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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sul. |
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Data corrente: |
10/05/2011 |
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Data da última atualização: |
04/08/2011 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
STEIBEL, J. P.; BATES, R. O.; ROSA, G. J. M.; TEMPELMAN, R. J.; RILINGTON, V. D.; RAGAVENDRAN, A.; RANEY, NANCY E.; RAMOS, A. M.; CARDOSO, F. F.; EDWARDS, D. B.; ERNST, C. W. |
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Afiliação: |
JUAN PEDRO STEIBEL, Department of Animal Science, Michigan State University; RONALD O. BATES, Department of Animal Science, Michigan State University; GUILHERME J. M. ROSA, Department of Animal Sciences, University of Wisconsin; ROBERT J. TEMPELMAN, Department of Animal Science, Michigan State University; VALENCIA D. RILINGTON, Department of Animal Science, Michigan State University; ASHOK RAGAVENDRAN, Department of Animal Science, Michigan State University; NANCY E. RANEY, Department of Animal Science, Michigan State University; ANTONIO MARCOS RAMOS, Department of Animal Science, Michigan State University; FERNANDO FLORES CARDOSO, CPPSUL; DAVID B. EDWARDS, Department of Animal Science, Michigan State University; ERNST, C. W., Department of Animal Science, Michigan State University. |
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Título: |
Genome-wide linkage analysis of global gene expression in loin muscle tissue identifies candidate genes in pigs. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
PLoS ONE, San Francisco, v. 6, n. 2, e16766, Feb. 2011. |
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Idioma: |
Inglês |
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Conteúdo: |
Background: Nearly 6,000 QTL have been reported for 588 different traits in pigs, more than in any other livestock species. However, this effort has translated into only a few confirmed causative variants. A powerful strategy for revealing candidate genes involves expression QTL (eQTL) mapping, where the mRNA abundance of a set of transcripts is used as the response variable for a QTL scan. Methodology/Principal Findings: We utilized a whole genome expression microarray and an F2 pig resource population to conduct a global eQTL analysis in loin muscle tissue, and compared results to previously inferred phenotypic QTL (pQTL) from the same experimental cross. We found 62 unique eQTL (FDR ,10%) and identified 3 gene networks enriched with genes subject to genetic control involved in lipid metabolism, DNA replication, and cell cycle regulation. We observed strong evidence of local regulation (40 out of 59 eQTL with known genomic position) and compared these eQTL to pQTL to help identify potential candidate genes. Among the interesting associations, we found aldo-keto reductase 7A2 (AKR7A2) and thioredoxin domain containing 12 (TXNDC12) eQTL that are part of a network associated with lipid metabolism and in turn overlap with pQTL regions for marbling, % intramuscular fat (% fat) and loin muscle area on Sus scrofa (SSC) chromosome 6. Additionally, we report 13 genomic regions with overlapping eQTL and pQTL involving 14 local eQTL. Conclusions/Significance: Results of this analysis provide novel candidate genes for important complex pig phenotypes. MenosBackground: Nearly 6,000 QTL have been reported for 588 different traits in pigs, more than in any other livestock species. However, this effort has translated into only a few confirmed causative variants. A powerful strategy for revealing candidate genes involves expression QTL (eQTL) mapping, where the mRNA abundance of a set of transcripts is used as the response variable for a QTL scan. Methodology/Principal Findings: We utilized a whole genome expression microarray and an F2 pig resource population to conduct a global eQTL analysis in loin muscle tissue, and compared results to previously inferred phenotypic QTL (pQTL) from the same experimental cross. We found 62 unique eQTL (FDR ,10%) and identified 3 gene networks enriched with genes subject to genetic control involved in lipid metabolism, DNA replication, and cell cycle regulation. We observed strong evidence of local regulation (40 out of 59 eQTL with known genomic position) and compared these eQTL to pQTL to help identify potential candidate genes. Among the interesting associations, we found aldo-keto reductase 7A2 (AKR7A2) and thioredoxin domain containing 12 (TXNDC12) eQTL that are part of a network associated with lipid metabolism and in turn overlap with pQTL regions for marbling, % intramuscular fat (% fat) and loin muscle area on Sus scrofa (SSC) chromosome 6. Additionally, we report 13 genomic regions with overlapping eQTL and pQTL involving 14 local eQTL. Conclusions/Significance: Results of this analysis... Mostrar Tudo |
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Thesagro: |
Genética; Suíno. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/33973/1/METAS-2011-FFC-Steibel-et-al-2011-PLoS-ONE-62-e16766.pdf
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Marc: |
LEADER 02341naa a2200265 a 4500
001 1888216
005 2011-08-04
008 2011 bl uuuu u00u1 u #d
100 1 $aSTEIBEL, J. P.
