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Registro Completo |
Biblioteca(s): |
Embrapa Unidades Centrais. |
Data corrente: |
19/11/1997 |
Data da última atualização: |
19/11/1997 |
Autoria: |
HOUGH, G. W. |
Título: |
Technology diffusion: federal programs & procedures. |
Ano de publicação: |
1975 |
Fonte/Imprenta: |
Mt. Airy: Lomond Books, 1975. |
Páginas: |
406p. |
ISBN: |
0-912-338-05-9 |
Idioma: |
Inglês |
Conteúdo: |
Technology potential; Conceptual models for diffusing technology; U.S. technology diffusion activities: background; Department of agriculture; Public health service; Department of defense; Technology diffusion activities of other agencies; Comparative analysis of programs and procedures. |
Palavras-Chave: |
Difusao; Innovation; Programacao; Programming. |
Thesagro: |
Inovação; Tecnologia. |
Thesaurus Nal: |
diffusion; technology. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00837nam a2200229 a 4500 001 1098959 005 1997-11-19 008 1975 bl uuuu 00u1 u #d 020 $a0-912-338-05-9 100 1 $aHOUGH, G. W. 245 $aTechnology diffusion$bfederal programs & procedures. 260 $aMt. Airy: Lomond Books$c1975 300 $a406p. 520 $aTechnology potential; Conceptual models for diffusing technology; U.S. technology diffusion activities: background; Department of agriculture; Public health service; Department of defense; Technology diffusion activities of other agencies; Comparative analysis of programs and procedures. 650 $adiffusion 650 $atechnology 650 $aInovação 650 $aTecnologia 653 $aDifusao 653 $aInnovation 653 $aProgramacao 653 $aProgramming
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Embrapa Unidades Centrais (AI-SEDE) |
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Registro Completo
Biblioteca(s): |
Embrapa Agricultura Digital. |
Data corrente: |
15/12/2022 |
Data da última atualização: |
01/03/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
BARRETO, P.; DAMBIRE, C.; SHARMA, G.; VICENTE, J.; OSBORNE, R.; YASSITEPE, J. E. de C. T.; GIBBS, D. J.; MAIA, I. G.; HOLDSWORTH, M. J.; ARRUDA, P. |
Afiliação: |
PEDRO BARRETO, UNIVERSIDADE ESTADUAL PAULISTA; CHARLENE DAMBIRE, UNIVERSITY OF NOTTINGHAM; GUNJAN SHARMA, UNIVERSITY OF NOTTINGHAM; JORGE VICENTE, UNIVERSITY OF NOTTINGHAM; RORY OSBORNE, UNIVERSITY OF BIRMINGHAM; JULIANA ERIKA DE C T YASSITEPE, CNPTIA; DANIEL J. GIBBS, UNIVERSITY OF BIRMINGHAM; IVAN G. MAIA, UNIVERSIDADE ESTADUAL PAULISTA; MICHAEL J. HOLDSWORTH, UNIVERSITY OF NOTTINGHAM; PAULO ARRUDA, UNIVERSIDADE ESTADUAL DE CAMPINAS. |
Título: |
Mitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Current Biology, v. 32, n. 6, p. 1403-1411, Mar. 2022. |
DOI: |
https://doi.org/10.1016/j.cub.2022.01.037 |
Idioma: |
Inglês |
Notas: |
Short communication. Na publicação: Juliana Yassitepe. |
Conteúdo: |
SUMMARY. Mitochondrial retrograde signaling is an important component of intracellular stress signaling in eukaryotes. UNCOUPLING PROTEIN (UCP)1 is an abundant plant inner-mitochondrial membrane protein with multiple functions including uncoupled respiration and amino-acid transport1,2 that influences broad abiotic stress responses. Although the mechanism(s) through which this retrograde function acts is unknown, overexpression of UCP1 activates expression of hypoxia (low oxygen)-associated nuclear genes.3,4 Here we show in Arabidopsis thaliana that UCP1 influences nuclear gene expression and physiological response by inhibiting the cytoplasmic PLANT CYSTEINE OXIDASE (PCO) branch of the PROTEOLYSIS (PRT)6 N-degron pathway, a major mechanism of oxygen and nitric oxide (NO) sensing.5 Overexpression of UCP1 (UCP1ox) resulted in the stabilization of an artificial PCO N-degron pathway substrate, and stability of this reporter protein was influenced by pharmacological interventions that control UCP1 activity. Hypoxia and salt-tolerant phenotypes observed in UCP1ox lines resembled those observed for the PRT6 N-recognin E3 ligase mutant prt6-1. Genetic analysis showed that UCP1 regulation of hypoxia responses required the activity of PCO N-degron pathway ETHYLENE RESPONSE FACTOR (ERF)VII substrates. Transcript expression analysis indicated that UCP1 regulation of hypoxia-related gene expression is a normal component of seedling development. Our results show that mitochondrial retrograde signaling represses the PCO N-degron pathway, enhancing substrate function, thus facilitating downstream stress responses. This work reveals a novel mechanism through which mitochondrial retrograde signaling influences nuclear response to hypoxia by inhibition