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Registro Completo |
Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Gado de Leite; Embrapa Instrumentação; Embrapa Pecuária Sudeste. |
Data corrente: |
25/01/2024 |
Data da última atualização: |
11/04/2024 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
ANHOLETO, L. A.; BRANCAGLION, G. A.; SANTOS, D. M. DOS; KAPRITCHKOFF, R. T. I.; CASTRO, K. N. de C.; CANUTO, K. M.; RODRIGUES, R. A. F.; CORREA, D. S.; CHAGAS, A. C. de S.; PASTRE, J. C. |
Afiliação: |
LUIS ADRIANO ANHOLETO; GUILHERME ANDRADE BRANCAGLION, UNIVERSIDADE DE CAMPINAS; DANILO MARTINS DOS SANTOS; RAFAELA TAMI IKEDA KAPRITCHKOFF, UNIVERSIDADE DE SÃO PAULO; KARINA NEOOB DE CARVALHO CASTRO, CNPGL; KIRLEY MARQUES CANUTO, CNPAT; RODNEY ALEXANDRE FERREIRA RODRIGUES, UNIVERSIDADE DE CAMPINAS; DANIEL SOUZA CORREA, CNPDIA; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; JULIO CEZAR PASTRE, UNIVERSIDADE DE CAMPINAS. |
Título: |
Acaricidal activity of synthetic spilanthol derivative against ticks of medical and veterinary importance. |
Ano de publicação: |
2024 |
Fonte/Imprenta: |
Veterinary Parasitology, v. 327, Apr. 2024, 110137. |
Páginas: |
9 p. |
DOI: |
10.1016/j.vetpar.2024.110137 |
Idioma: |
Inglês |
Conteúdo: |
The ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer and environmentally friendly. MenosThe ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer ... Mostrar Tudo |
Palavras-Chave: |
Acmella oleracea; Bovine parasite sadness; Brazilian Spotted Fever; Cattle tick; Control; Nanoformulation; Spilanthol. |
Thesagro: |
Bovino; Carrapato. |
Thesaurus Nal: |
Rickettsia rickettsii. |
Categoria do assunto: |
H Saúde e Patologia |
Marc: |
LEADER 02636naa a2200373 a 4500 001 2161314 005 2024-04-11 008 2024 bl uuuu u00u1 u #d 024 7 $a10.1016/j.vetpar.2024.110137$2DOI 100 1 $aANHOLETO, L. A. 245 $aAcaricidal activity of synthetic spilanthol derivative against ticks of medical and veterinary importance.$h[electronic resource] 260 $c2024 300 $a9 p. 520 $aThe ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer and environmentally friendly. 650 $aRickettsia rickettsii 650 $aBovino 650 $aCarrapato 653 $aAcmella oleracea 653 $aBovine parasite sadness 653 $aBrazilian Spotted Fever 653 $aCattle tick 653 $aControl 653 $aNanoformulation 653 $aSpilanthol 700 1 $aBRANCAGLION, G. A. 700 1 $aSANTOS, D. M. DOS 700 1 $aKAPRITCHKOFF, R. T. I. 700 1 $aCASTRO, K. N. de C. 700 1 $aCANUTO, K. M. 700 1 $aRODRIGUES, R. A. F. 700 1 $aCORREA, D. S. 700 1 $aCHAGAS, A. C. de S. 700 1 $aPASTRE, J. C. 773 $tVeterinary Parasitology$gv. 327, Apr. 2024, 110137.
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Embrapa Agroindústria Tropical (CNPAT) |
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88. | | ANDRE, R. S.; MERCANTE, L. A.; PEREIRA, J.; MATTOSO, L. H. C.; CORREA, D. S. Gas sensing performance of electrospun ceramic nanofibers decorated with graphene oxide. In: BRAZIL MRS MEETING - SBPMAT, 17, 2018, Natal, RN. Proceedings... Natal, RN: SBPMat, 2018.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Instrumentação. |
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89. | | CORREA, D. S.; CARDOSO, M. R.; TRIBUZI, V.; MISOGUTI, L.; MENDONÇA, C. R. Femtosecond laser in polymeric materials: microfabrication of doped structures and micromachining. IEEE Journal of Selected Topics in Quantum Electronics, Nova York, v. 18, n. 1, p. 176-186, 2012.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
Biblioteca(s): Embrapa Instrumentação. |
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90. | | ALMEIDA FILHO, J.; MANZOLI, A.; ALMEIDA, G. F. B. de; MENDONÇA, C. R.; CORREA, D. S. Fabricação de microeletrodos interdigitados utilizando laser pulsado visando aplicações em sensores. In: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 6., 2014, São Carlos, SP Anais... São Carlos: Embrapa Instrumentação: Embrapa Pecuária Sudeste, 2014. p. 41. Editores técnicos: João de Mendonça Naime, Caue Ribeiro, Maria Alice Martins, Elaine Cristina Paris, Paulino Ribeiro Villas Boas, Ladislau Marcelino Rabello. (Embrapa Instrumentação. Documentos, 57).Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Instrumentação. |
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91. | | MERCANTE, L. A.; NOGUEIRA, M. S.; CORREA, D. S.; MATTOSO, L. H. C. Filmes nanoestruturados baseados em nanopartículas de ouro/ftalocianinas para aplicação em sensores do tipo língua eletrônica. In: WORKSHOP DA REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 8, 2014, Juiz de fora. Anais... São Carlos: Embrapa Instrumentação; Campo Grande: Embrapa Gado de Corte; Juiz de Fora: Embrapa Gado de Leite, 2014. p. 35-39. Editores: Maria Alice Martins, Humberto de Mello Brandão, Marlene de Barros Coelho, Daniel Souza Corrêa, Caue Ribeiro, Luiz Henrique Capparelli Mattoso.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Instrumentação. |
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94. | | OHASHI, T. L.; SPRICIGO, P. C.; FERREIRA, M. D.; CORREA, D. S. Ensaios preliminares no controle do amadurecimento de frutos e hortaliças através do desenvolvimento de absorvedores de etileno. In: WORKSHOP DA REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 6., 2012, Fortaleza. Anais... São Carlos: Embrapa Instrumentação; Fortaleza: Embrapa Agroindústria Tropical, 2012. p. 440-442. Editores: Maria Alice Martins, MOrsyleide de Freitas Rosa, Men de Sá Moreira de Souza Filho, Nicodemos Moreira dos Santos Junior, Odílio Benedito Garrido de Assis, Caue Ribeiro, Luiz Henrique Capparelli Mattoso.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Instrumentação. |
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95. | | ALMEIDA, G. F.; CARDOSO, M. R.; MENDONÇA, C. R.; CORREA, D. S. Emprego de laser na modificação de substratos recobertos com ouro para fabricação de eletrodos interdigitados. In: WORKSHOP DA REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 6., 2012, Fortaleza. Anais... São Carlos: Embrapa Instrumentação; Fortaleza: Embrapa Agroindústria Tropical, 2012. p. 21-23. Editores: Maria Alice Martins, MOrsyleide de Freitas Rosa, Men de Sá Moreira de Souza Filho, Nicodemos Moreira dos Santos Junior, Odílio Benedito Garrido de Assis, Caue Ribeiro, Luiz Henrique Capparelli Mattoso.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Instrumentação. |
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