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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroenergia. Para informações adicionais entre em contato com cnpae.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroenergia. |
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Data corrente: |
19/04/2021 |
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Data da última atualização: |
20/04/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVÉRIO NETO, W.; DUTRA, G. V. S.; BRITO NETA, M. de S.; CHAVES, S. B.; VALADARES, L. F.; SOUZA JÚNIOR, F. G. de; MACHADO, F. |
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Afiliação: |
WESLANY SILVÉRIO NETO, Universidade de Brasília; GABRIEL VICTOR SIMÕES DUTRA, Universidade de Brasília; MARIA DE SOUSA BRITO NETA, Universidade de Brasília; SACHA BRAUN CHAVES, Universidade de Brasília; LEONARDO FONSECA VALADARES, CNPAE; FERNANDO GOMES DE SOUZA JÚNIOR, Universidade Federal do Rio de Janeiro; FABRICIO MACHADO, Universidade de Brasília. |
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Título: |
Nanodispersions of magnetic poly(vinyl pivalate) for biomedical applications: Synthesis and in vitro evaluation of its cytotoxicity in cancer cells. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Materials Today Communications, v. 27, 102333, June 2021. |
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Descrição Física: |
il. color. |
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DOI: |
https://doi.org/10.1016/j.mtcomm.2021.102333 |
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Idioma: |
Inglês |
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Conteúdo: |
The development of polymeric nanomaterials, combining properties of polymers and superparamagnetic nanoparticles, has potential for biomedical applications, such as treatment of tumors through intravascular embolization and hyperthermia. Therefore, this work aims at development of a new magnetopolymeric fluid formed by magnetic nanoparticles of iron oxide (Fe3O4) coated with chemically modified oleic acid and which were uniformly dispersed in spherical nanoparticles of poly(vinyl pivalate) through in situ polymerization process via miniemulsion, synthesized using from 5.0 to 20.0 wt% of magnetic oxide in relation to vinyl pivalate content. Samples were characterized by infrared absorption vibration spectroscopy, thermogravimetric analysis, dynamic light scattering, differential scanning calorimetry, X-ray diffraction, transmission electron microscopy, Mössbauer spectroscopy, Raman spectroscopy, vibrating sample magnetometer and magnetic induction heating test. Cytotoxicity was evaluated in vitro in B16F10 melanoma cancer cells, murine mammary adenocarcinoma (4T1-luciferase), NIH-3T3 fibroblast cells and human keratinocytes (HaCat). The magnetopolymeric fluids exhibited maximum conversions of approximately 82 %, hydrodynamic diameter of 180 nm, spherical morphology, preserved superparamagnetic behavior and glass transition temperature ranging from 56.2 to 62.5 °C. Cell viability tests demonstrated that nanocomposites presented low cytotoxicity to tumor and non-tumor cells at concentrations studied. These results suggest potential of magnetopolymeric fluids as an embolic agent for selective and complete obstruction of blood vessels of different sizes and capacity for treatment by hyperthermia. MenosThe development of polymeric nanomaterials, combining properties of polymers and superparamagnetic nanoparticles, has potential for biomedical applications, such as treatment of tumors through intravascular embolization and hyperthermia. Therefore, this work aims at development of a new magnetopolymeric fluid formed by magnetic nanoparticles of iron oxide (Fe3O4) coated with chemically modified oleic acid and which were uniformly dispersed in spherical nanoparticles of poly(vinyl pivalate) through in situ polymerization process via miniemulsion, synthesized using from 5.0 to 20.0 wt% of magnetic oxide in relation to vinyl pivalate content. Samples were characterized by infrared absorption vibration spectroscopy, thermogravimetric analysis, dynamic light scattering, differential scanning calorimetry, X-ray diffraction, transmission electron microscopy, Mössbauer spectroscopy, Raman spectroscopy, vibrating sample magnetometer and magnetic induction heating test. Cytotoxicity was evaluated in vitro in B16F10 melanoma cancer cells, murine mammary adenocarcinoma (4T1-luciferase), NIH-3T3 fibroblast cells and human keratinocytes (HaCat). The magnetopolymeric fluids exhibited maximum conversions of approximately 82 %, hydrodynamic diameter of 180 nm, spherical morphology, preserved superparamagnetic behavior and glass transition temperature ranging from 56.2 to 62.5 °C. Cell viability tests demonstrated that nanocomposites presented low cytotoxicity to tumor and non-tumor cells at ... Mostrar Tudo |
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Palavras-Chave: |
Hyperthermia; Miniemulsion polymerization; Poly(vinyl pivalate); Superparamagnetic nanoparticles; Vascular embolization. |
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Categoria do assunto: |
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Marc: |
LEADER 02668naa a2200277 a 4500
001 2131382
005 2021-04-20
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.mtcomm.2021.102333$2DOI
100 1 $aSILVÉRIO NETO, W.
