebanhos caprinos do semiárido paraibano, e sugere-se o incentivo à capacitação contínua dos produtores, manutenção de reprodutores negativos ao LVPR e utilização de inseminação artificial com o intuito de evitar o contato físico entre macho e fêmeas. |
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Palavras-Chave: |
Fator de risco; Nordeste brasileiro; Northeastern Brazil; Soroepidemiologia. |
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Thesagro: |
Caprino; Epidemiologia; Ovino. |
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Thesaurus NAL: |
Caprine arthritis encephalitis virus; Epidemiology; Goats; Lentivirus; Risk factors; Serological surveys; Sheep; Small ruminants; Visna maedi virus. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/163933/1/Caracterizacao-epidemiologica-e-fatores-de-risco.pdf
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Marc: |
LEADER 02792naa a2200409 a 4500
001 2075793
005 2017-12-29
008 2017 bl uuuu u00u1 u #d
100 1 $aGUILHERME, R. F.
245 $aCaracterização epidemiológica e fatores de risco associados à infecção por lentivírus de pequenos ruminantes na região do semiárido paraibano, Nordeste do Brasil.$h[electronic resource]
260 $c2017
500 $aTítulo em inglês: Epidemiological characterization and risk factors associated with lentivirus infection in small ruminants in the semiarid of Paraíba State, Northeastern Brazil.
520 $aO objetivo deste estudo foi determinar a soroprevalência de lentivírus de pequenos ruminantes (LVPR) e identificar os fatores de risco para a ocorrência de caprinos e ovinos soropositivos no semiárido do Estado da Paraíba. Foram utilizados 1.733 animais, sendo 1.274 caprinos procedentes de 62 Unidades de Produção (UPs) e 459 ovinos provenientes de 32 UPs. Para o diagnóstico sorológico da infecção por lentivírus foi utilizado o teste de imunodifusão em gel de ágar (IDGA). Dos 1.274 caprinos analisados 15 (1,18%) foram soropositivos, enquanto que todos os 459 ovinos foram soronegativos. Das 62 propriedades caprinas analisadas oito (12,9%) apresentaram pelo menos um animal soropositivo. Os fatores de risco para a ocorrência de caprinos soropositivos foram área da propriedade (odds ratio = 3,28; p = 0,044), ausência de capacitação dos produtores (odds ratio = 8,29; p = 0,042) e uso de monta natural não controlada (odds ratio = 6,78; p = 0,012). Conclui-se que a infecção por lentivírus de pequenos ruminantes, demonstrada pela detecção de anticorpos, está disseminada em rebanhos caprinos do semiárido paraibano, e sugere-se o incentivo à capacitação contínua dos produtores, manutenção de reprodutores negativos ao LVPR e utilização de inseminação artificial com o intuito de evitar o contato físico entre macho e fêmeas.
650 $aCaprine arthritis encephalitis virus
650 $aEpidemiology
650 $aGoats
650 $aLentivirus
650 $aRisk factors
650 $aSerological surveys
650 $aSheep
650 $aSmall ruminants
650 $aVisna maedi virus
650 $aCaprino
650 $aEpidemiologia
650 $aOvino
653 $aFator de risco
653 $aNordeste brasileiro
653 $aNortheastern Brazil
653 $aSoroepidemiologia
700 1 $aAZEVEDO, S. S.
700 1 $aHIGINO, S. S. S.
700 1 $aALVES, F. S. F.
700 1 $aSANTIAGO, L. B.
700 1 $aLIMA, A. M. C.
700 1 $aPINHEIRO, R. R.
700 1 $aALVES, C. J.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 37, n. 6, p. 544-548, jun. 2017.
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