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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
04/10/2019 |
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Data da última atualização: |
04/10/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MOREIRA, G. C. M.; SALVIAN, M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; LEDUR, M. C.; GARRICK, D.; MOURÃO, G. B.; COUTINHO, L. L. |
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Afiliação: |
GABRIEL COSTA MONTEIRO MOREIRA, ESALQ; MAYARA SALVIAN, ESALQ; CLARISSA BOSCHIERO, ESALQ; ALINE SILVA MELLO CESAR, ESALQ; JAMES M. REECY, Iowa State University/Department of Animal Science; THAIS FERNANDA GODOY, ESALQ; MONICA CORREA LEDUR, CNPSA; DORIAN J. GARRICK, Massey University/ School of Agriculture; GERSON BARRETO MOURÃO, ESALQ; LUIZ LEHMMAN COUTINHO, ESALQ. |
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Título: |
Genome-wide association scan for QTL and their positional candidate genes associated with internal organ traits in chickens. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
BMC Genomics, v. 20, n. 669, 2019. |
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DOI: |
10.1186/s12864-019-6040-3 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract Background: Poultry breeding programs have been focused on improvement of growth and carcass traits, however, this has resulted in correlated changes in internal organ weights and increased incidence of metabolic disorders. These disorders can affect feed efficiency or even cause death. We used a high density SNP array (600 K, Affymetrix) to estimate genomic heritability, perform genome-wide association analysis, and identify genomic regions and positional candidate genes (PCGs) associated with internal organ traits in an F2 chicken population. We integrated knowledge of haplotype blocks, selection signature regions and sequencing data to refine the list of PCGs. Results: Estimated genomic heritability for internal organ traits in chickens ranged from low (LUNGWT, 0.06) to high (GIZZWT, 0.45). A total of 20 unique 1 Mb windows identified on GGA1, 2, 4, 7, 12, 15, 18, 19, 21, 27 and 28 were significantly associated with intestine length, and weights or percentages of liver, gizzard or lungs. Within these windows, 14 PCGs were identified based on their biological functions: TNFSF11, GTF2F2, SPERT, KCTD4, HTR2A, RB1, PCDH7, LCORL, LDB2, NR4A2, GPD2, PTPN11, ITGB4 and SLC6A4. From those genes, two were located within haplotype blocks and three overlapped with selection signature regions. A total of 13,748 annotated sequence SNPs were in the 14 PCGs, including 156 SNPs in coding regions (124 synonymous, 26 non-synonymous, and 6 splice variants). Seven deleterious SNPs were identified in TNFSF11, NR4A2 or ITGB4 genes. Conclusions: The results from this study provide novel insights to understand the genetic architecture of internal organ traits in chickens. The QTL detection performed using a high density SNP array covered the whole genome allowing the discovery of novel QTL associated with organ traits. We identified PCGs within the QTL involved in biological processes that may regulate internal organ growth and development. Potential functional genetic variations were identified generating crucial information that, after validation, might be used in poultry breeding programs to reduce the occurrence of metabolic disorders. MenosAbstract Background: Poultry breeding programs have been focused on improvement of growth and carcass traits, however, this has resulted in correlated changes in internal organ weights and increased incidence of metabolic disorders. These disorders can affect feed efficiency or even cause death. We used a high density SNP array (600 K, Affymetrix) to estimate genomic heritability, perform genome-wide association analysis, and identify genomic regions and positional candidate genes (PCGs) associated with internal organ traits in an F2 chicken population. We integrated knowledge of haplotype blocks, selection signature regions and sequencing data to refine the list of PCGs. Results: Estimated genomic heritability for internal organ traits in chickens ranged from low (LUNGWT, 0.06) to high (GIZZWT, 0.45). A total of 20 unique 1 Mb windows identified on GGA1, 2, 4, 7, 12, 15, 18, 19, 21, 27 and 28 were significantly associated with intestine length, and weights or percentages of liver, gizzard or lungs. Within these windows, 14 PCGs were identified based on their biological functions: TNFSF11, GTF2F2, SPERT, KCTD4, HTR2A, RB1, PCDH7, LCORL, LDB2, NR4A2, GPD2, PTPN11, ITGB4 and SLC6A4. From those genes, two were located within haplotype blocks and three overlapped with selection signature regions. A total of 13,748 annotated sequence SNPs were in the 14 PCGs, including 156 SNPs in coding regions (124 synonymous, 26 non-synonymous, and 6 splice variants). Seven deleterious SNPs we... Mostrar Tudo |
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Palavras-Chave: |
Deleterious mutations; Genomic heritability; GWAS; Metabolic disorders. |
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Thesagro: |
Avicultura; Genética Animal; Genoma; Melhoramento Genético Animal. |
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Thesaurus Nal: |
Genomics; Gizzard; Heart; Intestines; Liver; Lungs; Metabolic diseases. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03326naa a2200421 a 4500
001 2112783
005 2019-10-04
008 2019 bl uuuu u00u1 u #d
024 7 $a10.1186/s12864-019-6040-3$2DOI
100 1 $aMOREIRA, G. C. M.
