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Registro Completo |
Biblioteca(s): |
Embrapa Agroenergia. |
Data corrente: |
06/09/2022 |
Data da última atualização: |
06/09/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
SANNOMIYA, M.; RODRIGUES, C. M.; OLIVEIRA, G. C. A.; CARVALHO, J. C. S.; COSTA, L. S. DA; SPADARI, C. DE C.; FERREIRA, M. J. P.; VILEGAS, W.; ISHIDA, K. |
Afiliação: |
MIRIAM SANNOMIYA, UNIVERSITY OF SÃO PAULO; CLENILSON MARTINS RODRIGUES, CNPAE; GIOVANNA CASTRO ARAÚJO OLIVEIRA, UNIVERSITY OF SÃO PAULO; JULIANA CAJADO SOUZA CARVALHO, UNIVERSITY OF SÃO PAULO; LETÍCIA SERAFIM DA COSTA, UNIVERSITY OF SÃO PAULO; CRISTINA DE CASTRO SPADARI, UNIVERSITY OF SÃO PAULO; MARCELO JOSÉ PENA FERREIRA, UNIVERSITY OF SÃO PAULO; WAGNER VILEGAS, SÃO PAULO STATE UNIVERSITY; KELLY ISHIDA, UNIVERSITY OF SÃO PAULO. |
Título: |
Galloylquinic acid derivatives from Byrsonima fagifolia leaf extract and potential antifungal activity. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Journal of Ethnopharmacology, n. 297, e115534, 2022. |
Páginas: |
5 p. |
DOI: |
https://doi.org/10.1016/j.jep.2022.115534 |
Idioma: |
Inglês |
Conteúdo: |
Ethnopharmacological relevance: Byrsonima fagifolia Niedenzu (Malpighiaceae) and other Byrsonima species are popularly employed in Brazilian traditional medicine in the form of preparations as cicatrizing, antiinflammatory, and antimicrobial. Aim of the study: To characterize the phytochemical profile of the hydromethanolic extract obtained from B. fagifolia leaves (BF extract) and to evaluate the toxicity and the antifungal activity. based on extensive analyses of 1D and 2D NMR spectra (HMQC, HMBC and COSY) data. The antifungal effect was determined by the broth microdilution method and the toxicity was evaluated on erythrocytes from sheep?s blood and Galleria mellonella larvae. Results: Phytochemical investigation of the BF extract led to the isolation and characterization of pyrogallol, nbutyl gallate, 3,4-di-O-galloylquinic acid, 3,5-di-O-galloylquinic acid, 3,4,5-tri-O-galloylquinic acid, and 1,3,4,5-tetra-O-galloylquinic acid. The BF extract showed high content of galloylquinic acid derivatives reaching more than twenty-times the quercetin derivatives content, according to the quantification by HPLC. These galloylquinic acid derivatives, obtained during this study, and quercetin derivatives, previously isolated, were submitted to the antifungal assays. The BF extract inhibited yeast growth mainly against Cryptococcus spp., at concentrations of 1?16 ?g/mL, comparable to isolated compounds galloylquinic acid derivatives. However, the quercetin derivatives as well as quinic acid, gallic acid, and methyl gallate showed lower antifungal effect compared with galloylquinic derivatives. In addition, the BF extract had no hemolytic effect and no toxicity on G. mellonella. MenosEthnopharmacological relevance: Byrsonima fagifolia Niedenzu (Malpighiaceae) and other Byrsonima species are popularly employed in Brazilian traditional medicine in the form of preparations as cicatrizing, antiinflammatory, and antimicrobial. Aim of the study: To characterize the phytochemical profile of the hydromethanolic extract obtained from B. fagifolia leaves (BF extract) and to evaluate the toxicity and the antifungal activity. based on extensive analyses of 1D and 2D NMR spectra (HMQC, HMBC and COSY) data. The antifungal effect was determined by the broth microdilution method and the toxicity was evaluated on erythrocytes from sheep?s blood and Galleria mellonella larvae. Results: Phytochemical investigation of the BF extract led to the isolation and characterization of pyrogallol, nbutyl gallate, 3,4-di-O-galloylquinic acid, 3,5-di-O-galloylquinic acid, 3,4,5-tri-O-galloylquinic acid, and 1,3,4,5-tetra-O-galloylquinic acid. The BF extract showed high content of galloylquinic acid derivatives reaching more than twenty-times the quercetin derivatives content, according to the quantification by HPLC. These galloylquinic acid derivatives, obtained during this study, and quercetin derivatives, previously isolated, were submitted to the antifungal assays. The BF extract inhibited yeast growth mainly against Cryptococcus spp., at concentrations of 1?16 ?g/mL, comparable to isolated compounds galloylquinic acid derivatives. However, the quercetin derivatives as well as quin... Mostrar Tudo |
