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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agricultura Digital. Para informações adicionais entre em contato com cnptia.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Gado de Leite. |
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Data corrente: |
13/02/2017 |
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Data da última atualização: |
07/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ROSSE, I. C.; ASSIS, J. G.; OLIVEIRA, F. S.; LEITE, L. R.; ARAUJO, F.; ZERLOTINI NETO, A.; VOLPINI, A.; DOMINITINI, A. J.; LOPES, B. C.; ARBEX, W. A.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; MARTINS, M. F.; COIMBRA, R. S.; SILVA, M. V. G. B.; OLIVEIRA, G.; CARVALHO, M. R. S. |
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Afiliação: |
IZINARA C. ROSSE, UFMG; JULIANA G. ASSIS, UFMG; Fiocruz; FRANCISLON S. OLIVEIRA, UFMG; Fiocruz; LAURA R. LEITE, UFMG; Fiocruz; FLÁVIO ARAUJO, Fiocruz; ADHEMAR ZERLOTINI NETO, CNPTIA; ANGELA VOLPINI, Fiocruz; ANDERSON J. DOMINITINI, Fiocruz; BEATRIZ C. LOPES, Epamig; WAGNER ANTONIO ARBEX, CNPGL; MARCO ANTONIO MACHADO, CNPGL; MARIA GABRIELA CAMPOLINA D PEIXOTO, CNPGL; RUI DA SILVA VERNEQUE, CNPGL; MARTA FONSECA MARTINS, CNPGL; RONEY S. COIMBRA, Fiocruz; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; GUILHERME OLIVEIRA, Fiocruz; Vale Technology Institute, Belém; MARIA RAQUEL S. CARVALHO, UFMG. |
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Título: |
Whole genome sequencing of Guzera cattle reveals genetic variants in candidate genes for production, disease resistance, and heat tolerance. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Mammalian Genome, v. 28, n. 1-2, p. 66-80, 2017. |
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ISBN: |
10.1007/s00335-016-9670-7 |
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Idioma: |
Inglês |
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Notas: |
Na publicação: Adhemar Zerlotini, Rui S. Verneque. |
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Conteúdo: |
Abstract In bovines, artificial selection has produced a large number of breeds which differ in production, environmental adaptation, and health characteristics. To investigate the genetic basis of these phenotypical differences, several bovine breeds have been sequenced. Millions of new SNVs were described at every new breed sequenced, suggesting that every breed should be sequenced. Guzerat or Guzera´ is an indicine breed resistant to drought and parasites that has been the base for some important breeds such as Brahman. Here, we describe the sequence of the Guzera´ genome and the in silico functional analyses of intragenic breed-specific variations. Matepaired libraries were generated using the ABI SOLiD system. Sequences were mapped to the Bos taurus reference genome (UMD 3.1) and 87% of the reference genome was covered at a 26X. Among the variants identified, 2,676,067 SNVs and 463,158 INDELs were homozygous, not found in any database searched, and may represent true differences between Guzera´ and B. taurus. Functional nalyses investigated with the NGS-SNP package focused on 1069 new, non-synonymous SNVs, splice-site variants (including acceptor and donor sites, and the conserved regions at both intron borders, referred to here as splice regions) and coding INDELs (NS/SS/I). These NS/SS/I map to 935 genes belonging to cell communication, environmental adaptation, signal transduction, sensory, and immune systems pathways. These pathways have been involved in phenotypes related to health, adaptation to the environment and behavior, and particularly, disease resistance and heat tolerance. Indeed, 105 of these genes are known QTLs for milk, meat and carcass, production, reproduction, and health traits. Therefore, in addition to describing new genetic variants, our approach provided groundwork for unraveling key candidate genes and mutations. MenosAbstract In bovines, artificial selection has produced a large number of breeds which differ in production, environmental adaptation, and health characteristics. To investigate the genetic basis of these phenotypical differences, several bovine breeds have been sequenced. Millions of new SNVs were described at every new breed sequenced, suggesting