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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sul. Para informações adicionais entre em contato com cppsul.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sul. |
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Data corrente: |
25/10/2021 |
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Data da última atualização: |
10/12/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
COMIN, H. B.; SOLLERO, B. P.; GASPAR, E. B.; DOMINGUES, R.; CARDOSO, F. F. |
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Afiliação: |
H. B. COMIN, UFPEL; BRUNA PENA SOLLERO, CPPSUL; EMANUELLE BALDO GASPAR, CPPSUL; ROBERT DOMINGUES, CPPSUL; FERNANDO FLORES CARDOSO, CPPSUL. |
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Título: |
Genome-wide association study of resistance/susceptibility to infectious bovine keratoconjunctivitis in Brazilian Hereford cattle. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Animal Genetics, v. 52, n. 6, p. 881-886, Dec. 2021. |
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Idioma: |
Inglês |
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Conteúdo: |
Genome-wide association studies were conducted to identify the more informative genomic regions and SNPs, as well as to identify candidate genes associated with infectious bovine keratoconjunctivitis (IBK) resistance/susceptibility in Hereford cattle. A Bayes B statistical approach was initially applied in genome-wide association studies by using deregressed estimated breeding values for IBK resistance/susceptibility. To estimate the combined effect of a genomic region that is potentially associated with QTL, 2504 non-overlapping 1-Mb windows that varied in SNP number were defined, with the most informative 24 windows including 427 SNPs and explaining more than 20% of the estimated genetic variance for IBK resistance/susceptibility. These regions were explored with respect to their biological functions through functional analysis to map potential candidate genes. The significant SNPs were mapped on chromosomes 1, 3, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 18, 20, 23, and 28, and candidate genes were detected as related to the IBK. Most informative SNPs in term of genetic variance were located in proximity of genes related to phenotypic expression of lesions and biological processes associated to the IBK. Knowledge about phenotypic and genomic variation generated in the present study can be used to on design selection strategies to improve the resistance to IBK of Hereford cattle herds. Keywords Bayesian inference, beef cattle, candidate genes, functional analysis |
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Thesagro: |
Conjuntivite; Doença Animal; Olho; Queratite. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02152naa a2200217 a 4500
001 2135552
005 2021-12-10
008 2021 bl uuuu u00u1 u #d
100 1 $aCOMIN, H. B.
245 $aGenome-wide association study of resistance/susceptibility to infectious bovine keratoconjunctivitis in Brazilian Hereford cattle.$h[electronic resource]
260 $c2021
520 $aGenome-wide association studies were conducted to identify the more informative genomic regions and SNPs, as well as to identify candidate genes associated with infectious bovine keratoconjunctivitis (IBK) resistance/susceptibility in Hereford cattle. A Bayes B statistical approach was initially applied in genome-wide association studies by using deregressed estimated breeding values for IBK resistance/susceptibility. To estimate the combined effect of a genomic region that is potentially associated with QTL, 2504 non-overlapping 1-Mb windows that varied in SNP number were defined, with the most informative 24 windows including 427 SNPs and explaining more than 20% of the estimated genetic variance for IBK resistance/susceptibility. These regions were explored with respect to their biological functions through functional analysis to map potential candidate genes. The significant SNPs were mapped on chromosomes 1, 3, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 18, 20, 23, and 28, and candidate genes were detected as related to the IBK. Most informative SNPs in term of genetic variance were located in proximity of genes related to phenotypic expression of lesions and biological processes associated to the IBK. Knowledge about phenotypic and genomic variation generated in the present study can be used to on design selection strategies to improve the resistance to IBK of Hereford cattle herds. Keywords Bayesian inference, beef cattle, candidate genes, functional analysis
650 $aConjuntivite
650 $aDoença Animal
650 $aOlho
650 $aQueratite
700 1 $aSOLLERO, B. P.
700 1 $aGASPAR, E. B.
700 1 $aDOMINGUES, R.
700 1 $aCARDOSO, F. F.
773 $tAnimal Genetics$gv. 52, n. 6, p. 881-886, Dec. 2021.
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Registro original: |
Embrapa Pecuária Sul (CPPSUL) |
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Registro Completo
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Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
09/08/2005 |
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Data da última atualização: |
12/05/2022 |
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Autoria: |
KIRST, M.; BRONDANI, R. P. V.; BRONDANI, C.; GRATTAPAGLIA, D. |
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Título: |
Screening of designed primer pairs of recovery of microsatellite markers and their transferability among species of Eucalyptus. |
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Ano de publicação: |
1997 |
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Fonte/Imprenta: |
In: IUFRO CONFERENCE ON SILVICULTURE AND IMPROVEMENT EUCALYPTS=CONFERÊNCIA IUFRO SOBRE SILVICULTURA E MELHORAMENTO DE EUCALIPTOS, 1997, Salvador. Proceedings...=Anais... Colombo: EMBRAPA-CNPF, 1997. v. 2. |
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Páginas: |
p. 167-171. |
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Idioma: |
Inglês |
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Palavras-Chave: |
Marcadores microssatélites. |
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Thesagro: |
Eucalipto. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 00738nam a2200169 a 4500
001 1185929
005 2022-05-12
008 1997 bl uuuu u00u1 u #d
100 1 $aKIRST, M.
245 $aScreening of designed primer pairs of recovery of microsatellite markers and their transferability among species of Eucalyptus.$h[electronic resource]
260 $aIn: IUFRO CONFERENCE ON SILVICULTURE AND IMPROVEMENT EUCALYPTS=CONFERÊNCIA IUFRO SOBRE SILVICULTURA E MELHORAMENTO DE EUCALIPTOS, 1997, Salvador. Proceedings...=Anais... Colombo: EMBRAPA-CNPF, 1997. v. 2.$c1997
300 $ap. 167-171.
650 $aEucalipto
653 $aMarcadores microssatélites
700 1 $aBRONDANI, R. P. V.
700 1 $aBRONDANI, C.
700 1 $aGRATTAPAGLIA, D.
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Embrapa Recursos Genéticos e Biotecnologia (CENARGEN) |
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