Thesagro: |
Fitotoxicidade; Planta Medicinal. |
Thesaurus Nal: |
Antifungal agents; Chemical constituents of plants; Malpighiaceae; Muricidae. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1146197/1/Galloylquinic-acid-derivatives.pdf
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Marc: |
LEADER 02644naa a2200313 a 4500 001 2146197 005 2022-09-06 008 2022 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.jep.2022.115534$2DOI 100 1 $aSANNOMIYA, M. 245 $aGalloylquinic acid derivatives from Byrsonima fagifolia leaf extract and potential antifungal activity.$h[electronic resource] 260 $c2022 300 $a5 p. 520 $aEthnopharmacological relevance: Byrsonima fagifolia Niedenzu (Malpighiaceae) and other Byrsonima species are popularly employed in Brazilian traditional medicine in the form of preparations as cicatrizing, antiinflammatory, and antimicrobial. Aim of the study: To characterize the phytochemical profile of the hydromethanolic extract obtained from B. fagifolia leaves (BF extract) and to evaluate the toxicity and the antifungal activity. based on extensive analyses of 1D and 2D NMR spectra (HMQC, HMBC and COSY) data. The antifungal effect was determined by the broth microdilution method and the toxicity was evaluated on erythrocytes from sheep?s blood and Galleria mellonella larvae. Results: Phytochemical investigation of the BF extract led to the isolation and characterization of pyrogallol, nbutyl gallate, 3,4-di-O-galloylquinic acid, 3,5-di-O-galloylquinic acid, 3,4,5-tri-O-galloylquinic acid, and 1,3,4,5-tetra-O-galloylquinic acid. The BF extract showed high content of galloylquinic acid derivatives reaching more than twenty-times the quercetin derivatives content, according to the quantification by HPLC. These galloylquinic acid derivatives, obtained during this study, and quercetin derivatives, previously isolated, were submitted to the antifungal assays. The BF extract inhibited yeast growth mainly against Cryptococcus spp., at concentrations of 1?16 ?g/mL, comparable to isolated compounds galloylquinic acid derivatives. However, the quercetin derivatives as well as quinic acid, gallic acid, and methyl gallate showed lower antifungal effect compared with galloylquinic derivatives. In addition, the BF extract had no hemolytic effect and no toxicity on G. mellonella. 650 $aAntifungal agents 650 $aChemical constituents of plants 650 $aMalpighiaceae 650 $aMuricidae 650 $aFitotoxicidade 650 $aPlanta Medicinal 700 1 $aRODRIGUES, C. M. 700 1 $aOLIVEIRA, G. C. A. 700 1 $aCARVALHO, J. C. S. 700 1 $aCOSTA, L. S. DA 700 1 $aSPADARI, C. DE C. 700 1 $aFERREIRA, M. J. P. 700 1 $aVILEGAS, W. 700 1 $aISHIDA, K. 773 $tJournal of Ethnopharmacology$gn. 297, e115534, 2022.
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Registro original: |
Embrapa Agroenergia (CNPAE) |
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Registros recuperados : 54 | |
7. | | ROSA, I. V.; CARVALHO, J. C.; HOUSER, R. H.; DOBEREINER, J. Influência de ração balanceada sobre a ?cara inchada? (doença peridentária) de bezerros. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 11, n. 9, p. 59-63, 1976. (Veterinária). Título em inglês: Effect of barn feeding on "Cara inchada" (periodontal disease) in calves.Biblioteca(s): Embrapa Unidades Centrais. |
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9. | | CARVALHO, J. C. B. de; GREGO, C. R.; VIERIA, S. R.; ESPINDOLA, C. R. Variabilidade espacial de atributos físicos do solo em áreas de empréstimo para construção da hidrelétrica de Ilha Solteira (SP). In: CONGRESO INTERNACIONAL DE INGENIERÍA AGRÍCOLA, 1., 2010, Chillán, Chile. Anales... Chillán, Chile: Universidad de Concepción, 2010. 13 p.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Territorial. |
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10. | | BERGIER, I.; ASSINE, M. L.; MCGLUE, M. M.; ALHO, C. J. R.; SILVA, A.; GUERREIRO, R. L.; CARVALHO, J. C. Amazon rainforest modulation of water security in the Pantanal wetland. Science of the Total Environment, v. 619 - 620, p. 1116-1125, apr. 2018.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
Biblioteca(s): Embrapa Pantanal. |