that every breed should be sequenced. Guzerat or Guzera´ is an indicine breed resistant to drought and parasites that has been the base for some important breeds such as Brahman. Here, we describe the sequence of the Guzera´ genome and the in silico functional analyses of intragenic breed-specific variations. Matepaired libraries were generated using the ABI SOLiD system. Sequences were mapped to the Bos taurus reference genome (UMD 3.1) and 87% of the reference genome was covered at a 26X. Among the variants identified, 2,676,067 SNVs and 463,158 INDELs were homozygous, not found in any database searched, and may represent true differences between Guzera´ and B. taurus. Functional nalyses investigated with the NGS-SNP package focused on 1069 new, non-synonymous SNVs, splice-site variants (including acceptor and donor sites, and the conserved regions at both intron borders, referred to here as splice regions) and coding INDELs (NS/SS/I). These NS/SS/I map to 935 genes belonging to cell communication, environmental adaptation, signal transduction, sensory, and immune systems pathways. These pathways have been involved in phenotypes ... Mostrar Tudo |
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Palavras-Chave: |
Diseases; Genome sequencing; Sequência genética. |
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Thesagro: |
Bos Indicus; Gado de corte. |
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Thesaurus Nal: |
breeding; dairy cattle; Genome; Zebu. |
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Categoria do assunto: |
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L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 03169naa a2200445 a 4500
001 2072807
005 2020-01-07
008 2017 bl uuuu u00u1 u #d
100 1 $aROSSE, I. C.
245 $aWhole genome sequencing of Guzera cattle reveals genetic variants in candidate genes for production, disease resistance, and heat tolerance.$h[electronic resource]
260 $c2017
500 $aNa publicação: Adhemar Zerlotini, Rui S. Verneque.
520 $aAbstract In bovines, artificial selection has produced a large number of breeds which differ in production, environmental adaptation, and health characteristics. To investigate the genetic basis of these phenotypical differences, several bovine breeds have been sequenced. Millions of new SNVs were described at every new breed sequenced, suggesting that every breed should be sequenced. Guzerat or Guzera´ is an indicine breed resistant to drought and parasites that has been the base for some important breeds such as Brahman. Here, we describe the sequence of the Guzera´ genome and the in silico functional analyses of intragenic breed-specific variations. Matepaired libraries were generated using the ABI SOLiD system. Sequences were mapped to the Bos taurus reference genome (UMD 3.1) and 87% of the reference genome was covered at a 26X. Among the variants identified, 2,676,067 SNVs and 463,158 INDELs were homozygous, not found in any database searched, and may represent true differences between Guzera´ and B. taurus. Functional nalyses investigated with the NGS-SNP package focused on 1069 new, non-synonymous SNVs, splice-site variants (including acceptor and donor sites, and the conserved regions at both intron borders, referred to here as splice regions) and coding INDELs (NS/SS/I). These NS/SS/I map to 935 genes belonging to cell communication, environmental adaptation, signal transduction, sensory, and immune systems pathways. These pathways have been involved in phenotypes related to health, adaptation to the environment and behavior, and particularly, disease resistance and heat tolerance. Indeed, 105 of these genes are known QTLs for milk, meat and carcass, production, reproduction, and health traits. Therefore, in addition to describing new genetic variants, our approach provided groundwork for unraveling key candidate genes and mutations.
650 $abreeding
650 $adairy cattle
650 $aGenome
650 $aZebu
650 $aBos Indicus
650 $aGado de corte
653 $aDiseases
653 $aGenome sequencing
653 $aSequência genética
700 1 $aASSIS, J. G.
700 1 $aOLIVEIRA, F. S.
700 1 $aLEITE, L. R.
700 1 $aARAUJO, F.
700 1 $aZERLOTINI NETO, A.
700 1 $aVOLPINI, A.
700 1 $aDOMINITINI, A. J.
700 1 $aLOPES, B. C.
700 1 $aARBEX, W. A.
700 1 $aMACHADO, M. A.
700 1 $aPEIXOTO, M. G. C. D.
