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Registro Completo |
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Biblioteca(s): |
Embrapa Meio Norte / UEP-Parnaíba. |
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Data corrente: |
19/08/1996 |
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Data da última atualização: |
19/08/1996 |
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Autoria: |
RIBEIRO-DASILVA, C.R.; CARLINI, C. R.; PIRES-BARBOSA, R.; GUIMARAES, J. A. |
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Título: |
Blood glucose alterations induced in rats by canatoxin, a protein isolated from jack bean (Canavalia ensiformis) seeds. |
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Ano de publicação: |
1986 |
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Fonte/Imprenta: |
Toxicon, v.24, n.8, p.775-782, 1986. |
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Idioma: |
Inglês |
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Conteúdo: |
Canatoxin, a lethal convulsant protein isolated from the seeds of Canatoxin ensiformis (Jack bean), induced a biphasis alterations in blood glucose levels when injected j.v. into rats and mice. After administration of subconvulsant doses of canatoxin the rats showed initially hyperglycemia during the first 30 min. Followed by a long-lasting hypoglycemia. Return to basal glucose levels was not seen up to 15 days. The hyperglycemic effect was dose-dependent and occurred in starved and well-fed animals. A parallelism between convulsant and hyperglycemic was observed throughout all canatoxin purification steps. Mice were about 20-fold less sensitive (on a weight basis) than rats to canatoxin-induced hyperglycemia. The hyperglycemia phase was not as affected by pretreatment on the rats with alpha or beta-adrenergic blockers or chlorpromazine, but was potentially by reserpine and haloperidol. Diazepan and hexamethonium were able to block the hyperglymic phase of canatoxin's effect. The results suggest that the hyperglycemic alterations induced by canatoxin in rats and mice are probably mediated via the central nervous system. |
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Palavras-Chave: |
Bean; Isolated protein; Proteina isolada. |
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Thesagro: |
Canavalia Ensiformis; Feijão; Phaseolus Vulgaris. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01807naa a2200229 a 4500
001 1078028
005 1996-08-19
008 1986 bl --- 0-- u #d
100 1 $aRIBEIRO-DASILVA, C.R.
245 $aBlood glucose alterations induced in rats by canatoxin, a protein isolated from jack bean (Canavalia ensiformis) seeds.
260 $c1986
520 $aCanatoxin, a lethal convulsant protein isolated from the seeds of Canatoxin ensiformis (Jack bean), induced a biphasis alterations in blood glucose levels when injected j.v. into rats and mice. After administration of subconvulsant doses of canatoxin the rats showed initially hyperglycemia during the first 30 min. Followed by a long-lasting hypoglycemia. Return to basal glucose levels was not seen up to 15 days. The hyperglycemic effect was dose-dependent and occurred in starved and well-fed animals. A parallelism between convulsant and hyperglycemic was observed throughout all canatoxin purification steps. Mice were about 20-fold less sensitive (on a weight basis) than rats to canatoxin-induced hyperglycemia. The hyperglycemia phase was not as affected by pretreatment on the rats with alpha or beta-adrenergic blockers or chlorpromazine, but was potentially by reserpine and haloperidol. Diazepan and hexamethonium were able to block the hyperglymic phase of canatoxin's effect. The results suggest that the hyperglycemic alterations induced by canatoxin in rats and mice are probably mediated via the central nervous system.
650 $aCanavalia Ensiformis
650 $aFeijão
650 $aPhaseolus Vulgaris
653 $aBean
653 $aIsolated protein
653 $aProteina isolada
700 1 $aCARLINI, C. R.
700 1 $aPIRES-BARBOSA, R.
700 1 $aGUIMARAES, J. A.
773 $tToxicon$gv.24, n.8, p.775-782, 1986.
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Registro original: |
Embrapa Meio Norte / UEP-Parnaíba (CPAMN-UEPP) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Arroz e Feijão. Para informações adicionais entre em contato com cnpaf.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Arroz e Feijão. |
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Data corrente: |
04/11/1994 |
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Data da última atualização: |
04/11/1994 |
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Autoria: |
KLUTHCOUSKI, J.; BOUZINAC, S.; SEGUY, L. |
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Título: |
Preparo do solo. |
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Ano de publicação: |
1988 |
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Fonte/Imprenta: |
In: ZIMMERMANN, M. J. de O.; ROCHA, M.; YAMADA, Y. (Ed.). Cultura do feijoeiro: fatores que afetam a produtividade. Piracicaba: Associacao Brasileira para Pesquisa da Potassa e do Fosfato, 1988. |
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Páginas: |
p. 249-259. |
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Idioma: |
Português |
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Palavras-Chave: |
Preparo; Solos. |
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Thesagro: |
Feijão; Phaseolus Vulgaris. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 00607naa a2200193 a 4500
001 1198042
005 1994-11-04
008 1988 bl uuuu u00u1 u #d
100 1 $aKLUTHCOUSKI, J.
245 $aPreparo do solo.
260 $c1988
300 $ap. 249-259.
650 $aFeijão
650 $aPhaseolus Vulgaris
653 $aPreparo
653 $aSolos
700 1 $aBOUZINAC, S.
700 1 $aSEGUY, L.
773 $tIn: ZIMMERMANN, M. J. de O.; ROCHA, M.; YAMADA, Y. (Ed.). Cultura do feijoeiro: fatores que afetam a produtividade. Piracicaba: Associacao Brasileira para Pesquisa da Potassa e do Fosfato, 1988.
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Registro original: |
Embrapa Arroz e Feijão (CNPAF) |
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