245 $aNanodispersions of magnetic poly(vinyl pivalate) for biomedical applications$bSynthesis and in vitro evaluation of its cytotoxicity in cancer cells.$h[electronic resource]
260 $c2021
300 $cil. color.
520 $aThe development of polymeric nanomaterials, combining properties of polymers and superparamagnetic nanoparticles, has potential for biomedical applications, such as treatment of tumors through intravascular embolization and hyperthermia. Therefore, this work aims at development of a new magnetopolymeric fluid formed by magnetic nanoparticles of iron oxide (Fe3O4) coated with chemically modified oleic acid and which were uniformly dispersed in spherical nanoparticles of poly(vinyl pivalate) through in situ polymerization process via miniemulsion, synthesized using from 5.0 to 20.0 wt% of magnetic oxide in relation to vinyl pivalate content. Samples were characterized by infrared absorption vibration spectroscopy, thermogravimetric analysis, dynamic light scattering, differential scanning calorimetry, X-ray diffraction, transmission electron microscopy, Mössbauer spectroscopy, Raman spectroscopy, vibrating sample magnetometer and magnetic induction heating test. Cytotoxicity was evaluated in vitro in B16F10 melanoma cancer cells, murine mammary adenocarcinoma (4T1-luciferase), NIH-3T3 fibroblast cells and human keratinocytes (HaCat). The magnetopolymeric fluids exhibited maximum conversions of approximately 82 %, hydrodynamic diameter of 180 nm, spherical morphology, preserved superparamagnetic behavior and glass transition temperature ranging from 56.2 to 62.5 °C. Cell viability tests demonstrated that nanocomposites presented low cytotoxicity to tumor and non-tumor cells at concentrations studied. These results suggest potential of magnetopolymeric fluids as an embolic agent for selective and complete obstruction of blood vessels of different sizes and capacity for treatment by hyperthermia.
653 $aHyperthermia
653 $aMiniemulsion polymerization
653 $aPoly(vinyl pivalate)
653 $aSuperparamagnetic nanoparticles
653 $aVascular embolization
700 1 $aDUTRA, G. V. S.
700 1 $aBRITO NETA, M. de S.
700 1 $aCHAVES, S. B.
700 1 $aVALADARES, L. F.
700 1 $aSOUZA JÚNIOR, F. G. de
700 1 $aMACHADO, F.
773 $tMaterials Today Communications$gv. 27, 102333, June 2021.
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| 2. |  | FORNAROLLI, D. A.; GAZZIERO, D. L. P.; BONOTTO, A. T.; SANTOS, B. C. dos; DEBASTIANI, R.; BANDEIRA, S. A. E. Manejo de biotípos de digitaria insularis resistente ao herbicida glifosato. In: SIMPÓSIO INTERNACIONAL SOBRE GLYPHOSATE, 3., 2011, Botucatu. Uso sustentável: trabalhos científicos. Botucatu: FEPAF, 2011. p. 317-320.| Tipo: Artigo em Anais de Congresso |
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| 3. | | SANTOS, B. C. dos S.; ALFAYA JÚNIOR, H.; GIONGO, V.; SILVA, J. B. da; VOLTOLINI, T. V.; MORAES, S. A. de. Correlação do fósforo no sistema solo-planta-animal em pastagem natural na região da Campanha-RS. In: CONGRESSO BRASILEIRO DE NUTRIÇÃO ANIMAL, 1., 2008, Fortaleza. Bioecnologia aplicada na produção de rações: anais. Fortaleza: SEBRAE-CE, 2008. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
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| 4. | | FORNAROLLI, D. A.; GAZZIERO, D. L. P.; JORT, F. G.; SANTOS, B. C. dos; DEBSATIANI, R.; BONOTTO, A. T.; BANDEIRA, S. A. E.; SOBERANSKI, A. Herbicida saflufenacil no manejo de biotípos de Conyza sp. resistente ao herbicida glifosato. In: SIMPÓSIO INTERNACIONAL SOBRE GLYPHOSATE, 3., 2011, Botucatu. Uso sustentável: trabalhos científicos. Botucatu: FEPAF, 2011. p. 313-316.| Tipo: Artigo em Anais de Congresso |
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