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12. | | FISS, A. V.; CARVALHO, J. C; KUNDE, R. J.; SANTOS, D. C.; SILVA, J. L. S. da; PILLON, C. N. Estoque de carbono sobre sistema de integração lavoura-pecuária. In: ENCONTRO DE INICIAÇÃO CIENTÍFICA E PÓS-GRADUAÇÃO DA EMBRAPA CLIMA TEMPERADO, 4., 2012, Pelotas. Ciência e inovação para 2050: qual o futuro que queremos? Resumos e palestras... Pelotas: Embrapa Clima Temperado, 2012. 1 CD-ROM.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Clima Temperado. |
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13. | | CARVALHO, J. C. M.; MAGNABOSCO, C. de U.; CORDEIRO, C. T.; LOS REYES, A.; LOBO, R. B. Estrutura familiar de um rebanho da raca Nelore: germoplasma puro de origem importada. In: REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 31., 1994, Maringa, PR. Anais... Maringa: Sociedade Brasileira de Zootecnia, 1994. p.147. ResumoBiblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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14. | | SILVA, D. G. da; ANTUNES, L. F. de S.; SCORIZA, R. N.; CARVALHO, J. C.; CORREIA, M. E. F. Crescimento de mudas de hortaliças em substratos orgânicos. Growth of vegetable seedlings on organic substrates. Cadernos de Agroecologia, v. 13, n. 1, p. 1-7, Jul. 2018. ANAIS CONGRESSO LATINO-AMERICANO DE AGROECOLOGIA, 6.; CONGRESSO BRASILEIRO DE AGROECOLOGIA, 10.; SEMINÁRIO DE AGROECOLOGIA DO DISTRITO FEDERAL E ENTORNO, 5., 2017, Brasília, DF. Agroecologia na transformação dos sistemas agroalimentares...Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Agrobiologia. |
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15. | | CARVALHO, J. C. C.; BERTECHINI, A. G.; LIMA, G. J. M. M. de; SILVA, C. L. S.; FIGUEIREDO, G. O. Utilização de protetores enzimáticos em dietas para frangos de corte, desempenho. In: CONFERÊNCIA APINCO DE CIÊNCIA E TECNOLOGIA AVÍCOLAS, 2007, Santos, SP. Anais... Campinas: FACTA, 2007. Trabalhos de pesquisa. p. 127. Projeto n. 10.06.11.025-01.Tipo: Artigo em Anais de Congresso / Nota Técnica | Circulação/Nível: -- - -- |
Biblioteca(s): Embrapa Suínos e Aves. |
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16. | | SANTOS, A. M. dos; CARVALHO, J. C. R. de; NASCIMENTO, C. A. C. do; BORGES, A. L. Utilização da terra de quixabeira como fertilizante natural. In: SEMINÁRIO DE PESQUISA DO RECÔNCAVO DA BAHIA, 3.; SEMINÁRIO ESTUDANTIL DE PESQUISA DA UFRB, 3.; SEMINÁRIO DE PÓS-GRADUAÇÃO DA UFRB, 3., 2009, Cruz das Almas. Evolução do conhecimento e o desenvolvimento social: [resumos...]. Cruz das Almas: Universidade Federal do Recôncavo da Bahia, 2009. 01 CD-ROM.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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18. | | REISSER JUNIOR, C.; CARVALHO, J. C.; CASTAÑEDA, L. M. F.; RISOW, N. C.; CARPENEDO, S.; ANTUNES, L. E. C. Water potential change in the beds of strawberry cultivated under different types of mulching. In: INTERNATIONAL STRAWBERRY SYMPOSIUM, 6., 2009, Huelva. Book of abstracts ... Huelva: ISHS, 2009. p. 167-170.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Clima Temperado. |
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19. | | CORREIA, A. F.; SEGOVIA, J. F. O.; GONÇALVES, M. C. A.; OLIVEIRA, V. L. de; SILVEIRA, D.; CARVALHO, J. C. T.; KANZAKI, L. I. B. Amazonian plant crude extract screening for activity against multidrug-resistant bacteria. European Review for Medical and Pharmacological Sciences, Itália, v. 12, n. 6, p. 369-380, 2008. Disponivel também on line.Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 4 |
Biblioteca(s): Embrapa Amapá. |
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20. | | DIAS, J. do S. A.; LIRA-GUEDES, A. C.; FERREIRA, I. M.; OLIVEIRA, A. E. M. de F. M.; CARVALHO, J. C. T. de. Avaliação in vitro da atividade antifúngica do óleo resina da copaibeira (Copaifera reticulata Ducke) e da sua nanoemulsão sobre uma cepa selvagem de Aspergillus fumigatus Fresenius isolada da castanheira-do-Brasil (Bertholletia excelsa Bompl.). Research, Society and Development, v. 12, n. 4, e9512440852, 2023.Tipo: Artigo em Periódico Indexado | Circulação/Nível: C - 0 |
Biblioteca(s): Embrapa Amapá. |
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Registros recuperados : 54 | |
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