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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
18/09/2007 |
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Data da última atualização: |
06/01/2015 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ANDRADE-NETO, V. F. de; POHLIT, A. M.; PINTO, A. C. S.; SILVA, E. C. C.; NOGUEIRA, K. L.; MELO, M. R. S.; HENRIQUE, M. C.; AMORIM, R. C. N.; SILVA, L. F. R.; COSTA, M. R. F.; NUNOMURA, R. C. S.; NUNOMURA, S. M.; ALECRIM, W. D.; ALECRIM, M. das G. C.; CHAVES, F. C. M.; VIEIRA, P. P. R. |
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Afiliação: |
Valter F. de Andrade-Neto, Inpa; Adrian M. Pohlit, Inpa; Ana Cristina S. Pinto, Inpa/Ufam; Ellen Cristina C. Silva, Inpa/Ufam; Karla L. Nogueira, Inpa/CEFET-AM; Márcia R.S. Melo, Inpa/FMTM; Marycleuma C. Henrique, Inpa/Ufam; Rodrigo C.N. Amorim, Inpa/Ufam; Luis Francisco R. Silva, FMTM; Mônica R.F. Costa, FMTM; Rita C.S. Nunomura, Inpa; Sergio M. Nunomura, Inpa; Wilson D. Alecrim, FMTM; Maria das Graças C. Alecrim, Inpa/UniNilton Lins; Francisco Célio Maia Chaves, CPAA; Pedro Paulo R. Vieira, UEA. |
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Título: |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. |
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Ano de publicação: |
2007 |
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Fonte/Imprenta: |
Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 359-365, jun. 2007. |
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Idioma: |
Inglês |
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Conteúdo: |
In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived. |
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Palavras-Chave: |
Isolação in vitro. |
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Thesagro: |
Planta. |
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Thesaurus Nal: |
Amazonia; malaria; Plasmodium falciparum. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/114925/1/5792.pdf
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Marc: |
LEADER 02028naa a2200361 a 4500
001 1681123
005 2015-01-06
008 2007 bl uuuu u00u1 u #d
100 1 $aANDRADE-NETO, V. F. de
245 $aIn vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants.
260 $c2007
520 $aIn the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived.
650 $aAmazonia
650 $amalaria
650 $aPlasmodium falciparum
650 $aPlanta
653 $aIsolação in vitro
700 1 $aPOHLIT, A. M.
700 1 $aPINTO, A. C. S.
700 1 $aSILVA, E. C. C.
700 1 $aNOGUEIRA, K. L.
700 1 $aMELO, M. R. S.
700 1 $aHENRIQUE, M. C.
700 1 $aAMORIM, R. C. N.
700 1 $aSILVA, L. F. R.
700 1 $aCOSTA, M. R. F.
700 1 $aNUNOMURA, R. C. S.
700 1 $aNUNOMURA, S. M.
700 1 $aALECRIM, W. D.
700 1 $aALECRIM, M. das G. C.
700 1 $aCHAVES, F. C. M.
700 1 $aVIEIRA, P. P. R.
773 $tMemórias do Instituto Oswaldo Cruz, Rio de Janeiro$gv. 102, n. 3, p. 359-365, jun. 2007.
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Registro original: |
Embrapa Amazônia Ocidental (CPAA) |
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