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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
09/02/2023 |
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Data da última atualização: |
10/02/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
AFONSO, J.; SHIM, W. J.; BODEN, M.; FORTES, M. R. S.; DINIZ, W. J. da S.; LIMA, A. O. de; ROCHA, M. I. P.; CARDOSO, T. F.; BRUSCADIN, J. J.; GROMBONI, C. F.; NOGUEIRA, A. R. A.; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L.; REGITANO, L. C. de A. |
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Afiliação: |
JULIANA AFONSO; WOO JUN SHIM, THE UNIVERSITY OF QUEENSLAND; MIKAEL BODEN, THE UNIVERSITY OF QUEENSLAND; MARINA RUFINO SALINAS FORTES, THE UNIVERSITY OF QUEENSLAND; WELLISON JARLES DA SILVA DINIZ, AUBURN UNIVERSITY; ANDRESSA OLIVEIRA DE LIMA, UNIVERSITY OF WASHINGTON; MARINA IBELLI PEREIRA ROCHA, UNIVERSIDADE FEDERAL DE SÃO CARLOS; TAINÃ FIGUEIREDO CARDOSO; JENNIFER JESSICA BRUSCADIN, UNIVERSIDADE FEDERAL DE SÃO CARLOS; CAIO FERNANDO GROMBONI, INSTITUTO FEDERAL DE EDUCAÇÃO, CIÊNCIA E TECNOLOGIA DA BAHIA; ANA RITA ARAUJO NOGUEIRA; GERSON BARRETO MOURÃO, UNIVERSIDADE DE SÃO PAULO; ADHEMAR ZERLOTINI NETO, CNPTIA; LUIZ LEHMANN COUTINHO, UNIVERSIDADE DE SÃO PAULO; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Repressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Biochemistry and Biophysics Reports, v. 33, 101420, Mar. 2023. |
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DOI: |
https://doi.org/10.1016/j.bbrep.2023.101420 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expression profiles observed in muscle samples with contrasting mineral content through the candidate regulators here identified. MenosAbstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expressio... Mostrar Tudo |
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Palavras-Chave: |
Epigenetic regulation; Expressão gênica; Gene repression; H3K27me3. |
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Thesagro: |
Bos Indicus; Gado de Corte; Gado Nelore; Mineral. |
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Thesaurus Nal: |
Epigenetics; Gene expression; Minerals. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1151623/1/AP-Repressive-epigenetic-2023.pdf
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Marc: |
LEADER 02933naa a2200433 a 4500
001 2151623
005 2023-02-10
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.bbrep.2023.101420$2DOI
100 1 $aAFONSO, J.
245 $aRepressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle.$h[electronic resource]
260 $c2023
520 $aAbstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expression profiles observed in muscle samples with contrasting mineral content through the candidate regulators here identified.
650 $aEpigenetics
650 $aGene expression
650 $aMinerals
650 $aBos Indicus
650 $aGado de Corte
650 $aGado Nelore
650 $aMineral
653 $aEpigenetic regulation
653 $aExpressão gênica
653 $aGene repression
653 $aH3K27me3
700 1 $aSHIM, W. J.
700 1 $aBODEN, M.
700 1 $aFORTES, M. R. S.
700 1 $aDINIZ, W. J. da S.
700 1 $aLIMA, A. O. de
700 1 $aROCHA, M. I. P.
700 1 $aCARDOSO, T. F.
700 1 $aBRUSCADIN, J. J.
700 1 $aGROMBONI, C. F.
700 1 $aNOGUEIRA, A. R. A.
700 1 $aMOURÃO, G. B.
700 1 $aZERLOTINI NETO, A.
700 1 $aCOUTINHO, L. L.
700 1 $aREGITANO, L. C. de A.
