Data/hora: 09/06/2024 01:15:43

Biblioteca(s): | Embrapa Agricultura Digital; Embrapa Gado de Corte.
Data corrente: | 17/07/2018
Data da última atualização: | 27/09/2018
Autoria: | ANDREOTTI, R.; GIACHETTO, P. F.; CUNHA, R. C.
Afiliação: | RENATO ANDREOTTI E SILVA, CNPGC; POLIANA FERNANDA GIACHETTO, CNPTIA; RODRIGO CASQUERO CUNHA, Bolsista PNPD/Capes.
Título: | Advances in tick vaccinology in Brazil: from gene expression to immunoprotection.
Ano de publicação: | 2018
Fonte/Imprenta: | Frontiers in Bioscience - Scholar, v. 10, n. 1, p. 127-142, Jan. 2018
Idioma: | Inglês
Conteúdo: | Rhipicephalus (Boophilus) microplus has substantial economic impact on the cattle breeding industry and, chemical control and tick resistance development are the major concern. There is a worldwide search for new options, and control using vaccines has been the main focus nowadays. Studies performed in Brazil found that Bm86-based immunization of bovines reduced the infestation of R. (B.) microplus of vaccinated bovines by 45% to 60%. Native Boophilus microplus tripsin inhibitors (BmTIs) with trypsin-, kallikrein-, and elastase-inhibiting activities have been used as immunogens in bovines reaching 72.8.% of efficacy. The reverse vaccinology approach has also been used for antigen search using transcriptome analysis to identify and characterize potential antigens. Study has generated more than 600 million sequences using RNA-seq of larvae, nymphs, salivary glands, intestines, and ovaries of the tick R. (B) microplus. Based on the set of transcripts obtained using this strategy, a total of 20,326 protein sequences have been identified. A pipeline analysis built in house identified the protein sequences that were most likely to be immunogenic based on the overall structural characteristic analysis.
Thesagro: | Vacina.
Thesaurus Nal: | Gene expression; Rhipicephalus microplus; Transcriptome; Vaccines.

Categoria do assunto:

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X Pesquisa, Tecnologia e Engenharia

Registro original: | Embrapa Gado de Corte (CNPGC)

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