Data/hora: 03/06/2024 11:19:33

Biblioteca(s): | Embrapa Agroenergia; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Soja.
Data corrente: | 24/05/2021
Data da última atualização: | 02/06/2021
Autoria: | VIEIRA, L. R.; FREITAS, N. C.; JUSTEN, F.; MIRANDA, V. de J.; GARCIA, B. de O.; NEPOMUCENO, A. L.; FUGANTI-PAGLIARINI, R.; FELIPE, M. S. S.; MOLINARI, H. B. C.; VELINI, E. D.; PINTO, E. R. de C.; DAGLI, M. L. Z.; ANDRADE, G.; FERNANDES, P. M. B.; MERTZ-HENNING, L. M.; KOBAYASHI, A. K.
Afiliação: | LETÍCIA RIOS VIEIRA; NATÁLIA CHAGAS FREITAS; FERNANDA JUSTEN; VÍVIAN DE JESUS MIRANDA; BRUNO DE OLIVEIRA GARCIA, Universidade Federal de Lavras; ALEXANDRE LIMA NEPOMUCENO, CNPSO; RENATA FUGANTI-PAGLIARINI; MARIA SUELI SOARES FELIPE, Universidade Católica de Brasília; HUGO BRUNO CORREA MOLINARI, CNPAE; EDIVALDO DOMINGUES VELINI, Universidade Estadual Paulista; EDUARDO ROMANO DE CAMPOS PINTO, Cenargen; MARIA LUCIA ZAIDAN DAGLI, Universidade de São Paulo; GALDINO ANDRADE, Universidade Estatual de Londrina; PATRICIA MACHADO BUENO FERNANDES, Universidade Federal do Espírito Santo; LILIANE MARCIA MERTZ HENNING, CNPSO; ADILSON KENJI KOBAYASHI, CNPAE.
Título: | Regulatory framework of genome editing in Brazil and worldwide.
Ano de publicação: | 2021
Fonte/Imprenta: | In: MOLINARI, H. B. C.; VIEIRA, L. R.; SILVA, N. V. e; PRADO, G. S.; LOPES FILHO, J. F. (Ed.). CRISPR technology in plant genome editing: biotechnology applied to agriculture. Brasília, DF : Embrapa, 2021. Chapter 5, p. 169-195.
Idioma: | Inglês
Conteúdo: | The regulation of the use of products obtained through genome-editing techniques has been the subject of great debate worldwide. Currently, the discussions are mainly focused on whether products obtained by different strategies of site-directed nucleases (SDN) should or not be classified as Genetically Modified Organisms (GMOs). In the SDN-1 application, the natural DNA cell repair pathway (Non-Homologous End-Joining - NHEJ) is explored to introduce simple random mutations (substitutions, insertions, and deletions) by systems such as CRISPR-Cas, TALENs, or Zinc Fingers Nucleases, which cause silencing of the gene product after breaking DNA (by Double-Strand Break - DSB). In the SDN-2 approach, a template DNA is also used to introduce a change in the sequence of nitrogen bases (A, C, G, T) at the target site where the DSB occurred, exploring another natural repair system directed by a DNA fragment from the same species (Homology-Directed Repair - HDR). In the SDN-3 approach, both NHEJ and HDR can be explored to insert one or more DNA fragments with sequences necessary for the expression of a gene (promoter, coding, and terminator region) at a specific location in the genome. In the following topics, questions related to genome editing regulation in different countries are discussed in detail.
Thesagro: | Biotecnologia; DNA; Engenharia Genética; Genética Vegetal; Legislação.
Thesaurus Nal: | Biotechnology; Genetic engineering; Genetically modified organisms; Plant genetics.
Categoria do assunto: | G Melhoramento Genético
URL: | http://ainfo.cnptia.embrapa.br/digital/bitstream/item/223607/1/Regulatory-framework-of-genome-CAP-5.pdf
Registro original: | Embrapa Soja (CNPSO)

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CNPAE - (3870-1) - UPE - PL - DD -  -  -  - DIS
CENARGEN - (38540-1) - UPC - PL - DD -  -  -  - DIS
CNPSO - (40212-1) - UPC - PL - DD -  -  -  - DIS