773 $tBiochemistry and Biophysics Reports$gv. 33, 101420, Mar. 2023.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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| Registros recuperados : 22 | |
| 11. |  | BRITO, F. C. de; ÁVILA, S.; PACHECO, S. D. G.; SILVEIRA, A. C. da; VARGAS, V. M. F.; LAZZAROTTO, M. Avaliação do desenvolvimento dos frutos de Ilex paraguariensis St.Hil. In: SEMANA DE APERFEIÇOAMENTO EM ENGENHARIA FLORESTAL DA UFPR, 2., 2018, Curitiba. Anais. Curitiba: CIFLOMA, 2018. 4 p.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Florestas. |
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| 12. | | SIQUEIRA, G. L. de A. de; HORNUNG, P. S.; SILVEIRA, A. C. da; LAZZAROTTO, S. R. da S.; CORDOBA, L. do P.; SCHNITZLER, E.; LAZZAROTTO, M. Impact of treatment with HCL/alcoholic in the modification of corn starch. Journal of Thermal Analysis and Calorimetry, v. 129, n. 3, p. 1705-1713, Dec. 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Florestas. |
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| 13. | | LAZZAROTTO, S. R. da S.; SCHERRUTH, M. S. de F.; CALIXTO, P. S.; CARRARO, M. de M.; SILVEIRA, A. C. da; LAZZAROTTO, M. Método de Folin Ciocalteau adaptado para quantificar polifenóis em extratos de erva-mate. Movimenta, v. 13, n. 3, p. 419-426, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 4 |
| Biblioteca(s): Embrapa Florestas. |
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| 14. | | SILVEIRA, A. C. da; SIQUEIRA, G. L. de A. de; MAYER, F. M.; MIGUEL, O. G.; ZINI, C. A.; LAZZAROTTO, M. Estudo da Composição dos Óleos Essenciais de três Genótipos de Eucalyptus spp. In: SEMANA DE APERFEIÇOAMENTO EM ENGENHARIA FLORESTAL DA UFPR, 2., 2018, Curitiba. Anais. Curitiba: CIFLOMA, 2018. 4 p.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Florestas. |
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| 15. | | SIQUEIRA, G. L. de A. de; LAZZAROTTO, S. R. da S.; HORNUNG, P. S.; LOURENÇON, T. V.; SILVEIRA, A. C. da; SCHNITZLER, E.; LAZZAROTTO, M. Effect of acid alcoholic solution in waxy maize starch treatment. In: CONGRESSO BRASILEIRO DE ANÁLISE TÉRMICA E CALORIMETRIA, 10.; CONGRESSO PAN AMERICANO DE ANÁLISE TÉRMICA E CALORIMETRIA, 4., 2016, São Paulo. Trabalhos. [S.l.]: ABRATEC, 2016. 4 p. Disponível online.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Florestas. |
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| 16. | | SIQUEIRA, G. L. de A. de; SILVEIRA, A. C. da; LAZZAROTTO, S. R. da S.; GODOY, R. C. B. de; SCHNITZLER, E.; LAZZAROTTO, M. Hydrolysis of the low gelatinization temperature Araucaria angustifolia pine seed starch. Journal of Thermal Analysis and Calorimetry, v. 138, n. 2, p. 1269-1278, Oct. 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Florestas. |
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| 17. | | LAZZAROTTO, S. R. da S.; HORNUNG, P. S.; SIQUEIRA, G. L. de A. de; SILVEIRA, A. C. da; SCHNITZLER, E.; LAZZAROTTO, M. Effect of the KMnO4 treatment on the "pinhão" starch. In: CONGRESSO BRASILEIRO DE ANÁLISE TÉRMICA E CALORIMETRIA, 10.; CONGRESSO PAN AMERICANO DE ANÁLISE TÉRMICA E CALORIMETRIA, 4., 2016, São Paulo. Trabalhos. [S.l.]: ABRATEC, 2016. 4 p. Disponível online.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Florestas. |
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| 18. | | SIQUEIRA, G. L. de A. de; LAZZAROTTU, S. R. da S.; HORNUNG, P. S.; SILVEIRA, A. C. da; BANNACH, G.; SCHNITZLER, E.; LAZZAROTTO, M. Evaluation of double treated starches using thermal tools. In: CONGRESSO BRASILEIRO DE ANÁLISE TÉRMICA E CALORIMETRIA, 10.; CONGRESSO PAN AMERICANO DE ANÁLISE TÉRMICA E CALORIMETRIA, 4., 2016, São Paulo. Trabalhos. [S.l.]: ABRATEC, 2016. 4 p. Disponível online.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Florestas. |
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| 19. | | ZANONI, P. R. S.; SILVEIRA, A. C. da; LIMA, E. A. de; MATTOS, P. P. de; CURTO, R. de A.; MAGALHAES, W. L. E.; LAZZAROTTO, M. Uso dos produtos da araucária: madeira e coprodutos. In: SOUSA, V. A. de; FRITZSONS, E.; PINTO JUNIOR, J. E.; AGUIAR, A. V. de (ed.). Araucária: pesquisa e desenvolvimento no Brasil. Brasília, DF: Embrapa, 2021. cap. 17, p. 337-360.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Florestas. |
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| 20. | | HORNUNG, P. S.; SILVEIRA, A. C. da; LAZZAROTTO, S. R. da S.; SIQUEIRA, G. L. de A. de; SCHNITZLER, E.; RIBANI, R. H.; LAZZAROTTO, M. Thermogravimetric alterations of cassava starch granules induced by hydrogen peroxide, UV rays and microwave. In: CONGRESSO BRASILEIRO DE ANÁLISE TÉRMICA E CALORIMETRIA, 10.; CONGRESSO PAN AMERICANO DE ANÁLISE TÉRMICA E CALORIMETRIA, 4., 2016, São Paulo. Trabalhos. [S.l.]: ABRATEC, 2016. 4 p. Disponível online.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Florestas. |
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| Registros recuperados : 22 | |
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