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Registro Completo |
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
10/07/2017 |
Data da última atualização: |
10/07/2017 |
Autoria: |
ELLIS, D. |
Título: |
The effects of external cations and ouabain on the intracellular sodium activity of sheep heart Purkinje fibres. |
Ano de publicação: |
1977 |
Fonte/Imprenta: |
The Journal of Physiology, v. 273, n. 1, p. 211-240, Dec. 1977. |
Idioma: |
Inglês |
Conteúdo: |
Abstract: 1. The intracellular Na activity of sheep heart Purkinje fibres has been measured using recessed-tip Na(+)-sensitive glass micro-electrodes.2. The internal Na activity was 7.2 +/- 2.0 mM (mean +/- S.D., n = 32) at the normal external Na concentration, [Na](o), in these experiments of 140 mM (equivalent to an external Na activity of 105 mM). The equilibrium potential for Na across the fibre membrane was therefore approximately + 70 mV.3. When the [K](o) was altered the internal Na activity changed, reaching a new level within about 20 min. Increasing the [K](o) from 4 to 25 mM decreased the internal Na by approximately 30%, while decreasing the [K](o) from 4 to 1 mM increased internal Na by 20%.4. The removal of external K produced an easily reversible increase in the internal Na with an initial rate equivalent to a concentration change of 0.24 +/- 0.07 m-mole/min (mean +/- S.D., n = 8).5. Ouabain produced increases in the internal Na activity that were only very slowly reversible. The threshold concentration for producing an increase was approximately 10(-7)M.6. When [Na](o) was reduced the internal Na activity fell rapidly with a single exponential time course (time constant 3.3 +/- 0.8 min, mean +/- S.D., n = 16) to a new, relatively stable level. The recovery of internal Na on return to the normal [Na](o) did not have a simple time course. It was normally complete within 10-30 min.7. The relationship of the stabilized level of the internal Na activity to the [Na](o) was approximately linear over the range 140-14 mM-[Na](o). When [Na](o) was reduced from 140 to 14 mM the internal Na activity fell by 72 +/- 5% (mean +/- S.D., n = 21).8. When the [Na](o) was reduced, the decrease in the internal Na activity was partially inhibited by Mn or by removal external Ca.9. When the [Ca](o) was altered over the range 0.2-16 mM the internal Na activity was reduced by approximately 50% for a tenfold increase in the [Ca](o).10. The relationship between internal Na and contractility is discussed. MenosAbstract: 1. The intracellular Na activity of sheep heart Purkinje fibres has been measured using recessed-tip Na(+)-sensitive glass micro-electrodes.2. The internal Na activity was 7.2 +/- 2.0 mM (mean +/- S.D., n = 32) at the normal external Na concentration, [Na](o), in these experiments of 140 mM (equivalent to an external Na activity of 105 mM). The equilibrium potential for Na across the fibre membrane was therefore approximately + 70 mV.3. When the [K](o) was altered the internal Na activity changed, reaching a new level within about 20 min. Increasing the [K](o) from 4 to 25 mM decreased the internal Na by approximately 30%, while decreasing the [K](o) from 4 to 1 mM increased internal Na by 20%.4. The removal of external K produced an easily reversible increase in the internal Na with an initial rate equivalent to a concentration change of 0.24 +/- 0.07 m-mole/min (mean +/- S.D., n = 8).5. Ouabain produced increases in the internal Na activity that were only very slowly reversible. The threshold concentration for producing an increase was approximately 10(-7)M.6. When [Na](o) was reduced the internal Na activity fell rapidly with a single exponential time course (time constant 3.3 +/- 0.8 min, mean +/- S.D., n = 16) to a new, relatively stable level. The recovery of internal Na on return to the normal [Na](o) did not have a simple time course. It was normally complete within 10-30 min.7. The relationship of the stabilized level of the internal Na activity to the [Na... Mostrar Tudo |
Palavras-Chave: |
Drug effects; Heart Conduction System; Purkinje Fibers. |
Thesaurus Nal: |
