| |
|
|
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Meio-Norte. |
|
Data corrente: |
23/06/1997 |
|
Data da última atualização: |
28/11/2014 |
|
Autoria: |
CHANG, M. N. |
|
Título: |
Optimal designs for group sequential clinical trials. |
|
Ano de publicação: |
1996 |
|
Fonte/Imprenta: |
Communications in Statistics - Theory and Methods, v. 25, n. 2, p. 361-379, 1996. |
|
Idioma: |
Inglês |
|
Conteúdo: |
Group sequential tests have seen wide use in clinical trials. In this article a group sequential design is referred to an optimal one if the expected sample size under specified alternative is minimized for a given choice of significance level and power among tests with a given sequence of groups of specific sizes. The optimal designs provide a standard for assessing the efficiency of many designs in the literature. This article concerns optimal two-sided tests with acceptance regions of the null hypothesis at early stages. We show that the backward induction method can be applied to compute optimal designs for group sequential tests. Subsequently we develop a numerical iterative procedure to compute the stopping boundaries of two-sided optimal sequential tests. Some numerical results are presented. The method can be generalized to one-sided tests and to-sided tests without acceptance regions of the null hypothesis at early stages. |
|
Palavras-Chave: |
Admissible design; Admissible design surface; Average sample size; Backward induction; Bayes solution; Delineamento experimental. |
|
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
|
Marc: |
LEADER 01522naa a2200193 a 4500
001 1050619
005 2014-11-28
008 1996 bl --- 0-- u #d
100 1 $aCHANG, M. N.
245 $aOptimal designs for group sequential clinical trials.
260 $c1996
520 $aGroup sequential tests have seen wide use in clinical trials. In this article a group sequential design is referred to an optimal one if the expected sample size under specified alternative is minimized for a given choice of significance level and power among tests with a given sequence of groups of specific sizes. The optimal designs provide a standard for assessing the efficiency of many designs in the literature. This article concerns optimal two-sided tests with acceptance regions of the null hypothesis at early stages. We show that the backward induction method can be applied to compute optimal designs for group sequential tests. Subsequently we develop a numerical iterative procedure to compute the stopping boundaries of two-sided optimal sequential tests. Some numerical results are presented. The method can be generalized to one-sided tests and to-sided tests without acceptance regions of the null hypothesis at early stages.
653 $aAdmissible design
653 $aAdmissible design surface
653 $aAverage sample size
653 $aBackward induction
653 $aBayes solution
653 $aDelineamento experimental
773 $tCommunications in Statistics - Theory and Methods$gv. 25, n. 2, p. 361-379, 1996.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Meio-Norte (CPAMN) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 10 | |
| 2. |  | CHANG, M.; BURNQUIST, H. L.; COSTA, C. C. da. Exportações brasileiras para a China: padrões de especialização e competitividade. In: CONGRESSO DA APDEA, 7.; CONGRESSO DA SPER, 5.; ENCONTRO LUSÓFONO EM ECONOMIA, SOCIOLOGIA, AMBIENTE E DESENVOLVIMENTO RURAL, 1., 2013, Évora. Alimentar mentalidades, vencer a crise global: Atlas do ESADR 2013: proceedings. Évora: Universidade de Évora, 2013. p. 2687-2706. P02. Coordenado por Maria Leonor da Silva Carvalho, Pedro Damião de Sousa Henriques, Vanda Narciso.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
|   |
| 7. | | GOUVEIA, E. M. F.; SILVA, I. S.; NAKAZATO, G.; ONSELEM, V. J. V.; CORRÊA, R. A. C.; ARAUJO, F. R.; CHANG, M. R. Action of phosphorylated mannanoligosaccharides on immune and hematological responses and fecal consistency of dogs experimentally infected with enteropathogenic Escherichia coli strains. Brazilian Journal of Microbiology, v. 44, n. 2, 499-504 (2013)| Biblioteca(s): Embrapa Gado de Corte. |
|  |
| 8. | | XAVIER, P. C. N.; CHANG, M. R.; PAULA, C. R.; MATSUMOTO, F. E.; ASENSI, M. D.; MATOS, M. de F. C.; ANDREOTTI, R. Molecular characterization of Candida spp. isolates from patients with bloodstream infections. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba. MG, v. 46, n.6 nov./dez. 2013. p.786-787.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 5 |
| Biblioteca(s): Embrapa Gado de Corte. |
|  |
| 9. | | OLIVEIRA, E. B. de; SOUSA, L. P. de; FROUFE, L. C. M.; AGUIAR, A. V. de; LEMBERGER, E.; SANTOS, L. M. F. dos; FREITAS, J. C. de; GOBOR, D.; SCHAITZA, E. G.; MAXIMIANO, G. A.; CHANG, M. Avaliação de uma floresta de espécies nativas formada em sub-bosque de plantação de eucalipto, no noroeste do Estado do Paraná. In: SEMINÁRIO NACIONAL SOBRE DINÂMICAS DE FLORESTAS, 1., 2008, Curitiba. Anais. Colombo: Embrapa Florestas, 2008. 1 CD-ROM. Resumo 49.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Florestas. |
| |
| 10. | | DIB, H. X.; OLIVEIRA, D. G. L. de; OLIVEIRA, C. F. R. de; TAVEIRA, G. B.; MELLO, E. de O.; VERBISCK, N. V.; CHANG, M. R.; CORRÊA JUNIOR, D.; GOMES, V. M.; MACEDO, M. L. R. Biochemical characterization of a Kunitz inhibitor from Inga edulis seeds with antifungal activity against Candida spp. Archives of Microbiology, v. 201, n. 2, p. 223?233, March 2019| Tipo: Artigo em Periódico Indexado |
| Biblioteca(s): Embrapa Gado de Corte. |
| |
| Registros recuperados : 10 | |
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