of an ancient cytoplasmic pathway of eukaryotic oxygen sensing. MenosSUMMARY. Mitochondrial retrograde signaling is an important component of intracellular stress signaling in eukaryotes. UNCOUPLING PROTEIN (UCP)1 is an abundant plant inner-mitochondrial membrane protein with multiple functions including uncoupled respiration and amino-acid transport1,2 that influences broad abiotic stress responses. Although the mechanism(s) through which this retrograde function acts is unknown, overexpression of UCP1 activates expression of hypoxia (low oxygen)-associated nuclear genes.3,4 Here we show in Arabidopsis thaliana that UCP1 influences nuclear gene expression and physiological response by inhibiting the cytoplasmic PLANT CYSTEINE OXIDASE (PCO) branch of the PROTEOLYSIS (PRT)6 N-degron pathway, a major mechanism of oxygen and nitric oxide (NO) sensing.5 Overexpression of UCP1 (UCP1ox) resulted in the stabilization of an artificial PCO N-degron pathway substrate, and stability of this reporter protein was influenced by pharmacological interventions that control UCP1 activity. Hypoxia and salt-tolerant phenotypes observed in UCP1ox lines resembled those observed for the PRT6 N-recognin E3 ligase mutant prt6-1. Genetic analysis showed that UCP1 regulation of hypoxia responses required the activity of PCO N-degron pathway ETHYLENE RESPONSE FACTOR (ERF)VII substrates. Transcript expression analysis indicated that UCP1 regulation of hypoxia-related gene expression is a normal component of seedling development. Our results show that mitochondrial retrog... Mostrar Tudo |
Palavras-Chave: |
Expressão gênica; Resposta fisiológica. |
Thesagro: |
Mitocôndria. |
Thesaurus NAL: |
Arabidopsis thaliana; Gene expression; Gene overexpression; Hypoxia. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1149731/1/AP-Mitochondrial-retrograde-2022.pdf
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Marc: |
LEADER 02869naa a2200337 a 4500 001 2149731 005 2023-03-01 008 2022 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.cub.2022.01.037$2DOI 100 1 $aBARRETO, P. 245 $aMitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway.$h[electronic resource] 260 $c2022 500 $aShort communication. Na publicação: Juliana Yassitepe. 520 $aSUMMARY. Mitochondrial retrograde signaling is an important component of intracellular stress signaling in eukaryotes. UNCOUPLING PROTEIN (UCP)1 is an abundant plant inner-mitochondrial membrane protein with multiple functions including uncoupled respiration and amino-acid transport1,2 that influences broad abiotic stress responses. Although the mechanism(s) through which this retrograde function acts is unknown, overexpression of UCP1 activates expression of hypoxia (low oxygen)-associated nuclear genes.3,4 Here we show in Arabidopsis thaliana that UCP1 influences nuclear gene expression and physiological response by inhibiting the cytoplasmic PLANT CYSTEINE OXIDASE (PCO) branch of the PROTEOLYSIS (PRT)6 N-degron pathway, a major mechanism of oxygen and nitric oxide (NO) sensing.5 Overexpression of UCP1 (UCP1ox) resulted in the stabilization of an artificial PCO N-degron pathway substrate, and stability of this reporter protein was influenced by pharmacological interventions that control UCP1 activity. Hypoxia and salt-tolerant phenotypes observed in UCP1ox lines resembled those observed for the PRT6 N-recognin E3 ligase mutant prt6-1. Genetic analysis showed that UCP1 regulation of hypoxia responses required the activity of PCO N-degron pathway ETHYLENE RESPONSE FACTOR (ERF)VII substrates. Transcript expression analysis indicated that UCP1 regulation of hypoxia-related gene expression is a normal component of seedling development. Our results show that mitochondrial retrograde signaling represses the PCO N-degron pathway, enhancing substrate function, thus facilitating downstream stress responses. This work reveals a novel mechanism through which mitochondrial retrograde signaling influences nuclear response to hypoxia by inhibition of an ancient cytoplasmic pathway of eukaryotic oxygen sensing. 650 $aArabidopsis thaliana 650 $aGene expression 650 $aGene overexpression 650 $aHypoxia 650 $aMitocôndria 653 $aExpressão gênica 653 $aResposta fisiológica 700 1 $aDAMBIRE, C. 700 1 $aSHARMA, G. 700 1 $aVICENTE, J. 700 1 $aOSBORNE, R. 700 1 $aYASSITEPE, J. E. de C. T. 700 1 $aGIBBS, D. J. 700 1 $aMAIA, I. G. 700 1 $aHOLDSWORTH, M. J. 700 1 $aARRUDA, P. 773 $tCurrent Biology$gv. 32, n. 6, p. 1403-1411, Mar. 2022.
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