Registro Completo |
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
28/05/2003 |
Data da última atualização: |
25/08/2023 |
Autoria: |
FU, H.; LEAKE, C. J.; MERTENS, P. P. C.; MELLOR, P. S. |
Título: |
The barriers to bluetongue virus infection, dissemination and transmission in the vector, Culicoides variipennis (Diptera: Ceratopogonidae). |
Ano de publicação: |
1999 |
Fonte/Imprenta: |
Archives of Virology, v. 144, n. 4, p. 747-761, 1999. |
DOI: |
10.1007/s007050050540. |
Idioma: |
Inglês |
Conteúdo: |
Transmission of bluetongue virus (BTV) by a vector species of Culicoides was studied using immunohistochemistry, virus titration and in vitro transmission tests. Adult female C. variipennis were used from two colonies that are either "transmission competent" or "transmission refractory" after oral infection with BTV. Intrathoracic (IT) injection of BTV into the haemocoel always resulted in a fully disseminated infection and transmission of virus in saliva. However, after ingestion of an infectious blood meal, only 30% (approximately) of midges from either colony became persistently infected. Although none of the orally infected insects from the "refractory" colony were able to transmit virus, 12% of those from the "competent" colony (containing 103.oTCillso of virus/midge) did transmit BTV in their saliva. The most important barriers to BTV transmission in Culicoides vector species appeared to be a mesenteron infection barrier (MIB), which controls initial establishment of persistent infection, a mesenteron escape barrier (MEB) which can restrict virus to gut cells and a dissemination barrier (DB) which can prevent virus which enters the haemocoel from infecting secondary target organs. Culicoides variipennis do not appear to present either a salivary gland infection barrier (SGIB), or a salivary gland escape barrier (SGEB) to BTV. |
Palavras-Chave: |
Drug effects. |
Thesagro: |
Doença Animal; Língua Azul; Vetor; Vírus. |
Thesaurus Nal: |
Bluetongue virus; Ceratopogonidae; Culicoides variipennis; Disease transmission; Immunohistochemistry; Insect vectors; Malathion; Pharmacology; Salivation; Sheep diseases; Virus replication; Virus transmission. |
Categoria do assunto: |
H Saúde e Patologia |
Marc: |
LEADER 02448naa a2200373 a 4500 001 1529338 005 2023-08-25 008 1999 bl uuuu u00u1 u #d 024 7 $a10.1007/s007050050540.$2DOI 100 1 $aFU, H. 245 $aThe barriers to bluetongue virus infection, dissemination and transmission in the vector, Culicoides variipennis (Diptera$bCeratopogonidae).$h[electronic resource] 260 $c1999 520 $aTransmission of bluetongue virus (BTV) by a vector species of Culicoides was studied using immunohistochemistry, virus titration and in vitro transmission tests. Adult female C. variipennis were used from two colonies that are either "transmission competent" or "transmission refractory" after oral infection with BTV. Intrathoracic (IT) injection of BTV into the haemocoel always resulted in a fully disseminated infection and transmission of virus in saliva. However, after ingestion of an infectious blood meal, only 30% (approximately) of midges from either colony became persistently infected. Although none of the orally infected insects from the "refractory" colony were able to transmit virus, 12% of those from the "competent" colony (containing 103.oTCillso of virus/midge) did transmit BTV in their saliva. The most important barriers to BTV transmission in Culicoides vector species appeared to be a mesenteron infection barrier (MIB), which controls initial establishment of persistent infection, a mesenteron escape barrier (MEB) which can restrict virus to gut cells and a dissemination barrier (DB) which can prevent virus which enters the haemocoel from infecting secondary target organs. Culicoides variipennis do not appear to present either a salivary gland infection barrier (SGIB), or a salivary gland escape barrier (SGEB) to BTV. 650 $aBluetongue virus 650 $aCeratopogonidae 650 $aCulicoides variipennis 650 $aDisease transmission 650 $aImmunohistochemistry 650 $aInsect vectors 650 $aMalathion 650 $aPharmacology 650 $aSalivation 650 $aSheep diseases 650 $aVirus replication 650 $aVirus transmission 650 $aDoença Animal 650 $aLíngua Azul 650 $aVetor 650 $aVírus 653 $aDrug effects 700 1 $aLEAKE, C. J. 700 1 $aMERTENS, P. P. C. 700 1 $aMELLOR, P. S. 773 $tArchives of Virology$gv. 144, n. 4, p. 747-761, 1999.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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