Data/hora: 18/06/2024 18:09:18

Biblioteca(s): 	Embrapa Caprinos e Ovinos.	
Data corrente: 	01/08/1992	
Data da última atualização: 	05/01/2024	
Autoria: 	HAQUE, A.; OUAISSI, A.; JOSEPH, M.; CAPRIN, M.; CAPRON, A.	
Título: 	IgE antibody in eosinophil- and macrophage-mediated in vitro killing of dipetalonema viteae microfilariae.	
Ano de publicação: 	1981	
Fonte/Imprenta: 	Journal of Immunology, v. 127, n. 2, p. 716-725, 1981.	
Idioma: 	Inglês	
Conteúdo: 	Abstract : Microfilariae of Dipetalonema viteae[Acanthocheilonema viteae] were incubated at 37°C for 24 h with peritoneal eosinophils and macrophages and with serum of rats immunized to D. viteae adults and microfilariae. In these circumstances the cells adhered to the microfilariae and destroyed them. This reaction depended upon a factor in the immune serum which was non-opsonic; it was heat labile but it was not complement. Immunoadsorption and inhibition experiments showed that it was an IgE antibody. Electron-microscope studies showed that eosinophils adhered to the microfilariae early and discharged their granules onto them; this did not kill them but it immobilized them. Later macrophages adhered; after 16 h lysosome granules appeared in the cells, and the microfilariae were destroyed. The factor in serum was species specific and there was no cross-reaction with Trichinella spiralis.	
Palavras-Chave: 	Cricetinae Cytotoxicity; Helminthoses; Nematodeo; Time Factors.	
Thesagro: 	Imunologia; Mamífero; Parasitologia.	
Thesaurus Nal: 	Animal parasitic nematodes; Antibodies; Cell adhesion; Cell movement; Helminths; Immunoglobulin E; Immunology; Macrophages; Microfilariae; Nematode infections; Rats; Trichinella.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Caprinos e Ovinos (CNPC)	
Exemplares: 	CNPC - (6250-1) - ADD - AP - PP - SP 04066 -  - SP 04066 - DIS