Calcium; Manganese; Metabolism; Pharmacology; Physiology; Potassium; Sheep; Sodium. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02728naa a2200253 a 4500 001 2072435 005 2017-07-10 008 1977 bl uuuu u00u1 u #d 100 1 $aELLIS, D. 245 $aThe effects of external cations and ouabain on the intracellular sodium activity of sheep heart Purkinje fibres. 260 $c1977 520 $aAbstract: 1. The intracellular Na activity of sheep heart Purkinje fibres has been measured using recessed-tip Na(+)-sensitive glass micro-electrodes.2. The internal Na activity was 7.2 +/- 2.0 mM (mean +/- S.D., n = 32) at the normal external Na concentration, [Na](o), in these experiments of 140 mM (equivalent to an external Na activity of 105 mM). The equilibrium potential for Na across the fibre membrane was therefore approximately + 70 mV.3. When the [K](o) was altered the internal Na activity changed, reaching a new level within about 20 min. Increasing the [K](o) from 4 to 25 mM decreased the internal Na by approximately 30%, while decreasing the [K](o) from 4 to 1 mM increased internal Na by 20%.4. The removal of external K produced an easily reversible increase in the internal Na with an initial rate equivalent to a concentration change of 0.24 +/- 0.07 m-mole/min (mean +/- S.D., n = 8).5. Ouabain produced increases in the internal Na activity that were only very slowly reversible. The threshold concentration for producing an increase was approximately 10(-7)M.6. When [Na](o) was reduced the internal Na activity fell rapidly with a single exponential time course (time constant 3.3 +/- 0.8 min, mean +/- S.D., n = 16) to a new, relatively stable level. The recovery of internal Na on return to the normal [Na](o) did not have a simple time course. It was normally complete within 10-30 min.7. The relationship of the stabilized level of the internal Na activity to the [Na](o) was approximately linear over the range 140-14 mM-[Na](o). When [Na](o) was reduced from 140 to 14 mM the internal Na activity fell by 72 +/- 5% (mean +/- S.D., n = 21).8. When the [Na](o) was reduced, the decrease in the internal Na activity was partially inhibited by Mn or by removal external Ca.9. When the [Ca](o) was altered over the range 0.2-16 mM the internal Na activity was reduced by approximately 50% for a tenfold increase in the [Ca](o).10. The relationship between internal Na and contractility is discussed. 650 $aCalcium 650 $aManganese 650 $aMetabolism 650 $aPharmacology 650 $aPhysiology 650 $aPotassium 650 $aSheep 650 $aSodium 653 $aDrug effects 653 $aHeart Conduction System 653 $aPurkinje Fibers 773 $tThe Journal of Physiology$gv. 273, n. 1, p. 211-240, Dec. 1977.
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Embrapa Caprinos e Ovinos (CNPC) |
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5. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | RODRIGUES, L.; ALVES, A. A. C.; PAIVA, L.; PAIVA, R.; ELLIS, D.; JENDEREK, M. Evaluation of cryogenic procedures for cryopreservation of cassava genotypes. In: ASA-CSSA-SSSA INTERNATIONAL ANNUAL MEETINGS, 2011, San Antonio. Fundamental for life: soil, crop, and environmental sciences: abstracts. Madison: ASA: CSSA: SSSA, 2011. Anais web.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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8. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | KAYA, E.; ALVES, A. A. C.; RODRIGUES, L.; JENDEREK, M.; HERNANDEZ-ELLIS, M.; OZUDOGRU, A.; ELLIS, D. Cryopreservation of eucalyptus genetic resources. Cryo-Letters, v. 34, n.6, p.608-618, 2013.Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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9. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | SOUZA, F. V. D.; KAYA, E.; VIEIRA, L. de J.; SOUZA, A. da S.; CARVALHO, M. de J. da S.; SANTOS, E. B.; ALVES, A. A. C.; ELLIS, D. Cryopreservation of Hamilin sweet orange [(Citrus sinensis (L.) Osbeck)] embryogenic calli using a modified aluminum cryo-plate technique. Scientia Horticulturae, v.224, p.302-305, October ,2017.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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