|
|
| Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo |
Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Pecuária Sudeste; Embrapa Pecuária Sul. |
Data corrente: |
25/03/2024 |
Data da última atualização: |
25/03/2024 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
CARVALHO, W. A.; GASPAR, E. B.; DOMINGUES, R.; REGITANO, L. C. de A.; CARDOSO, F. F. |
Afiliação: |
WANESSA ARAUJO CARVALHO, CNPGL; EMANUELLE BALDO GASPAR, CNPGL; ROBERT DOMINGUES, CNPGL; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; FERNANDO FLORES CARDOSO, CPPSUL. |
Título: |
Genetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle: a systems biology perspective. |
Ano de publicação: |
2024 |
Fonte/Imprenta: |
Mammalian Genome, 2024. |
DOI: |
https://doi.org/10.1007/s00335-024-10030-x |
Idioma: |
Inglês |
Notas: |
First online. |
Conteúdo: |
Approximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle. MenosApproximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates ... Mostrar Tudo |
Thesagro: |
Bovino; Carrapato; Doença Animal; Parasitismo; Resistência. |
Thesaurus Nal: |
Amber disease; Parasitism; Ticks. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
Marc: |
LEADER 02431naa a2200289 a 4500 001 2163111 005 2024-03-25 008 2024 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1007/s00335-024-10030-x$2DOI 100 1 $aCARVALHO, W. A. 245 $aGenetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle$ba systems biology perspective.$h[electronic resource] 260 $c2024 500 $aFirst online. 520 $aApproximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle. 650 $aAmber disease 650 $aParasitism 650 $aTicks 650 $aBovino 650 $aCarrapato 650 $aDoença Animal 650 $aParasitismo 650 $aResistência 700 1 $aGASPAR, E. B. 700 1 $aDOMINGUES, R. 700 1 $aREGITANO, L. C. de A. 700 1 $aCARDOSO, F. F. 773 $tMammalian Genome, 2024.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Gado de Leite (CNPGL) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
Registro Completo
Biblioteca(s): |
Embrapa Uva e Vinho. |
Data corrente: |
15/09/2014 |
Data da última atualização: |
18/01/2019 |
Tipo da produção científica: |
Folder/Folheto/Cartilha |
Autoria: |
KOVALESKI, A.; BOTTON, M.; SANTOS, R. S. S. dos; ALVES, S. A. M. |
Afiliação: |
ADALECIO KOVALESKI, CNPUV; MARCOS BOTTON, CNPUV; REGIS SIVORI SILVA DOS SANTOS, CNPUV; SILVIO ANDRE MEIRELLES ALVES, CNPUV. |
Título: |
Ameaças à viticultura e a fruticultura de clima temperado. |
Ano de publicação: |
2014 |
Fonte/Imprenta: |
Bento Gonçalves: Embrapa Uva e Vinho, 2014. |
Idioma: |
Português |
Notas: |
Produção gráfica: Luciana Mendonça Prado. |
Conteúdo: |
O folder aborda quatro das principais ameaças à viticultura e fruticultura de clima temperado. Apresenta uma breve descrição e histórico de cada praga bem como medidas de monitoramento e controle. As pragas abordadas são as seguintes: Cancro europeu (Neonectria ditissima) - em expansão, Drosofila da asa manchada (Drosophila suzukii) - recém detectada, Traça europeia dos cachos da videira (Lobesia botrana) - alerta, Cydia (Cydia pomonella) - erradicada. |
Palavras-Chave: |
Cancro europeu; Drosofila da asa manchada; Traça europeia dos cachos da videira; Videira. |
Thesagro: |
Controle integrado; Cydia pomonella; Drosofila; Fruticultura; Maçã; Morango; Pêra; Praga de planta; Uva; Viticultura. |
Thesaurus NAL: |
Drosophila suzukii; Lobesia botrana; Neonectria ditissima. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/140028/1/ameacas-a-viticultura-e-a-fruticultura.pdf
|
Marc: |
LEADER 01455nam a2200361 a 4500 001 1994912 005 2019-01-18 008 2014 bl uuuu u0uu1 u #d 100 1 $aKOVALESKI, A. 245 $aAmeaças à viticultura e a fruticultura de clima temperado. 260 $aBento Gonçalves: Embrapa Uva e Vinho$c2014 500 $aProdução gráfica: Luciana Mendonça Prado. 520 $aO folder aborda quatro das principais ameaças à viticultura e fruticultura de clima temperado. Apresenta uma breve descrição e histórico de cada praga bem como medidas de monitoramento e controle. As pragas abordadas são as seguintes: Cancro europeu (Neonectria ditissima) - em expansão, Drosofila da asa manchada (Drosophila suzukii) - recém detectada, Traça europeia dos cachos da videira (Lobesia botrana) - alerta, Cydia (Cydia pomonella) - erradicada. 650 $aDrosophila suzukii 650 $aLobesia botrana 650 $aNeonectria ditissima 650 $aControle integrado 650 $aCydia pomonella 650 $aDrosofila 650 $aFruticultura 650 $aMaçã 650 $aMorango 650 $aPêra 650 $aPraga de planta 650 $aUva 650 $aViticultura 653 $aCancro europeu 653 $aDrosofila da asa manchada 653 $aTraça europeia dos cachos da videira 653 $aVideira 700 1 $aBOTTON, M. 700 1 $aSANTOS, R. S. S. dos 700 1 $aALVES, S. A. M.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Uva e Vinho (CNPUV) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
Expressão de busca inválida. Verifique!!! |
|
|