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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Semiárido. |
Data corrente: |
03/01/2020 |
Data da última atualização: |
03/07/2020 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
GUEDES, J. A. C.; ALVES FILHO, E. DE G.; SILVA, M. F. S.; RODRIGUES, T. H. S.; RAMIRES, C. M. C.; LIMA, M. A. C. de; SILVA, G. S. DA; PESSOA, C. DO Ó; CANUTO, K. M.; BRITO, E. S. de; ALVES, R. E.; NASCIMENTO, R. F. DO; ZOCOLO, G. J. |
Afiliação: |
JHONYSON ARRUDA CARVALHO GUEDES, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará; ELENILSON DE GODOY ALVES FILHO, Embrapa Agroindústria Tropical; MARIA FRANCILENE SOUZA SILVA, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará; TIGRESSA HELENA SOARES RODRIGUES, Universidade Estadual do Vale do Acaraú, Sobral; CHRISTIANE MENDES CASSIMIRO RAMIRES, Empresa Estadual de Pesquisa Agropecuária da Paraíba (EMEPA); MARIA AUXILIADORA COELHO DE LIMA, CPATSA; GISELE SILVESTRE DA SILVA, Embrapa Agroindústria Tropical; CLAUDIA DO Ó PESSOA, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará; KIRLEY MARQUES CANUTO, CNPAT; EDY SOUSA DE BRITO, CNPAT; RICARDO ELESBAO ALVES, CNAT; RONALDO FERREIRA DO NASCIMENTO, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará; GUILHERME JULIAO ZOCOLO, CNPAT. |
Título: |
GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. |
Ano de publicação: |
2020 |
Fonte/Imprenta: |
Journal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020. |
DOI: |
https://doi.org/10.21577/0103-5053.20190185 |
Idioma: |
Inglês |
Conteúdo: |
Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds |
Palavras-Chave: |
Agroindustria; Co-produto; Metabolômica; Residuo agroindustrial. |
Thesagro: |
Cromatografia; Spondias Mombin; Umbu. |
Thesaurus NAL: |
Chromatography; Metabolomics; Spondias; Yellow mombins. |
Categoria do assunto: |
-- F Plantas e Produtos de Origem Vegetal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/208109/1/ART19066.pdf
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/210746/1/Based-Metabolomic-Profiles-Combined-with-Chemometric-Tools.pdf
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Marc: |
LEADER 02354naa a2200409 a 4500 001 2118083 005 2020-07-03 008 2020 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.21577/0103-5053.20190185$2DOI 100 1 $aGUEDES, J. A. C. 245 $aGC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.$h[electronic resource] 260 $c2020 520 $aAgroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds 650 $aChromatography 650 $aMetabolomics 650 $aSpondias 650 $aYellow mombins 650 $aCromatografia 650 $aSpondias Mombin 650 $aUmbu 653 $aAgroindustria 653 $aCo-produto 653 $aMetabolômica 653 $aResiduo agroindustrial 700 1 $aALVES FILHO, E. DE G. 700 1 $aSILVA, M. F. S. 700 1 $aRODRIGUES, T. H. S. 700 1 $aRAMIRES, C. M. C. 700 1 $aLIMA, M. A. C. de 700 1 $aSILVA, G. S. DA 700 1 $aPESSOA, C. DO Ó 700 1 $aCANUTO, K. M. 700 1 $aBRITO, E. S. de 700 1 $aALVES, R. E. 700 1 $aNASCIMENTO, R. F. DO 700 1 $aZOCOLO, G. J. 773 $tJournal of the Brazilian Chemical Society, Campinas$gv. 31, n. 2, p. 331-340, 2020.
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Embrapa Agroindústria Tropical (CNPAT) |
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