245 $aGenome-wide linkage analysis of global gene expression in loin muscle tissue identifies candidate genes in pigs.$h[electronic resource]
260 $c2011
520 $aBackground: Nearly 6,000 QTL have been reported for 588 different traits in pigs, more than in any other livestock species. However, this effort has translated into only a few confirmed causative variants. A powerful strategy for revealing candidate genes involves expression QTL (eQTL) mapping, where the mRNA abundance of a set of transcripts is used as the response variable for a QTL scan. Methodology/Principal Findings: We utilized a whole genome expression microarray and an F2 pig resource population to conduct a global eQTL analysis in loin muscle tissue, and compared results to previously inferred phenotypic QTL (pQTL) from the same experimental cross. We found 62 unique eQTL (FDR ,10%) and identified 3 gene networks enriched with genes subject to genetic control involved in lipid metabolism, DNA replication, and cell cycle regulation. We observed strong evidence of local regulation (40 out of 59 eQTL with known genomic position) and compared these eQTL to pQTL to help identify potential candidate genes. Among the interesting associations, we found aldo-keto reductase 7A2 (AKR7A2) and thioredoxin domain containing 12 (TXNDC12) eQTL that are part of a network associated with lipid metabolism and in turn overlap with pQTL regions for marbling, % intramuscular fat (% fat) and loin muscle area on Sus scrofa (SSC) chromosome 6. Additionally, we report 13 genomic regions with overlapping eQTL and pQTL involving 14 local eQTL. Conclusions/Significance: Results of this analysis provide novel candidate genes for important complex pig phenotypes.
650 $aGenética
650 $aSuíno
700 1 $aBATES, R. O.
700 1 $aROSA, G. J. M.
700 1 $aTEMPELMAN, R. J.
700 1 $aRILINGTON, V. D.
700 1 $aRAGAVENDRAN, A.
700 1 $aRANEY, NANCY E.
700 1 $aRAMOS, A. M.
700 1 $aCARDOSO, F. F.
700 1 $aEDWARDS, D. B.
700 1 $aERNST, C. W.
773 $tPLoS ONE, San Francisco$gv. 6, n. 2, e16766, Feb. 2011.
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Registro original: |
Embrapa Pecuária Sul (CPPSUL) |
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| Registros recuperados : 394 | |
| 147. |  | BENAVENTE, M.; SILVEIRA, C.; BARBA, C.; CAMACHO, M. E.; SERENO, J. R. B.; DELGADO, J. V. Tecnologia de la conservacion: II. programas "ex situ". Canis et Felis, Madrid, n.47, p.61-68, oct., 2000.| Biblioteca(s): Embrapa Pantanal. |
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| 148. | | BENAVENTE, M.; SILVEIRA, C.; BARBA, C.; CAMACHO, M. E.; SERENO, J. R. B.; DELGADO, J. V. Tecnología de la conservación II: Programas "ex situ". Separata de: Canis et Felis, Madirid, n. 47, p. 61-68, 2000.| Biblioteca(s): Embrapa Pantanal. |
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| 151. | | SERENO, J. R. B.; SERENO, F. T. P. S.; BARBA, C.; CABELLO, A.; DELGADO, J. V. Training of Iberian pigs on mounting ONTO a DUMMY at an artificial insemination programme. In: WORLD CONFERENCE ON ANIMAL PRODUCTION, 9.; REUNIAO DA ASSOCIACAO LATINOAMERICANA DE PRODUCAO ANIMAL, 18., 2003, Porto Alegre. Abstracts. Porto Alegre: [s.n.], 2003. nao paginado. CD-ROM.| Biblioteca(s): Embrapa Pantanal. |
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| 154. | | SERENO, J. R. B.; DELGADO, J. V.; SERENO, F. T. P. S.; BARBA, C.; ALEJANDRO CABELLO, A. Banco de semen das diferentes variedades do suino Iberico. In: REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 41., 2004, Campo Grande-MS. A producao animal e a seguranca alimentar - anais. Campo Grande, MS: SBZ, 2004. CD ROM 3 p.| Biblioteca(s): Embrapa Pantanal. |
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| 155. | | ABREU, U. G.; SANTOS, S. A.; SERENO, J. R. B.; COMASTRI FILHO, J. A.; RAVANELLI, M. S. Avaliacao morfometrica dos bovinos pantaneiros em um nucleo de criacao "in situ". In: CONGRESO IBEROAMERICANO DE RAZAS CRIOLLAS, 6.; SIMPOSIO IBEROAMERICANO SOBRE CONSERVACION Y UTILIZACION DE RECURSOS ZOOGENETICOS, 4., 2003, Recife. Resumenes de Ponencias y Comunicaciones. Recife: FIRC / CYTED, 2003. nao paginado.| Biblioteca(s): Embrapa Pantanal. |
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| 159. | | ABREU, U. G. P. de; COBUCI, J. A.; PIMENTEL, C. M.; SERENO, J. R. B.; LARA, M. A. C. Analise da curva de crescimento da raca de bovino pantaneiro. In: SIMPOSIO DE RECURSOS GENETICOS PARA A AMERICA LATINA E CARIBE - SIRGEALC, 3.; REUNIAO LATINO AMERICANA DE ESPECIALISTAS EM ARACHIS, 3.; REUNIAO LATINO AMERICANA DE ESPECIALISTAS EM RECURSOS GENETICOS FLORESTAIS, 3., 2001, Londrina. Anais... Londrina: IAPAR, 2001. p.465-467.| Biblioteca(s): Embrapa Pantanal. |
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| 160. | | SUAREZ, M. V.; BARBA, C.; FORERO, J.; SERENO, J. R. B.; DIEGUEZ, E.; DELGADO BERMEJO, J. V. Analisis multivariante entre poblaciones porcinas de origen iberico basado en parametros reproductivos. In: SIMPOSIO IBERO-AMERICANO SOBRE CONSERVACAO DE RECURSOS GENETICOS ANIMAIS, 1., 2000, Corumba, MS. Anais... Corumba: Embrapa Pantanal, 2000. p.8.| Biblioteca(s): Embrapa Pantanal. |
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| Registros recuperados : 394 | |
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