| |
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Gado de Leite. |
|
Data corrente: |
11/08/2021 |
|
Data da última atualização: |
11/08/2021 |
|
Tipo da produção científica: |
Nota Técnica/Nota Científica |
|
Autoria: |
FONSECA, M. D. M.; MAIA, J. M. S.; VARAGO, F. C.; GERN, J. C.; CARVALHO, W. A.; SILVA, S. R.; MOSQUEIRA, V. C. F.; BRANDAO, H. de M.; GUIMARÃES, A. S. |
|
Afiliação: |
Universidade Federal de Lavras; Universidade Federal de Lavras; JULIANA CARINE GERN, CNPGL; WANESSA ARAUJO CARVALHO, CNPGL; Universidade Federal de Ouro Preto; Universidade Federal de Ouro Preto; HUMBERTO DE MELLO BRANDAO, CNPGL; ALESSANDRO DE SA GUIMARAES, CNPGL. |
|
Título: |
Cloxacillin nanostructured formulation for the treatment of bovine keratoconjunctivitis. |
|
Ano de publicação: |
2020 |
|
Fonte/Imprenta: |
Veterinary and Animal Science, v. 9, 100089, 2020. |
|
DOI: |
https://doi.org/10.1016/j.vas.2020.100089 |
|
Idioma: |
Inglês |
|
Notas: |
Short communication. |
|
Conteúdo: |
Infectious bovine keratoconjunctivitis (IBK) is a widespread, contagious ocular disease that affects cattle, especially dairy breeds. The disease is caused by Gram-negative bacteria mainly Moraxella bovis, and its treatment consists of parenteral or topic antibiotic therapy. The topic treatment approach is used more commonly in lactating cows, to avoid milk disposal. However, treatment failures are common, because the antibiotic is removed during lacrimation. This study aimed to evaluate the susceptibility of commercial cloxacillin and evaluate the efficacy of nanostructured cloxacillin in clinical cases of IBK by Moraxella. The minimum inhibitory concentration (MIC) of nanoparticle cloxacillin nanocoated, the nanoparticle without the antibiotic and the commercial cloxacillin were determined in vitro with field samples of Moraxella ovis (5) and Moraxella bovis (5). The efficiency of nanoparticles was tested in three cows naturally infected that were treated with 1.0 mL (with 0.32 mg of nanostructured cloxacillin) for the ocular route. Moraxella bovis was isolated and identified by biochemical and molecular methods before the treatment. The animals were treated every 12 h for six days. The cure was considered by the absence of clinical symptoms and bacteria after treatment. The mucoadhesive nanoparticlebased formulation promoted clinical cure with a low number of doses of antibiotics, probably due to the maintenance of the MIC in the ocular mucosa for longer due to the mucoadhesive characteristics of the nanoparticle. The results indicate that the use of nanocoated cloxacillin is possible to control infectious bovine keratoconjunctivitis. MenosInfectious bovine keratoconjunctivitis (IBK) is a widespread, contagious ocular disease that affects cattle, especially dairy breeds. The disease is caused by Gram-negative bacteria mainly Moraxella bovis, and its treatment consists of parenteral or topic antibiotic therapy. The topic treatment approach is used more commonly in lactating cows, to avoid milk disposal. However, treatment failures are common, because the antibiotic is removed during lacrimation. This study aimed to evaluate the susceptibility of commercial cloxacillin and evaluate the efficacy of nanostructured cloxacillin in clinical cases of IBK by Moraxella. The minimum inhibitory concentration (MIC) of nanoparticle cloxacillin nanocoated, the nanoparticle without the antibiotic and the commercial cloxacillin were determined in vitro with field samples of Moraxella ovis (5) and Moraxella bovis (5). The efficiency of nanoparticles was tested in three cows naturally infected that were treated with 1.0 mL (with 0.32 mg of nanostructured cloxacillin) for the ocular route. Moraxella bovis was isolated and identified by biochemical and molecular methods before the treatment. The animals were treated every 12 h for six days. The cure was considered by the absence of clinical symptoms and bacteria after treatment. The mucoadhesive nanoparticlebased formulation promoted clinical cure with a low number of doses of antibiotics, probably due to the maintenance of the MIC in the ocular mucosa for longer due to the mucoad... Mostrar Tudo |
|
Palavras-Chave: |
Ceratoconjuntivite; Cloxacilina; Nanoestrutura; Nanopartícula mucoadesiva. |
|
Thesagro: |
Bovino; Doença Animal; Moraxella Bovis. |
|
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
|
Marc: |
LEADER 02630naa a2200325 a 4500
001 2133453
005 2021-08-11
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.vas.2020.100089$2DOI
100 1 $aFONSECA, M. D. M.
245 $aCloxacillin nanostructured formulation for the treatment of bovine keratoconjunctivitis.$h[electronic resource]
260 $c2020
500 $aShort communication.
