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Registro Completo |
Biblioteca(s): |
Embrapa Agricultura Digital. |
Data corrente: |
31/01/2018 |
Data da última atualização: |
21/01/2020 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
CHUD, T. C. S.; BICKHART, D. M.; ZERLOTINI NETO, A.; COLE, J. B.; SILVA, M. V. G. B.; MUNARI, D. P. |
Afiliação: |
TATIANE C. S. CHUD, FCAV/Unesp; DEREK M. BICKHART, FCAV/Unesp; ADHEMAR ZERLOTINI NETO, CNPTIA; JOHN B. COLE, Usda; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; DANÍSIO P. MUNARI, FCAV/Unesp. |
Título: |
Copy number variation in dairy cattle using next-generation sequencing. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
In: PLANT AND ANIMAL GENOME CONFERENCE, 26., 2018, San Diego. Abstracts... [S.l.: s.n.], 2018. |
Páginas: |
1 p. |
Idioma: |
Inglês |
Notas: |
PAG 2018. P0490. Na publicação: Adhemar Zerlotini, Marcos Vinicius B. da Silva. |
Conteúdo: |
Gene copy number variants (CNV) have been shown to be associated with several production traits in dairy cattle; however, the detection and validation of CNVs in crossbred cattle is currently lacking. In order to provide a basis for future association studies, we sought to identify CNV regions (CNVRs) within the Girolando composite breed resulting from a mating of the Holstein (taurine) and Gir (indicine) breeds. A read depth method was performed using CNVnator software on NGS data from two Girolando, two Gir and ten Holstein bulls. The individual CNVs were merged into CNVRs based on genomic regions overlapping by at least 1 bp. In total, we identified a composite of 1,286 CNVRs (520 deletions, 255 duplications, 511 mixed) on the genomes of all samples. We observed 34 CNVRs (nine deletions, 25 mixed) in common (overlapping > 50%) only between Girolando and Holstein and 181 CNVRs (20 deletions, 21 duplications,140 mixed) only in Girolando and Gir, suggesting parent-of-origin inheritance from Holstein and Gir cattle, respectively. One of these Holstein-specific CNVRs intersected with the interleukin 6 family cytokine (LIF) gene which is linked to fat production and fertility traits in Holstein. Genes related to disease resistance (e.g. the CD4 gene) also coincided with CNVRs present only in Gir and Girolando cattle suggesting an indicine origin for the CNV. These results showed evidence of specific CNVRs shared by Girolando and purebred breeds which may be targeted for future selective breeding. MenosGene copy number variants (CNV) have been shown to be associated with several production traits in dairy cattle; however, the detection and validation of CNVs in crossbred cattle is currently lacking. In order to provide a basis for future association studies, we sought to identify CNV regions (CNVRs) within the Girolando composite breed resulting from a mating of the Holstein (taurine) and Gir (indicine) breeds. A read depth method was performed using CNVnator software on NGS data from two Girolando, two Gir and ten Holstein bulls. The individual CNVs were merged into CNVRs based on genomic regions overlapping by at least 1 bp. In total, we identified a composite of 1,286 CNVRs (520 deletions, 255 duplications, 511 mixed) on the genomes of all samples. We observed 34 CNVRs (nine deletions, 25 mixed) in common (overlapping > 50%) only between Girolando and Holstein and 181 CNVRs (20 deletions, 21 duplications,140 mixed) only in Girolando and Gir, suggesting parent-of-origin inheritance from Holstein and Gir cattle, respectively. One of these Holstein-specific CNVRs intersected with the interleukin 6 family cytokine (LIF) gene which is linked to fat production and fertility traits in Holstein. Genes related to disease resistance (e.g. the CD4 gene) also coincided with CNVRs present only in Gir and Girolando cattle suggesting an indicine origin for the CNV. These results showed evidence of specific CNVRs shared by Girolando and purebred breeds which may be targeted for future ... Mostrar Tudo |
