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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pantanal. Para informações adicionais entre em contato com cpap.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pantanal. |
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Data corrente: |
17/07/2014 |
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Data da última atualização: |
19/05/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BORSATO, D. M.; PRUDENTE, A. S.; DOLL-BOSCARDIN, P. M.; BORSATO, A. V.; LUZ, C. F. P.; MAIA, B. H. L. N. S.; CABRINI, D. A.; OTUKI, M. F.; MIGUEL, M. D.; FARAGO, P. V.; MIGUEL, O. G. |
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Afiliação: |
DÉBORA M. BORSATO, UFPR; ARTHUR S. PRUDENTE, UFPR; PATRÍCIA M. DOLL BOSCARDIN, UEPG; AURELIO VINICIUS BORSATO, CPAP; CYNTHIA F. P. LUZ, INSTITUTO DE BOTÂNICA; BEATRIZ H. L. N. S. MAIA, UFPR; DANIELA A. CABRINI, UFPR; MICHEL F. OTUKI, UEPG; MARILIS D. MIGUEL, UFPR; PAULO V. FARAGO, UEPG; OBDULIO G. MIGUEL, UFPR. |
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Título: |
Topical anti-inflammatory activity of a monofloral honey of Mimosa scabrella provided by Melipona marginata during winter in southern Brazil. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Journal of Medicinal Food, v. 17, n. 7, p. 817-825, 2014. |
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ISSN: |
1096-620X |
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DOI: |
10.1089/jmf.2013.0024 |
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Idioma: |
Inglês |
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Conteúdo: |
Melipona marginata is an endangered species of stingless bee from Brazil that produces honey with particular physicochemical features and a remarkable exotic flavor. To the best of our knowledge, this is the first report devoted to exploring the medicinal potential of this honey. Thus, the aim of this paper was to investigate the potential anti-inflammatory activity of honey extract from M. marginata on skin inflammation. The honey sample was classified as a monofloral honey of Mimosa scabrella. The presence of 11 phenolic compounds as kaempferol and caffeic acid was detected using the highperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-UV-ESI-MS) method. The anti-inflammatory activity was measured using a 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model of inflammation in mice. The topical application of the M. marginata honey extract (1.0 mg/ear) was able to reduce ear edema with an inhibitory effect of 54 ? 5%. This extract decreased the myeloperoxidase activity in 75 ? 3%, which suggests a lower leucocyte infiltration that was confirmed by histological analysis. This extract also provided a reduction of 55 ? 14% in the production of reactive oxygen species. This anti-inflammatory activity could be due to a synergic effect of the phenolic compounds identified in the honey sample. Taken together, these results open up new possibilities for the use of M. marginata honey extract in skin disorders. |
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Palavras-Chave: |
Ear edema; HPLC-UV-ESI-MS analysis; Monofloral honey; Pollen analysis; Stingless bee. |
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Thesagro: |
Mimosa Scabrella. |
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Thesaurus Nal: |
phenolic compounds. |
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Categoria do assunto: |
-- |
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Marc: |
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100 1 $aBORSATO, D. M.
245 $aTopical anti-inflammatory activity of a monofloral honey of Mimosa scabrella provided by Melipona marginata during winter in southern Brazil.
260 $c2014
520 $aMelipona marginata is an endangered species of stingless bee from Brazil that produces honey with particular physicochemical features and a remarkable exotic flavor. To the best of our knowledge, this is the first report devoted to exploring the medicinal potential of this honey. Thus, the aim of this paper was to investigate the potential anti-inflammatory activity of honey extract from M. marginata on skin inflammation. The honey sample was classified as a monofloral honey of Mimosa scabrella. The presence of 11 phenolic compounds as kaempferol and caffeic acid was detected using the highperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-UV-ESI-MS) method. The anti-inflammatory activity was measured using a 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model of inflammation in mice. The topical application of the M. marginata honey extract (1.0 mg/ear) was able to reduce ear edema with an inhibitory effect of 54 ? 5%. This extract decreased the myeloperoxidase activity in 75 ? 3%, which suggests a lower leucocyte infiltration that was confirmed by histological analysis. This extract also provided a reduction of 55 ? 14% in the production of reactive oxygen species. This anti-inflammatory activity could be due to a synergic effect of the phenolic compounds identified in the honey sample. Taken together, these results open up new possibilities for the use of M. marginata honey extract in skin disorders.
650 $aphenolic compounds
650 $aMimosa Scabrella
653 $aEar edema
653 $aHPLC-UV-ESI-MS analysis
653 $aMonofloral honey
653 $aPollen analysis
653 $aStingless bee
700 1 $aPRUDENTE, A. S.
700 1 $aDOLL-BOSCARDIN, P. M.
700 1 $aBORSATO, A. V.
700 1 $aLUZ, C. F. P.
700 1 $aMAIA, B. H. L. N. S.
700 1 $aCABRINI, D. A.
700 1 $aOTUKI, M. F.
700 1 $aMIGUEL, M. D.
700 1 $aFARAGO, P. V.
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773 $tJournal of Medicinal Food$gv. 17, n. 7, p. 817-825, 2014.
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Embrapa Pantanal (CPAP) |
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| 1. |  | RIBEIRO, A. C. C. L. Manejo sanitário do rebanho leiteiro. In: TORRES, R. A.; PIRES, J. A. A. (ed.). Estratégias de manejo visando a melhoria da pecuária de leite familiar do Norte de Minas e do Vale do Jequitinhonha. Juiz de Fora: Embrapa Gado de Leite, 2008. p. 91-98.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 8. | | LEITE, R. C.; HADAD, J. P.; COSTA, G. M.; PELLEGRIN, A. O.; RIBEIRO, A. C. C. L. Tecnica modificada para coleta de lavado prepucial de touros, para exame de Trichomonose e ou Campilobacteriose. In: CONGRESSO BRASILEIRO DE REPRODUCAO ANIMAL, 11., 1995, Belo Horizonte. Anais. Belo Horizonte: Colegio Brasileiro de Reproducao Animal, 1995. p.214.| Biblioteca(s): Embrapa Pantanal. |
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| 9. | | CUNHA, A. P.; BELLO, A. C. P. P.; LEITE, R. C.; MELO, M. M.; BRAZ, G. F.; RIBEIRO, A. C. C. L.; OLIVEIRA, P. R. Avaliação de parâmetros clínicos e hematológicos de equinos submetidos a um programa de controle estratégico de Amblyomma cajennense (Fabricius, 1787) (Acari: ixodidae). Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Belo Horizonte, v. 60, n. 1, p. 113-120, 2008.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 10. | | SOUZA, R. C.; LOPES, F. C. F.; REIS, R. B.; DEMEU, A. A.; VERNEQUE, R. S.; RIBEIRO, A. C. C. L.; BARBOSA, F. A. Parâmetros de fermentação ruminal de vacas Holândes x zebu em lactação alimentadas com dietas à base de cana de açúcar, suplementadas com níveis crescentes de uréia e sulfato de amônio. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA. 45., 2008, Lavras, MG. Anais... Lavras: SBZ / UFLA, 2008. 1 CD| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 10 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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