520 $aInfectious bovine keratoconjunctivitis (IBK) is a widespread, contagious ocular disease that affects cattle, especially dairy breeds. The disease is caused by Gram-negative bacteria mainly Moraxella bovis, and its treatment consists of parenteral or topic antibiotic therapy. The topic treatment approach is used more commonly in lactating cows, to avoid milk disposal. However, treatment failures are common, because the antibiotic is removed during lacrimation. This study aimed to evaluate the susceptibility of commercial cloxacillin and evaluate the efficacy of nanostructured cloxacillin in clinical cases of IBK by Moraxella. The minimum inhibitory concentration (MIC) of nanoparticle cloxacillin nanocoated, the nanoparticle without the antibiotic and the commercial cloxacillin were determined in vitro with field samples of Moraxella ovis (5) and Moraxella bovis (5). The efficiency of nanoparticles was tested in three cows naturally infected that were treated with 1.0 mL (with 0.32 mg of nanostructured cloxacillin) for the ocular route. Moraxella bovis was isolated and identified by biochemical and molecular methods before the treatment. The animals were treated every 12 h for six days. The cure was considered by the absence of clinical symptoms and bacteria after treatment. The mucoadhesive nanoparticlebased formulation promoted clinical cure with a low number of doses of antibiotics, probably due to the maintenance of the MIC in the ocular mucosa for longer due to the mucoadhesive characteristics of the nanoparticle. The results indicate that the use of nanocoated cloxacillin is possible to control infectious bovine keratoconjunctivitis.
650 $aBovino
650 $aDoença Animal
650 $aMoraxella Bovis
653 $aCeratoconjuntivite
653 $aCloxacilina
653 $aNanoestrutura
653 $aNanopartícula mucoadesiva
700 1 $aMAIA, J. M. S.
700 1 $aVARAGO, F. C.
700 1 $aGERN, J. C.
700 1 $aCARVALHO, W. A.
700 1 $aSILVA, S. R.
700 1 $aMOSQUEIRA, V. C. F.
700 1 $aBRANDAO, H. de M.
700 1 $aGUIMARÃES, A. S.
773 $tVeterinary and Animal Science$gv. 9, 100089, 2020.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Gado de Leite (CNPGL) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
Registro Completo
|
Biblioteca(s): |
Embrapa Amazônia Ocidental; Embrapa Semiárido; Embrapa Unidades Centrais. |
|
Data corrente: |
21/05/2020 |
|
Data da última atualização: |
20/04/2021 |
|
Tipo da produção científica: |
Autoria/Organização/Edição de Livros |
|
Autoria: |
COSTA, P. da; COSTA, J. R. da; WANDELLI, E. V.; BIANCHINI, F.; TAVARES, E. D. (ed.). |
|
Afiliação: |
PATRICIA DA COSTA, CNPMA; JOANNE REGIS DA COSTA, CPAA; ELISA VIEIRA WANDELLI, CPAA; FABRICIO BIANCHINI, CPATSA; EDSON DIOGO TAVARES, CPATC. |
|
Título: |
No poverty: contributions of Embrapa. |
|
Título original: |
Erradicação da pobreza: contribuições da Embrapa |
|
Ano de publicação: |
2020 |
|
Fonte/Imprenta: |
Brasília, DF: Embrapa, 2020. |
|
Descrição Física: |
E-book (pdf). |
|
Série: |
(Sustainable development goal, 1). |
|
ISBN: |
978-65-86056-03-7 |
|
Idioma: |
Inglês |
|
Notas: |
Translated by Paulo de Holanda Morais. |
|
Conteúdo: |
Poverty eradication, the focus of this book, is addressed in SDG 1 and considered the greatest challenge to achieve global targets. This SDG aims to end poverty in all its forms everywhere. This publication is on the contributions of Embrapa related to SDG targets 1.1, 1.2, and 1.5, understanding that poverty should not only be seen as a deprivation of financial resources, but also, to a large extent, the deprivation of resources, capacities, choices, security, and power. |
|
Palavras-Chave: |
Desigualdade social; ODS. |
|
Thesagro: |
Agricultura Familiar; Biomassa; Desenvolvimento Sustentável; Erradicação; Pobreza; Zoneamento Agrícola. |
|
Thesaurus NAL: |
Family farms; Poverty; Social inequality; Sustainable development. |
|
Categoria do assunto: |
--
B Sociologia Rural |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/213179/1/No-poverty.pdf
|
|
Marc: |
LEADER 01511nam a2200361 a 4500
001 2122498
005 2021-04-20
008 2020 bl uuuu 00u1 u #d
020 $a978-65-86056-03-7
100 1 $aCOSTA, P. da
240 $aErradicação da pobreza: contribuições da Embrapa
245 $aNo poverty$bcontributions of Embrapa.$h[electronic resource]
260 $aBrasília, DF: Embrapa$c2020
300 $cE-book (pdf).
490 $a(Sustainable development goal, 1).
500 $aTranslated by Paulo de Holanda Morais.
520 $aPoverty eradication, the focus of this book, is addressed in SDG 1 and considered the greatest challenge to achieve global targets. This SDG aims to end poverty in all its forms everywhere. This publication is on the contributions of Embrapa related to SDG targets 1.1, 1.2, and 1.5, understanding that poverty should not only be seen as a deprivation of financial resources, but also, to a large extent, the deprivation of resources, capacities, choices, security, and power.
650 $aFamily farms
650 $aPoverty
650 $aSocial inequality
650 $aSustainable development
650 $aAgricultura Familiar
650 $aBiomassa
650 $aDesenvolvimento Sustentável
650 $aErradicação
650 $aPobreza
650 $aZoneamento Agrícola
653 $aDesigualdade social
653 $aODS
700 1 $aCOSTA, J. R. da
700 1 $aWANDELLI, E. V.
700 1 $aBIANCHINI, F.
700 1 $aTAVARES, E. D.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Unidades Centrais (AI-SEDE) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Expressão de busca inválida. Verifique!!! |
|
|