245 $aGenome-wide association scan for QTL and their positional candidate genes associated with internal organ traits in chickens.$h[electronic resource]
260 $c2019
520 $aAbstract Background: Poultry breeding programs have been focused on improvement of growth and carcass traits, however, this has resulted in correlated changes in internal organ weights and increased incidence of metabolic disorders. These disorders can affect feed efficiency or even cause death. We used a high density SNP array (600 K, Affymetrix) to estimate genomic heritability, perform genome-wide association analysis, and identify genomic regions and positional candidate genes (PCGs) associated with internal organ traits in an F2 chicken population. We integrated knowledge of haplotype blocks, selection signature regions and sequencing data to refine the list of PCGs. Results: Estimated genomic heritability for internal organ traits in chickens ranged from low (LUNGWT, 0.06) to high (GIZZWT, 0.45). A total of 20 unique 1 Mb windows identified on GGA1, 2, 4, 7, 12, 15, 18, 19, 21, 27 and 28 were significantly associated with intestine length, and weights or percentages of liver, gizzard or lungs. Within these windows, 14 PCGs were identified based on their biological functions: TNFSF11, GTF2F2, SPERT, KCTD4, HTR2A, RB1, PCDH7, LCORL, LDB2, NR4A2, GPD2, PTPN11, ITGB4 and SLC6A4. From those genes, two were located within haplotype blocks and three overlapped with selection signature regions. A total of 13,748 annotated sequence SNPs were in the 14 PCGs, including 156 SNPs in coding regions (124 synonymous, 26 non-synonymous, and 6 splice variants). Seven deleterious SNPs were identified in TNFSF11, NR4A2 or ITGB4 genes. Conclusions: The results from this study provide novel insights to understand the genetic architecture of internal organ traits in chickens. The QTL detection performed using a high density SNP array covered the whole genome allowing the discovery of novel QTL associated with organ traits. We identified PCGs within the QTL involved in biological processes that may regulate internal organ growth and development. Potential functional genetic variations were identified generating crucial information that, after validation, might be used in poultry breeding programs to reduce the occurrence of metabolic disorders.
650 $aGenomics
650 $aGizzard
650 $aHeart
650 $aIntestines
650 $aLiver
650 $aLungs
650 $aMetabolic diseases
650 $aAvicultura
650 $aGenética Animal
650 $aGenoma
650 $aMelhoramento Genético Animal
653 $aDeleterious mutations
653 $aGenomic heritability
653 $aGWAS
653 $aMetabolic disorders
700 1 $aSALVIAN, M.
700 1 $aBOSCHIERO, C.
700 1 $aCESAR, A. S. M.
700 1 $aREECY, J. M.
700 1 $aGODOY, T. F.
700 1 $aLEDUR, M. C.
700 1 $aGARRICK, D.
700 1 $aMOURÃO, G. B.
700 1 $aCOUTINHO, L. L.
773 $tBMC Genomics$gv. 20, n. 669, 2019.