700 1 $aVERNEQUE, R. da S.
700 1 $aMARTINS, M. F.
700 1 $aCOIMBRA, R. S.
700 1 $aSILVA, M. V. G. B.
700 1 $aOLIVEIRA, G.
700 1 $aCARVALHO, M. R. S.
773 $tMammalian Genome$gv. 28, n. 1-2, p. 66-80, 2017.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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Biblioteca |
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Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
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URL |
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| Registros recuperados : 91 | |
| 81. |  | PANETTO, J. C. do C.; PEIXOTO, M. G. C. D.; SANTOS, G. G. dos; BRUNELI, F. A. T.; VERNEQUE, R. da S.; MACHADO, M. A.; AZEVEDO, A. L. S.; REIS, D. R. L.; SILVA, L. A.; EGITO, A. A. do; CARVALHO, M. R. S. Population structure and identification of lineages in a Brazilian Guzerat metapopulation. In: ASAS JOINT ANNUAL MEETING. Journal of Dairy Science v. 96, Suppl. 1, p. 142, 2013.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Corte. |
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| 82. | | FONSECA, P. A. S.; LEAL, T. P.; SANTOS, F. C.; GOUVEIA, M. H.; ID-LAHOUCINE, S.; ROSSE, I. C.; VENTURA, R. V.; BRUNELI, F. A. T.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; TARAZONA-SANTOS, E.; CARVALHO, M. R. S. Reducing cryptic relatedness in genomic data sets via a central node exclusion algorithm. Molecular Ecology Resources, v. 18, n. 3, 2018.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 83. | | ROSSE, I. C.; ASSIS, J. G.; OLIVEIRA, F. S.; LEITE, L. R.; ARAUJO, F.; ZERLOTINI, A.; LOPES, B. C.; ARBEX, W. A.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; VERNEQUE, R. S.; GUIMARÃES, M. F. M.; SILVA, M. V. G. B.; COIMBRA, R. S.; OLIVEIRA, G.; CARVALHO, M. R. S. Novel polymorphisms in genes associated with milk and meat production and disease resistance in the Guzerá breed identified by whole-genome sequencing. In: ENCONTRO DE GENÉTICA DE MINAS GERAIS: PESQUISA E PÓS GRADUAÇÃO, 5., 2014, Belo Horizonte. Anais... Belo Horizonte: Sociedade Brasileira de Genética, 2014. p. 74. Engemig 2014.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 84. | | ROSSE, I. C.; OLIVEIRA, F. S.; LEITE, L. R.; ARAUJO, F.; ZERLOTINI NETO, A.; LOPES, B. C.; ARBEX, W. A.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; GUIMARAES, M. F. M.; SILVA, M. V. G. B.; COIMBRA, R. S.; OLIVEIRA, G.; CARVALHO, M. R. S. Novel polymorphisms in genes associated with milk and meat production and disease resistance in the guzera breed identified by whole-genome sequencing. In: ENCONTRO DE GENÉTICA DE MINAS GERAIS: PESQUISA E PÓS GRADUAÇÃO, 5., 2014, Belo Horizonte. Anais... Belo Horizonte: Sociedade Brasileira de Genética, 2014.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 85. | | CRUZ, I. R.; GERALDO, L. A.; OLIVEIRA, F. S. DE; LEITE, L. R.; ARAUJO, F.; ZERLOTINI NETO, A.; LOPES, B. C.; ARBEX, W. A.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; MARTINS, M. F.; SILVA, M. V. G. B.; COIMBRA, R. S.; CARVALHO, M. R. S.; OLIVEIRA, G. New single nucleotide polymorphisms in guzerá breed revealed by whole-genome re-sequencing. In: INTERNATIONAL CONFERENCE OF THE AB3C; BRAZILIAN SYMPOSIUM ON BIOINFORMATICS, 2013, Recife. Abstract book... Recife: Brazilian Association for Bioinformatics and Computer Biology; Braziian Computer Society, 2013.