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Registro Completo |
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
04/03/2016 |
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Data da última atualização: |
28/04/2016 |
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Autoria: |
FERNANDO, F. S.; OKINO, C. H.; SILVA, K. R.; FERNANDES, C. C.; GONÇALVES, M. C. M.; MONTASSIER, M. F. S.; VASCONCELOS, R. O.; MONTASSIER, H. J. |
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Afiliação: |
FILIPE S. FERNANDO, FCAV/UNESP; CINTIA HIROMI OKINO, CNPSA; KETHERSON R. SILVA, FCAV/UNESP; CAMILA C. FERNANDES, FCAV/UNESP; MARIANA C. M. GONÇALVES, FCAV/UNESP; MARIA F. S. MONTASSIER, FCAV/UNESP; ROSEMERI O. VASCONCELOS, FCAV/UNESP; HELIO J. MONTASSIER, FACV/UNESP. |
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Título: |
Increased expression of Interleukin-6 related to nephritis in chickens challenged with an Avian infectious bronchitis virus variant. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Brasília, DF, v. 35, n. 3, p. 216-222, mar. 2015. |
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Idioma: |
Inglês |
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Conteúdo: |
A Brazilian field isolate (IBV/Brazil/PR05) of avian infectious bronchitis virus (IBV), associated with development of nephritis in chickens, was previously genotyped as IBV variant after S1 gene sequencing. The aim of this study was to evaluate the levels of IL-6 in kidneys and trachea of birds vaccinated and challenged with IBV/Brazil/PR05 strain, correlating these results with scores of microscopic lesions, specific IBV antigen detection and viral load. The up-regulation of IL-6 and the increased levels of viral load on renal and tracheal samples were significantly correlated with scores of microscopic lesions. Reduced levels of viral load were detected in kidneys of birds previously vaccinated and challenged, compared to non-vaccinated challenged group, although markedly microscopic lesions were observed for both groups. The expression of IL-6, present both in the kidney and in the tracheas, was dependent on the load of the virus present in the tissue, and the development of lesions was related with IL-6 present in the tissues. These data suggest that variant IBV/Brazil/PR05 can induce the expression of proinflammatory cytokines in a manner correlated with viral load and increased IL-6 is involved in the tissue with the influx of inflammatory cells and subsequent nephritis. This may contribute with a model to the development of immunosuppressive agents of IL-6 to prevent acute inflammatory processes against infection with IBV and perhaps other coronaviruses, as well as contribute to the understanding of the immunopathogenesis of IBV nephropatogenic strains. MenosA Brazilian field isolate (IBV/Brazil/PR05) of avian infectious bronchitis virus (IBV), associated with development of nephritis in chickens, was previously genotyped as IBV variant after S1 gene sequencing. The aim of this study was to evaluate the levels of IL-6 in kidneys and trachea of birds vaccinated and challenged with IBV/Brazil/PR05 strain, correlating these results with scores of microscopic lesions, specific IBV antigen detection and viral load. The up-regulation of IL-6 and the increased levels of viral load on renal and tracheal samples were significantly correlated with scores of microscopic lesions. Reduced levels of viral load were detected in kidneys of birds previously vaccinated and challenged, compared to non-vaccinated challenged group, although markedly microscopic lesions were observed for both groups. The expression of IL-6, present both in the kidney and in the tracheas, was dependent on the load of the virus present in the tissue, and the development of lesions was related with IL-6 present in the tissues. These data suggest that variant IBV/Brazil/PR05 can induce the expression of proinflammatory cytokines in a manner correlated with viral load and increased IL-6 is involved in the tissue with the influx of inflammatory cells and subsequent nephritis. This may contribute with a model to the development of immunosuppressive agents of IL-6 to prevent acute inflammatory processes against infection with IBV and perhaps other coronaviruses, as well as c... Mostrar Tudo |
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Palavras-Chave: |
Variant strain; Vírus da bronquite infecciosa. |
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Thesagro: |
Galinha; Nefrite. |
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Thesaurus Nal: |
Chickens; Infectious bronchitis virus; Interleukin-6; Nephritis. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/140631/1/Increased-expression.pdf
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Marc: |
LEADER 02514naa a2200301 a 4500
001 2039633
005 2016-04-28
008 2015 bl uuuu u00u1 u #d
100 1 $aFERNANDO, F. S.
