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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
09/11/2017 |
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Data da última atualização: |
21/11/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVA, I. C. da; MAGALHAES, P. M. de; SOUSA, I. M. de O.; FOGLIO, M. A.; LEONARDECZ, E.; ESTEVES, S. N.; CHAGAS, A. C. de S. |
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Afiliação: |
Ives Charlie da Silva, UNESP; Pedro Melillo de Magalhães, UNICAMP; Ilza Maria de Oliveira Sousa, UNICAMP; Mary Ann Foglio, UNICAMP; Eduardo Leonardecz, UFSCar; SERGIO NOVITA ESTEVES, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE. |
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Título: |
Anthelmintic activity of Artemisia annua in sheepmodel. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of Medicinal Plants Research, v. 11, n. 7, p. 137-143, 2017. |
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DOI: |
10.5897/JMPR2016.6318 |
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Idioma: |
Inglês |
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Conteúdo: |
Artemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), mainly from day 21 post treatment (47.1 and 25.2%, respectively). At the highest dose, the animals avoided eating due to the compound?s bitter taste. It is concluded that A. annua presents moderate anthelmintic activity in sheep in both doses. The lowest dose was accepted by animals and seems to have practical use. Oral administration was safe and after further in vivo trials could be introduced in organic farms in tropical countries. MenosArtemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), m... Mostrar Tudo |
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Thesaurus Nal: |
artemisinin; gastrointestinal nematodes; sesquiterpenoids. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02655naa a2200241 a 4500
001 2079284
005 2017-11-21
008 2017 bl uuuu u00u1 u #d
024 7 $a10.5897/JMPR2016.6318$2DOI
100 1 $aSILVA, I. C. da
245 $aAnthelmintic activity of Artemisia annua in sheepmodel.$h[electronic resource]
260 $c2017
520 $aArtemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), mainly from day 21 post treatment (47.1 and 25.2%, respectively). At the highest dose, the animals avoided eating due to the compound?s bitter taste. It is concluded that A. annua presents moderate anthelmintic activity in sheep in both doses. The lowest dose was accepted by animals and seems to have practical use. Oral administration was safe and after further in vivo trials could be introduced in organic farms in tropical countries.
650 $aartemisinin
650 $agastrointestinal nematodes
650 $asesquiterpenoids
700 1 $aMAGALHAES, P. M. de
700 1 $aSOUSA, I. M. de O.
700 1 $aFOGLIO, M. A.
700 1 $aLEONARDECZ, E.
700 1 $aESTEVES, S. N.
700 1 $aCHAGAS, A. C. de S.
773 $tJournal of Medicinal Plants Research$gv. 11, n. 7, p. 137-143, 2017.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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| Registros recuperados : 13 | |
| 1. |  | OLIVEIRA, C. M. de; FERRACINI, V. L.; FOGLIO, M. A.; MEIJERE, A. de; MARSAIOLI, A. J. Detection, synthesis and absolute configuration of (+)-nortaylorine, a new terpene from Artemisia annua. Tetrahedron, Asymmetry, v.8, n.11, p.1833-1839, 1997.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 3. | | SILVA, I. C. da; FEITOSA, K. A.; FOGLIO, M. A.; MAGALHÃES, P. M.; SOARES, V. E.; OLIVEIRA, G. P. de; CHAGAS, A. C. de S. Avaliação antiparasitária de Artemisia annua L. (Asteraceae) sobre o carrapato Rhipicephalus (Boophilus) microplus (Canestri, 1887) (ACARI: IXODEDAE) em bovinos sob infestação natural. In: CONGRESSO BRASILEIRO DE PARASITOLOGIA VETERINÁRIA, 17., 2012, São Luis. Parasitologia veterinária, bem estar e produção animal: anais. São Luis: Colégio Brasileiro de Parasitologia Veterinária, 2012. p. 160. Resumo PA30.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 4. | | SILVA, I. C. da; MAGALHAES, P. M. de; SOUSA, I. M. de O.; FOGLIO, M. A.; LEONARDECZ, E.; ESTEVES, S. N.; CHAGAS, A. C. de S. Anthelmintic activity of Artemisia annua in sheepmodel. Journal of Medicinal Plants Research, v. 11, n. 7, p. 137-143, 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 5. | | CHARLIE-SILVA, I.; GIGLIOTI, R.; MAGALHÃES, P. M.; SOUSA, I. M. O.; FOGLIO, M. A.; OLIVEIRA, M. C. de S.; CHAGAS, A. C. de S. Lack of impact of dietary inclusion of dried Artemisia annua leaves for cattle on infestation by Rhipicephalus (Boophilus) microplus ticks. Ticks and Tick-borne Diseases, v.9, p. 1115-1119, 2018.