Palavras-Chave: |
Copy number variants. |
Thesagro: |
Gado. |
Thesaurus Nal: |
Cattle; Composite breeds. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/171991/1/PL-CopyNumber-PAGXXVI.pdf
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Marc: |
LEADER 02304nam a2200241 a 4500 001 2086860 005 2020-01-21 008 2018 bl uuuu u00u1 u #d 100 1 $aCHUD, T. C. S. 245 $aCopy number variation in dairy cattle using next-generation sequencing.$h[electronic resource] 260 $aIn: PLANT AND ANIMAL GENOME CONFERENCE, 26., 2018, San Diego. Abstracts... [S.l.: s.n.]$c2018 300 $a1 p. 500 $aPAG 2018. P0490. Na publicação: Adhemar Zerlotini, Marcos Vinicius B. da Silva. 520 $aGene copy number variants (CNV) have been shown to be associated with several production traits in dairy cattle; however, the detection and validation of CNVs in crossbred cattle is currently lacking. In order to provide a basis for future association studies, we sought to identify CNV regions (CNVRs) within the Girolando composite breed resulting from a mating of the Holstein (taurine) and Gir (indicine) breeds. A read depth method was performed using CNVnator software on NGS data from two Girolando, two Gir and ten Holstein bulls. The individual CNVs were merged into CNVRs based on genomic regions overlapping by at least 1 bp. In total, we identified a composite of 1,286 CNVRs (520 deletions, 255 duplications, 511 mixed) on the genomes of all samples. We observed 34 CNVRs (nine deletions, 25 mixed) in common (overlapping > 50%) only between Girolando and Holstein and 181 CNVRs (20 deletions, 21 duplications,140 mixed) only in Girolando and Gir, suggesting parent-of-origin inheritance from Holstein and Gir cattle, respectively. One of these Holstein-specific CNVRs intersected with the interleukin 6 family cytokine (LIF) gene which is linked to fat production and fertility traits in Holstein. Genes related to disease resistance (e.g. the CD4 gene) also coincided with CNVRs present only in Gir and Girolando cattle suggesting an indicine origin for the CNV. These results showed evidence of specific CNVRs shared by Girolando and purebred breeds which may be targeted for future selective breeding. 650 $aCattle 650 $aComposite breeds 650 $aGado 653 $aCopy number variants 700 1 $aBICKHART, D. M. 700 1 $aZERLOTINI NETO, A. 700 1 $aCOLE, J. B. 700 1 $aSILVA, M. V. G. B. 700 1 $aMUNARI, D. P.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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Registro Completo
Biblioteca(s): |
Embrapa Trigo. |
Data corrente: |
24/04/2008 |
Data da última atualização: |
12/08/2015 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
Internacional - A |
Autoria: |
DEL PONTE, E. M.; FERNANDES, J. M. C.; BERGSTROM, G. C. |
Afiliação: |
José Maurício Cunha Fernandes, Embrapa Trigo. |
Título: |
Influence of growth stage on fusarium head blight and deoxynivalenol production in wheat. |
Ano de publicação: |
2007 |
Fonte/Imprenta: |
Journal of Phytopathology, Berlin, v. 155, n. 10, p. 577-581, 2007. |
Idioma: |
Inglês |
Thesagro: |
Giberela; Trigo. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/127850/1/SP-15391.pdf
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Marc: |
LEADER 00482naa a2200157 a 4500 001 1841113 005 2015-08-12 008 2007 bl uuuu u00u1 u #d 100 1 $aDEL PONTE, E. M. 245 $aInfluence of growth stage on fusarium head blight and deoxynivalenol production in wheat. 260 $c2007 650 $aGiberela 650 $aTrigo 700 1 $aFERNANDES, J. M. C. 700 1 $aBERGSTROM, G. C. 773 $tJournal of Phytopathology, Berlin$gv. 155, n. 10, p. 577-581, 2007.
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