245 $aIncreased expression of Interleukin-6 related to nephritis in chickens challenged with an Avian infectious bronchitis virus variant.
260 $c2015
520 $aA Brazilian field isolate (IBV/Brazil/PR05) of avian infectious bronchitis virus (IBV), associated with development of nephritis in chickens, was previously genotyped as IBV variant after S1 gene sequencing. The aim of this study was to evaluate the levels of IL-6 in kidneys and trachea of birds vaccinated and challenged with IBV/Brazil/PR05 strain, correlating these results with scores of microscopic lesions, specific IBV antigen detection and viral load. The up-regulation of IL-6 and the increased levels of viral load on renal and tracheal samples were significantly correlated with scores of microscopic lesions. Reduced levels of viral load were detected in kidneys of birds previously vaccinated and challenged, compared to non-vaccinated challenged group, although markedly microscopic lesions were observed for both groups. The expression of IL-6, present both in the kidney and in the tracheas, was dependent on the load of the virus present in the tissue, and the development of lesions was related with IL-6 present in the tissues. These data suggest that variant IBV/Brazil/PR05 can induce the expression of proinflammatory cytokines in a manner correlated with viral load and increased IL-6 is involved in the tissue with the influx of inflammatory cells and subsequent nephritis. This may contribute with a model to the development of immunosuppressive agents of IL-6 to prevent acute inflammatory processes against infection with IBV and perhaps other coronaviruses, as well as contribute to the understanding of the immunopathogenesis of IBV nephropatogenic strains.
650 $aChickens
650 $aInfectious bronchitis virus
650 $aInterleukin-6
650 $aNephritis
650 $aGalinha
650 $aNefrite
653 $aVariant strain
653 $aVírus da bronquite infecciosa
700 1 $aOKINO, C. H.
700 1 $aSILVA, K. R.
700 1 $aFERNANDES, C. C.
700 1 $aGONÇALVES, M. C. M.
700 1 $aMONTASSIER, M. F. S.
700 1 $aVASCONCELOS, R. O.
700 1 $aMONTASSIER, H. J.
773 $tPesquisa Veterinária Brasileira, Brasília, DF$gv. 35, n. 3, p. 216-222, mar. 2015.
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Registro original: |
Embrapa Unidades Centrais (AI-SEDE) |
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| Registros recuperados : 53 | |
| 3. |  | GONÇALVES, M. C. A.; SEGOVIA, J. F. O. Unha-de-gato, usos medicinais, ocorrência e conservação a campo no Amapá, Brasil. In: REUNIÃO ANUAL DO INSTITUTO BIOLÓGICO, 16.; CONGRESSO DE INICIAÇÃO CIENTÍFICA EM CIÊNCIAS AGRÁRIAS, BIOLÓGICAS E AMBIENTAIS, 1., 2003, São Paulo. [Anais.] São Paulo: Instituto Biológico, 2003. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amapá. |
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| 7. | | CARPEJANI, G. C.; LEMPP, B.; MEDEIROS, S. R.; JANK, L.; GONÇALVES, M. C.; GOMES, R. A. Acúmulo de massa, composição química e digestibilidade in vitro em genótipos de Panicum maximum. In: JORNADA CIENTÍFICA DA EMBRAPA GADO DE CORTE, 2., 2006, Campo Grande, MS. Anais [da]... 2. ed. Campo Grande, MS: Embrapa Gado de Corte, 2006. 1 p. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Corte. |