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 7. | | CHAGAS, A. C. de S.; GEORGETTI, C. S.; CARVALHO, C. O. de; OLIVEIRA, M. C. de S.; RODRIGUES, R. A.; FOGLIO, M. A.; MAGALHÃES, P. M. DE. In vitro activity of Artemisia annua L (Asteraceae) extracts against Rhipicephalus (Boophilus) microplus. Revista Brasileira de Parasitologia e Veterinária, Jaboticabal, v. 20, n. 1, p. 31-35, jan.-mar. 2011.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 8. | | CHAGAS, A. C. de S.; RODRIGUES, R. A.; FOGLIO, M. A.; MAGALHÃES, J. M.; OLIVEIRA, M. C. de S.; ESTEVES, S. N.; FERREIRA, J. F. S.; GONZALEZ, J. M. Avaliação da atividade de extratos de artemisia annua no controle de Haemonchus contortus em ovinos infectados artificialmente In: CONGRESSO BRASILEIRO DE PARASITOLOGIA VETERINÁRIA, 16., Campo Grande. Anais... Campo Grqande: CBPV, 2010.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 9. | | CHAGAS, A. C. de S.; RODRIGUES, R. A. F.; CARVALHO, C. O.; GIGLIOTI, R.; FOGLIO, M. A.; RUIZ, A. L. T. G.; ESTEVES, S. N.; OLIVEIRA, M. C. de S.; AMARANTE, A. F. T. Avaliação da técnica de microencapsulamento do óleo de eucalipto no desenvolvimento de formulações vermífugas para o controle de nematóides gastrintestinais de ovinos. In: SIMPÓSIO SOBRE INOVAÇÃO E CRIATIVIDADE CIENTÍFICA NA EMBRAPA, 2., 2010, Brasília. Anais... Brasília: Embrapa, 2010.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 10. | | CALA, A. C.; FERREIRA, J. F. S; CHAGAS, A. C. de S.; GONZALEZ, J. M.; RODRIGUES, R. F.; FOGLIO, M. A.; OLIVEIRA, M. C. de S.; SOUSA, I. M.; MAGALHÃES, P. M.; BARIONI JUNIOR, W. Anthelmintic activity of Artemisia annua L. extracts in vitro and the effect of an aqueous extract and artemisinin in sheep naturally infected with gastrointestinal nematodes. Parasitology Research, v. 113, n. 6, p. 2345-2353, jun. 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 11. | | CHAGAS, A. C. de S.; OLIVEIRA, M. C. de S.; ALENCAR, M. M. de; ESTEVES, S. N.; FREITAS, A. R. de; BARROS, A. T. M. de; BRITO, L. G.; VIEIRA, L. C.; HASSUM, I. C.; BRANDAO, H. de M.; CHAVES, F. C. M.; BIZZO, H. R.; MOLENTO, M. B.; KATIKI, L. M.; SILVA, M. F. F. da; CORRÊA, A. G.; FURLAN, M.; FOGLIO, M. A.; RODRIGUES, R. A. F.; CARVALHO, J. E.; REHDER, V. L. G. Pesquisa de compostos bioativos vegetais para o controle de parasitas de ruminantes. In: SIMPÓSIO EMBRAPA LABEX DE SANIDADE ANIMAL, 1., 2009, Campo Grande. Anais... Campo Grande: Embrapa Gado de Corte, 2009. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 12. | | CHAGAS, A. C. de S.; OLIVEIRA, M. C. de S.; ALENCAR, M. M. de; ESTEVES, S. N.; FREITAS, A. R. de; BARROS, A. T. M. de; BRITO, L. G.; VIEIRA, L. C.; HASSUM, I. C.; BRANDAO, H. de M.; CHAVES, F. C. M.; BIZZO, H. R.; MOLENTO, M. B.; KATIKI, L. M.; SILVA, M. F. F. da; CORRÊA, A. G.; FURLAN, M.; FOGLIO, M. A.; RODRIGUES, R. A. F.; CARVALHO, J. E.; REHDER, V. L. G. Pesquisa de compostos bioativos vegetais para o controle de parasitas de ruminantes. In: SIMPÓSIO EMBRAPA LABEX DE SANIDADE ANIMAL, 1., 2009, Campo Grande. Anais... Campo Grande: Embrapa Gado de Corte, 2009. 1 CD-ROM| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 13. | | CHAGAS, A. C. de S.; OLIVEIRA, M. C. de S.; ALENCAR, M. M. de; ESTEVES, S. N.; FREITAS, A. R. de; BARROS, A. T. M. de; BRITO, L. G.; VIEIRA, L. da S.; HASSUM, I. C.; BRANDÃO, H. de M.; CHAVES, F. C. M.; BIZZO, H. R.; MOLENTO, M. B.; KATIKI, L. M.; SILVA, M. F. F. da; CORRÊA, A. G.; FURLAN, M.; FOGLIO, M. A.; RODRIGUES, R. A. F.; CARVALHO, J. E.; REHDER, V. L. G. Pesquisa de compostos bioativos vegetais para o controle de parasitas de ruminantes. In: SIMPÓSIO EMBRAPA LABEX DE SANIDADE ANIMAL, 1., 2009, Campo Grande. Anais... Campo Grande: Embrapa Gado de Corte, 2009. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Rondônia. |
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| Registros recuperados : 13 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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