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Embrapa Suínos e Aves (CNPSA) |
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| 42. |  | ZUMÁRRAGA, M. J.; CATALDI, A.; ARAUJO, F. R.; DIB, C. C.; ROXO, E. Caracterização genética de Mycobacterium bovis em animais de cinco estados brasileiros. O Biológico, São Paulo, SP, v. 74, n. 2, p 95 , jul./dez. 2012. Edição dos resumos da 25ª Reunião Anual do Instituto Biológico, São Paulo, 2012 e 10º Congresso de Iniciação Científica em Ciências Agrárias Biológicas e Ambientais - CICAM, agosto, 2012. Resumo 09.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Corte. |
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| 44. | | CARVALHO, J. A.; COELHO, M. de B.; ARAUJO, F. R.; FERREIRA, V. S. Desenvolvimento de imunossensor nanoestruturado para diagnóstico de tuberculose bovina. In: JORNADA CIENTÍFICA EMBRAPA GADO DE CORTE, 7., 2011, CAMPO GRANDE, MS. [Anais da]... Campo Grande, MS: Embrapa Gado de Corte, 2011.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Corte. |
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| 48. | | DALL'ACQUA, P. E.; SOBRAL, T. F.; KESSLER, R. H.; ARAUJO, F. R.; SOARES, C. O. Imunoproteção de bovinos contra Anaplasma marginale E Anaplasma centrale, obtidos por cultivo in vitro em células embrionárias de Boophilus microplus. In: JORNADA CIENTÍFICA DA EMBRAPA GADO DE CORTE, 1., 2005, Campo Grande, MS: Embrapa Gado de Corte, 2005. 1 p.| Biblioteca(s): Embrapa Gado de Corte. |
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| 49. | | SOBRAL, T. F.; DALL'ACQUA, P. E.; KESSLER, R. H.; ARAUJO, F. R.; SOARES, C. O. Imunoproteção de bovinos contra anaplasmose utilizando Anaplasma marginale e Anaplasma centrale obtidos de cultivos in vitro de células embrionárias de Boophilus microplus. In: JORNADA CIENTÍFICA DA EMBRAPA GADO DE CORTE, 1., 2005, Campo Grande, MS: Embrapa Gado de Corte, 2005. 1 p.| Biblioteca(s): Embrapa Gado de Corte. |
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| 50. | | SOARES, R.; RAMOS, C. A.; PEDROSO, T.; BABO-TERRA, V.; CLEVELAND, H.; ARAUJO, F. R. Molecular survey of Anaplasma platys and Ehrlichia canis in dogs from Campo Grande, Mato Grosso do Sul, Brazil. Anais da Academia Brasileira de Ciências, v. 89, n. 1, p. 301-306, 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Corte. |
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| 54. | | ARAUJO, F. R.; MADRUGA, C. R.; LEAL, C. R. B.; MASSUDA, T.; SCHENK, M. A. M. Desenvolvimento de uma prova de imunoadsorcao enzimatica (ELISA) para deteccao de anticorpos contra Trypanosoma vivax. Resultados preliminares. In : SEMINARIO BRASILEIRO DE PARASITOLOGIA VETERINARIA, 10.; SEMINARIO DE PARASITOLOGIA VETERINARIA DO MERCOSUL, 1., 1997, Itajai. Anais... Revista Brasileira de Parasitologia Veterinaria, Sao Paulo, v.6, n.2, p. 350, ago. 1997. Suplemento 1. Resumo P53. CNPGC.| Biblioteca(s): Embrapa Gado de Corte. |
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| 57. | | CEZAR, B. P; NISHIBE, C.; ALMEIDA, N. F.; ARAUJO, F. R.; MONTERA, L. Mapping short reads may be harder in anomalous . In: INTERNATIONAL SOCIETY FOR COMPUTATIONAL BIOLOGY LATIN AMERICA X-MEETING ON BIOINFORMATICS, 3., THE BRAZILIAN SYMPOSIUM ON BIOINFORMATICS; SOIBIO, 2014, Belo Horizonte. Program... [S.l.]: International Society for Computational Biology, 2014. ISCB-Latin America 2014.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Corte. |
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| 58. | | ARAUJO, F. R.; LEAL, C. R. B.; MADRUGA, C. R.; MIGUITA, M.; CARVALHO, E. L. L. Levantamento sorologico para Anaplasma marginale em duas microrregioes do Estado da Bahia. In: SEMINARIO BRASILEIRO DE PRASITOLOGIA VETERINARIA, 9., 1995, Campo Grande. Anais. Revista Brasileira de Parasitologia Veterinaria, Sao Paulo, v.4, n.2, p.188, ago., 1995. Suplemento, 1. CNPGC. Resumo| Biblioteca(s): Embrapa Gado de Corte. |
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| 59. | | MENK, J. C. F.; ALMEIDA, M. A. O.; MADRUGA, C. R.; ARAUJO, F. R. Levantamento sorologico da Babesia bovis e Babesia bigemina, no semi-arido baiano, pela tecnica de imunoadsorcao enzimatica (ELISA). In: SEMINARIO BRASILEIRO DE PARASITOLOGIA VETERINARIA, 11., SEMINARIO DE PARASITOLOGIA VETERINARIA DOS PAISES DO MERCOSUL, 2; SIMPOSIO DE CONTROLE INTEGRADO DE PARASITOS DE BOVINOS, 1., 1999, Salvador. Anais... Ilheus: Colegio Brasileiro de Parasitolgia Veterinaria, [1999?]. p.205. CNPGC. Resumo TL-PB-461.| Biblioteca(s): Embrapa Gado de Corte. |
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| Registros recuperados : 351 | |
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