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 86. | | CRUZ, I. R.; GERALDO, J. A.; OLIVEIRA, F. S. de; LEITE, L. R.; ARAÚJO, F.; ZERLOTINI, A.; LOPES, B. C.; ARBEX, W. A.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; MARTINS, M. F.; SILVA, M. V. G. B.; COIMBAR, R. S.; CARVALHO, M. R. S.; OLIVEIRA, G. New single sucleotide polymorphisms in Guzerá breed revealed by whole-genome re-sequencing. In: INTERNATIONAL CONFERENCE OF THE AB3C; BRAZILIAN SYMPOSIUM ON BIOINFORMATICS, 2013, Recife. Abstract book... Recife: Brazilian Association for Bioinformatics and Computer Biology; Braziian Computer Society, 2013. Não paginado. X-meeting BSB 2013. Abstract 76.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 87. | | CRUZ, I. R.; GERALDO, J. A.; OLIVEIRA, F. S.; LEITE, L. R.; ARAÚJO, F.; ZERLOTINI NETO, A.; LOPES, B. C.; ARBEX, W. A.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; MARTINS, M. F.; SILVA, M. V. G. B.; COIMBRA, R. S.; CARVALHO, M. R. S.; OLIVEIRA, G. Whole-genome sequecing of guzera breed revealed SNPs with potential implication for milk production. In: INTERNATIONAL PLANT & ANIMAL GENOME, 22., 2014, San Diego, CA. Abstracts... San Diego: [s.n], 2014.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 88. | | CRUZ, I. R.; GERALDO, J. A.; OLIVEIRA, F. S.; LEITE, L. R.; ARAÚJO, F.; ZERLOTINI, A.; LOPES, B. C.; ARBEX, W. A.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; VERNEQUE, R. S.; GUIMARÃES, M. F. M.; SILVA, M. V. G. B.; COIMBRA, R. S.; CARVALHO, M. R. S.; OLIVEIRA, G. Whole genome sequencing of Guzerá breed revealed SNPS with potentialimplication for milk production. In: PLANT & ANIMAL GENOME CONFERENCE, 22., 2014, San Diego, CA. [Abstracts...]. San Diego: [s.n.], 2014. Não paginado. Pôster P561.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 89. | | ROSSE, I. C.; ASSIS, J. G.; OLIVEIRA, F. S.; LEITE, L. R.; ARAUJO, F.; ZERLOTINI NETO, A.; VOLPINI, A.; DOMINITINI, A. J.; LOPES, B. C.; ARBEX, W. A.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; MARTINS, M. F.; COIMBRA, R. S.; SILVA, M. V. G. B.; OLIVEIRA, G.; CARVALHO, M. R. S. Whole genome sequencing of Guzera cattle reveals genetic variants in candidate genes for production, disease resistance, and heat tolerance. Mammalian Genome, v. 28, n. 1-2, p. 66-80, 2017. Na publicação: Adhemar Zerlotini, Rui S. Verneque.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Gado de Leite. |
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| 90. | | FONSECA, P. A. de S.; SANTOS, F. C. dos; ROSSE, I. C.; VENTURA, R. V.; BRUNELI, F. A. T.; PENNA, V. M.; VERNEQUE, R. da S.; MACHADO, M. A.; SILVA, M. V. G. B.; CARVALHO, M. R. S.; PEIXOTO, M. G. C. D. Retelling the recent evolution of genetic diversity for Guzerá: Inferences from LD decay, runs of homozygosity and Ne over the generations. Livestock Science, v. 193, p. 110-117, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 91. | | ARAUJO, F.; DRUMOND, B.; ZERLOTINI, A.; ROSE, I. C.; LOPES, B. C.; GUEDES, E.; ARBEX, W. A.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; GUIMARAES, M. F. M.; COIMBRA, R. S.; CARVALHO, M. R. S.; SILVA, M. V. G. B.; OLIVEIRA, G. C. Zebu genome sequencing and analysis using second generation sequencers. In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 6., 2010, Ouro Preto. Abstracts... [S.l.: s.n.], 2010.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 91 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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