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| 8. | | GONÇALVES, M. C.; GALDEANO, D. M.; MAIA, I. de G.; CHAGAS, C. M. Variabilidade genética de Sugarcane mosaic virus, causando mosaico em milho no Brasil Pesquisa Agropecuária Brasileira, Brasília, DF, v. 46, n. 4, p. 362-369, abril 2011 Título em inglês: Genetic variability of Sugarcane mosaic virus causing maize mosaic in Brazil.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 9. | | CARPEJANI, G. C.; LEMPP, B.; MEDEIROS, S. R.; JANK, L.; GONÇALVES, M. C.; GOMES, R. A. Fração indigestível da fibra em detergente neutro da lâmina foliar de genótipos de Panicum maximum. In: JORNADA CIENTÍFICA DA EMBRAPA GADO DE CORTE, 3., 2007, Campo Grande, MS. Anais [da]... Campo Grande, MS: Embrapa Gado de Corte, 2007. p. 17 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Corte. |
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| 12. | | RIVAS, E. B.; BÔDI, E. C. de A.; HARAKAVA, R.; GREGORI, F.; GONÇALVES, M. C. Occurrence and molecular analysis of quarantine virus in lily cultivation areas in Brazil. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 51, n. 5, p. 615-622, maio 2016. Título em português: Ocorrência e análise molecular de vírus quarentenário em áreas de cultivo de lírios no Brasil.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 15. | | BEZERRA, F. P. C. A.; SILVEIRA, D.; KANZAKI, L. I. B.; GONÇALVES, M. C. A.; SEGOVIA, J. F. O. Alelopatia de Carapa guianensis na germinação e no comprimento de Lactuca sativa. In: SIMPÓSIO NACIONAL CERRADO, 9.; SIMPÓSIO INTERNACIONAL SAVANAS TROPICAIS, 2., 2008, Brasília, DF. Desafios e estratégias para o equilíbrio entre sociedade, agronegócio e recursos naturais: anais... Planaltina, DF: Embrapa Cerrados, 2008. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Amapá. |
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| 16. | | URANO, E. O. M.; KURIHARA, C. H.; MAEDA, S.; VITORINO, A. C. T.; GONÇALVES, M. C.; MARCHETTI, M. E. Avaliação do estado nutricional da soja. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 41, n. 9, p. 1421-1428, set. 2006.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Agropecuária Oeste; Embrapa Unidades Centrais. |
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| 17. | | VICTOR, D. M.; JANK, L.; LEMPP, B.; SIMEÃO, R. M.; RESENDE, M. D. V. de; GONÇALVES, M. C. Selection of full-sib families of Panicum maximum Jacq under low light conditions. Revista Ceres, Viçosa, v.62, n.2, p.199-207, mar-abr, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Florestas; Embrapa Gado de Corte. |
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| 18. | | NUNES, A. da S.; LOURENÇÃO, A. L. F.; PEZARICO, C. R.; SCALON, S. de P. Q.; GONÇALVES, M. C. Fontes e níveis de salinidade na germinação de Crotalaria juncea L. Ciência e Agrotecnologia, v. 33, n. 3, p. 753-764, maio/jun., 2009| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 19. | | UTIDA, R. H.; COSTA, G. T.; BRANDAO, R. L.; GONCALVES, M. C. A.; CARNEIRO, N. P.; CARNEIRO, A. A. Co-transformação de milho com cassetes de expressão mínimos dos genes bar e uidA. In: CONGRESSO NACIONAL DE MILHO E SORGO, 25.; SIMPOSIO BRASILEIRO SOBRE A LAGARTA-DO-CARTUCHO, SPODOPTERA FRUGIPERDA, 1., 2004, Cuiabá, MT. Da agricultura familiar ao agronegócio: tecnologia, competitividade e sustentabilidade: [resumos expandidos]. Sete Lagoas: ABMS: Embrapa Milho e Sorgo; Cuiabá: Empaer, 2004. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| Registros recuperados : 53 | |
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